Wyniki wyszukiwania

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Isoforms of ER translocon protein Sec61 Alpha - differential expression and involvement in ERAD pathway

100%

Sowa N., Slominska-Wojewodzka M.

Acta Biochimica Polonica

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2018

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tom 65

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nr S2

2

EDEM3 overexpression in HEK293 cells - its role in ricin cytotoxicity and transport from the endoplasmic reticulum to the cytosol

81%

Sominska H., Nowakowska J., Slominska-Wojewodzka M.

Acta Biochimica Polonica

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2018

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tom 65

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nr S2

3

ER degradation-enhancing Alpha-mannosidase-like proteins (EDEMs) can regulate amyloid precursor protein (APP) level in HEK293 cells

81%

Nowakowska J., Czapiewska J., Slominska-Wojewodzka M.

Acta Biochimica Polonica

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2018

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tom 65

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nr S2

4

Non-random distribution of GATC sequences in regions of promoters stimulated by the SeqA protein of Escherichia coli

80%

Strzelczyk B., Slominska-Wojewodzka M., Wegrzyn G., Wegrzyn A.

Acta Biochimica Polonica

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2003

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tom 50

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nr 4

The SeqA protein of Escherichia coli is not only the main negative regulator of DNA replication initiation but also a specific transcription factor. It binds to hemi- methylated GATC sequences and, with somewhat different specificity, to fully methylated GATC regions. Recently, a microarray analysis was reported, in which transcriptomes of wild-type and AseqA strains were compared. Although in the ΔseqA mutant the levels of some transcripts were significantly decreased while certain transcripts were evidently more abundant relative to wild-type bacteria, no correlation between the presence of GATC motifs in promoter sequences and transcription activity was found. However, here we show that when larger DNA fragments, encompassing positions from -250 to +250 relative to the transcription start site, are analyzed, some common features of GATC distribution near the promoters activated by SeqA can be demonstrated. Nevertheless, it seems that the GATC pattern is not the only determinant of SeqA-dependence of promoter activity.

Ograniczanie wyników

4 Acta Biochimica Polonica

4 Slominska-Wojewodzka M.

2 Nowakowska J.

1 Czapiewska J.

1 Sominska H.

1 Sowa N.

1 Strzelczyk B.

1 Wegrzyn A.

1 Wegrzyn G.

3 2018

1 2003

Isoforms of ER translocon protein Sec61 Alpha - differential expression and involvement in ERAD pathway

EDEM3 overexpression in HEK293 cells - its role in ricin cytotoxicity and transport from the endoplasmic reticulum to the cytosol

ER degradation-enhancing Alpha-mannosidase-like proteins (EDEMs) can regulate amyloid precursor protein (APP) level in HEK293 cells

Non-random distribution of GATC sequences in regions of promoters stimulated by the SeqA protein of Escherichia coli