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1
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LC determination and stability assessment of macrolide antibiotics azithromycin and spiramycin in bulk and tablet samples

100%
Mahmoudi A.
International Letters of Natural Sciences
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2015
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tom 47
Development and validation of rapid HPLC method for quantifying macrolide antibiotics azithromycin (AZI) and spiramycin (SPI) in bulk and tablet samples is described. Determination was performed on a reversed phase C18 ODB column (250×4.6 nm I.D) at ambient temperature, and employing a UV-detection set at 210 nm. The mobile phase consists of acetonitrile –2-methyl-2- propanol–hydrogenphosphate buffer, pH 6.2, with 1.8% triethylamine (32:8: up to 100, v/v/v), delivered at a flow-rate of 1.1 mL min-1. The assay is linear in concentration ranges of: 0.004–4.8 and 0.0003–1.2 mg mL−1 for azithromycin and spiramycin, respectively, with detection limit of 0.02% for SPI and 0.03% for AZI. Recovery experiments revealed recovery of 98.51–100.82%. The applicability of this method in stability assessment studies is evaluated.
2
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Azithromycin - new drug in giardiasis treatment

100%
Jeske J., Bergiel A., Kamerys J., Ochecka-Szymanska A.
Wiadomości Parazytologiczne
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1998
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tom 44
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nr 3
3

In vitro susceptibility of Helicobacter pylori strains to azithromycin

100%
Gosciniak G., Kovacic D., Przondo-Mordarska A.
Journal of Physiology and Pharmacology. Supplement
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1997
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tom 48
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nr 1
4

Azithromycin in the treatment of a dog infected with Giardia intestinalis

84%
Zygner W., Jaros D., Gojska-Zygner O., Wedrychowicz H.
Polish Journal of Veterinary Sciences
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2008
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tom 11
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nr 3
231-234
Giardia intestinalis infection is a common cause of diarrhoea in humans and other mammalian species throughout the world. This report describes a case of a dog suffering from diarrhoea, infected with G. intestinalis, effectively treated with azithromycin. Azithromycin is an azalide, semisynthetic macrolide antibiotic having a large spectrum of activity against bacterial pathogens and some protozoa. In this case, Giardia infection in a dog was confirmed by microscopic examination and PCR. Sequencing of the detected Giardia amplicon confirmed infection with assemblage A-I. The dog received azithromycin administered at dose of 10 mg/kg per os, once a day for 5 days. After the therapy, the diarrhoea stopped. Effectiveness of the treatment was also confirmed by PCR and microscopic examination. This is the first report on the therapy of canine giardiosis with azithromycin. It seems that azithromycin can be considered as promising antibiotic for the control of Giardia infection in dogs.
5

Susceptibility of Polish Bartonella henselae strains

84%
Podsiadly E., Zabicka D., Demkow U., Hryniewicz W., Tylewska-Wierzbanowska S.
Polish Journal of Microbiology
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2012
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tom 61
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nr 2
Due to the fastidious nature of B. henselae and the limited number of available isolates worldwide, there are few data on its in vitro susceptibility to antibiotics. We determined the minimal inhibitory concentrations (MIC) of ten antimicrobial agents against 11 feline isolates of B. henselae by Etest method. The lowest MICs were obtained for rifampicin = 0.002 mg/L. MICs of all isolates were < 0.016 mg/L for ampicilin, amoxicillin/clavulanic acid, tetracycline and ranged from 0.016 to 0.032 mg/L for azithromycin. The MICs for two tested fluoroquinolones: ciprofloxacin and levofloxacin ranged from 0.016 to 0.125 mg/L. The highest MICs were obtained for gentamicin ranging from 0.025 to 2.0 mg/L. Sulphonamide resistance genes sul 1, sul 2, sul 3 were not found in any of the tested isolates. Etest methodology seems to be a reliable method for determination of B. henselae susceptibility, however standardization is strongly desired.
6
Content available remote

Pleuritis as the first symptom of pulmonary embolism: a case report

67%
Doboszynska A., Koc M., Koc K., Swietlik E., Sosnowska E., Tomaszewska I.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
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