Wyniki wyszukiwania

1

Spectrophotometric methods as a novel screening approach for analysis of dihydropirimidine dehydrogenase activity before treatment with 5-fluorouracil chemotherapy

100%

Dolegowska B., Ostapowicz A., Stanczyk-Dunaj M., Blogowski W.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 4

2

Effect of hypoxia on toxicity induced by anticancer agents in cardiomyocyte culture

100%

Mandziuk S., Kus P., Dudka J., Madej-Czerwonka B., Cendrowska-Pinkosz M., Iwan M., Luszczewska-Sierakowska I., Korga A.

Medycyna Weterynaryjna

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2014

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tom 70

|

nr 05

The main goal of the study was to determine whether hypoxia augments the toxicity of anticancer drugs towards cardiomyocytes. Drugs selected for this experiment were those that disturb the cardiac redox equilibrium. Cardiomyocytes were incubated for 24 h with doxorubicin, tirapazamine, and 5-fluorouracil, each at three doses, under normoxia and under 50% and 90% hypoxia. The cytotoxic effect was evaluated on the basis of the percentage of living cells, cell vitality (assessed by the MTT assay), and morphology. In addition, the oxidative marker and pH value were determined. Varied protective effects of hypoxia on cell morphology were observed in all cases except the medium concentration of tirapazamine. The 50% hypoxia prevented the toxic effects of all tested drugs. The 90% hypoxia, on the other hand, was effective against the cytotoxic action of doxorubicin and 5-fluoruracil, but the cytotoxicity of tirapazamine increased. It was found that under the 90% hypoxia the oxidative stress observed under normoxia and the 50% hypoxia was greatly reduced. The study revealed that the above drugs did not activate anaerobic glycolysis.

3

Pitfalls in the diagnosis of patients with a dihydropyrimidine dehydrogenase deficiency in blood cells

100%

Van Kuilenburg A. B. P., Van Lenthe H., Van Gennip A. H.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

4

Decreased in vivo toxicity and enhanced cytotoxicity of FdUMP

100%

Gmeiner W. H., Liu J., Talmadge J.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

5

Assessment of neurotoxicity of pharmacological compounds during early neural development of human embryonic stem cells

84%

Kang H. Y., Hong E. J., Kang H. S., Ahn C., Jeung E. B.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 2

6

In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers

84%

Kryczka T., Bero M., Kasperczyk J., Dobrzynski P., Marciniec B., Popielarz-Brzezinska M., Grieb P.

Acta Biochimica Polonica

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2002

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tom 49

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nr 1

The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37°C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire observation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indicated.

7

A competitive template RT-PCR to measure mRNA encoding for folate metabolizing enzymes, such as thimidylate synthase, in leukemia and colon cancer

84%

Peters G. J., Rots M. G., Noordhuis P., Mauritz R., Willey J. C., Demuth J. P., Van Zantwijk C. H., Pieters R., Jansen G.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

8

Inhibition of Leishmania growth but not of phagocytic functions of macrophages by 5-fluorouracil in vitro

84%

Becker I., Perez-Montfort R., Perez-Torres A., Vazquez-Arana S., Carrillo-Farga L., Salaiza N., Cruz B., Marquez-Monter H., Perez-Tamayo R.

Acta Protozoologica

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1995

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tom 34

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nr 4

9

Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons

67%

Sano T., Utsumi D., Amagase K., Matsumoto K., Tominaga M., Higuchi K., Takeuchi T., Kato S.

Journal of Physiology and Pharmacology

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2017

|

tom 68

|

nr 1

10

The use of morphometric and fractal parameters to assess the effects of 5-fluorouracil, interferon and dexamethasone treatment on colonic anastomosis healing: an experimental study in rats

67%

Letowska-Andrzejewicz K., Torres A., Torres K., Dobrowolski P., Piersiak T., Maciejewski R., Gawron A., Staskiewicz G., Plewa Z.

Folia Histochemica et Cytobiologica

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2011

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tom 49

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nr 1

11

Identification of teratogens in cell culture. II. Laboratory values of rat embryo midbrain studied by micromass test with penicillin G and 5-fluorouracil

67%

Minta M.

Bulletin of the Veterinary Institute in Puławy

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2003

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tom 47

|

nr 2

Ograniczanie wyników

Spectrophotometric methods as a novel screening approach for analysis of dihydropirimidine dehydrogenase activity before treatment with 5-fluorouracil chemotherapy

Effect of hypoxia on toxicity induced by anticancer agents in cardiomyocyte culture

Pitfalls in the diagnosis of patients with a dihydropyrimidine dehydrogenase deficiency in blood cells

Decreased in vivo toxicity and enhanced cytotoxicity of FdUMP

Assessment of neurotoxicity of pharmacological compounds during early neural development of human embryonic stem cells

In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers

A competitive template RT-PCR to measure mRNA encoding for folate metabolizing enzymes, such as thimidylate synthase, in leukemia and colon cancer

Inhibition of Leishmania growth but not of phagocytic functions of macrophages by 5-fluorouracil in vitro

Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons

The use of morphometric and fractal parameters to assess the effects of 5-fluorouracil, interferon and dexamethasone treatment on colonic anastomosis healing: an experimental study in rats

Identification of teratogens in cell culture. II. Laboratory values of rat embryo midbrain studied by micromass test with penicillin G and 5-fluorouracil