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In vitro immunomodulatory activity of the methanolic-water extract from Chinese wolfberry fruits [Lycium chinensis Mill.]

100%

Gasiorowski K., Tabaka H., Dzialo E., Noculak-Palczewska A., Lamer-Zarawska E.

Herba Polonica

2003

tom 49

nr 3-4

The influence of methanolic-water extract from Chinese wolfberry fruits (Lycium chinensis Mill.) on human lymphocyte proliferation and on frequencies of the main subpopulation of T lymphocytes after 72 h culture was studied. The extract mildly decreased frequency of proliferating lymphocytes while it markedly increased the CD4/CD8 ratio; the last effect stems from its activity on elevation of CD4+ cells number and lowering of CD8+ cell numbers. Impact of the extract on free radical generation by granulocyte samples in vitro included an increase of free radical level in non-stimulated granulocytes and a decrease of free radicals in granulocyte samples stimulated with the standard activator (PMA). The results documented a complex in vitro immunomodulatory action of the extract.

Chemical characterisation of methanolic-water extracts from the fruit of acclimated Lycium chinense Mill.

84%

Noculak-Palczewska A., Matkowski A., Gasiorowski K., Tabaka H., Oszmianski J., Lamer-Zarawska E.

Herba Polonica

2004

tom 50

nr 1

Methanolic-water extracts of wolfberry fruit (Lycii Fructus) harvested from plants cultivated in Poland have been analysed chemically to reveal compounds responsible for the biological activity of the crude drug. The potential for the scavenging of free radicals has been tested by means of a DPPH spectrophotometric assay. In the extracts several compounds with potential antioxidant properties have been detected: L-ascorbic acid, tocopherols (a, ß and y), ß-carotene, as well as phenolic acids (gallic, protocatechic, caffeic, chlorogenic, neochlorogenic). A considerable free-radical scavenging activity was confirmed by a DPPH assay, with EC50 of the extract being 24.08 mg/l.

Ograniczanie wyników

2 Herba Polonica

2 Gasiorowski K.

2 Lamer-Zarawska E.

2 Noculak-Palczewska A.

2 Tabaka H.

1 Dzialo E.

1 Matkowski A.

1 Oszmianski J.

1 2004

1 2003

Wyniki wyszukiwania

In vitro immunomodulatory activity of the methanolic-water extract from Chinese wolfberry fruits [Lycium chinensis Mill.]

Chemical characterisation of methanolic-water extracts from the fruit of acclimated Lycium chinense Mill.