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YOR129c, a new element interacting with Cnm67p, a component of the spindle pole body of Saccharomyces cerevisiae

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Wysocka M., Bialkowska A., Micialkiewicz A., Kurlandzka A.

Acta Biochimica Polonica

2003

tom 50

nr 3

The Saccharomyces cerevisiae spindle pole body (SPB) consists of numerous proteins forming the outer, inner and central plaques. The protein Cnm67 is an important component of the outer plaque. The C-terminus of this protein contains a determinant important for its SPB localization. We identified a protein encoded by YOR129c which interacts with this C-terminus in the two-hybrid system. YOR129c and CNM67 exhibit weak genetic interaction. The double deletion strain yor129cΔ cnm67Δ exhibits moderately increased resistance to 0.1 M LiCl and hygromycin B compared with the cnm67Δ single mutant. We propose that the YOR129c protein is an accessory factor associated with the cytoplasmic face of SPB and plays a role in cation homeostasis and/or multidrug resistance.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Bialkowska A.

1 Kurlandzka A.

1 Micialkiewicz A.

1 Wysocka M.

1 2003

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YOR129c, a new element interacting with Cnm67p, a component of the spindle pole body of Saccharomyces cerevisiae