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1

Adaptation and immunogenicity of Cryptosporidium parvum to immunocompetent mice

100%
Matsuo T., Tsuge Y., Umemiya-Shirafuji R., Fujino T.
Acta Parasitologica
|
2014
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tom 59
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nr 1
The adaptation and immunogenisity of Cryptosporidium parvum isolated from Siberian chipmunks (SC1 strain) in immunocompetent (ICR) mice were examined. The oocysts were received to the severe combined immunodeficiency (SCID) mice by repeated passage. The oocysts collected from the 18th SCID mice were inoculated to 5 ICR mice. The mice began to shed oocysts from 6 days after inoculation, the patency was 5 days, and the maximum oocysts per gram of feces (OPG) value was 104. The maximum of OPG value was gradually increased by successive passage, and finally that in the 22nd mice reached 106 (patency: 11 days). It is considered that these results indicate completion of their adaptation to ICR mice. To examine the immunogenicity of C. parvum to ICR mice, 8 groups of 5 mice each were inoculated with 1.3 × 106 oocysts of SC1 strain, which were collected after adaptation to SCID mice. All groups shed oocysts from 6th day, and their patency was from 8 to 12 days. On the 21st day after the primary infection, these mice were challenged with 1.3 × 106 oocysts. No oocysts shed from any groups, although 2 control groups shed oocysts from the 6th day, and their OPG values were more than 106. These results suggest that this strain has strong immunogenicity against ICR mice. Therefore, the immunological healthy mice were considered a useful experimental model to investigate immunological and drug treatments in the strain of C. parvum.
2

Host specificity and in vivo infectivities of the mouse coccidian parasites Eimeria krijgsmanni

76%
Hashimoto K., Tanaka T., Matsubayashi M., Endo K., Umemiya-Shirafuji R., Matsui T.
Acta Parasitologica
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2014
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tom 59
|
nr 2
In the present study, infection experiments of E. krijgsmanni using various hosts were conducted to elucidate the host specificity among some animals and the infectivity to mouse strains. According to the results, the infection was not found in most animals, except for rats, in which some oocyst shedding was detected, and there was no significant difference in infectivity among mouse strains. Additionally, oocyst shedding was hardly detectable in a secondary infection to immunocompetent mice, although it was found in immunodeficient mice. These results indicated that only immunocompetent mice could develop adaptive immunity against reinfection by stimuli of the primary infection. Furthermore, the infection experiments were performed with splenic macrophage (Mφ)-depleted mice with a reagent and Beige (Bg) mice known to be a strain of mice with low NK cell activity. No significant effect was found in primary or secondary infections in the Mφ-depleted mice, whereas the mortality rate was clearly increased in Bg mice inoculated with a large number of oocysts. Their oocyst shedding was similar to that of immunocompetent hosts. Taken together, these results suggested that Mφ has only a minor role in the immune response, but the NK cell has an important function in resistance to primary infection of E. krijgsmanni.
3

Evaluation of Eimeria krijgsmanni as a murine model for testing the efficacy of anti-parasitic agents

64%
Takeo T., Tanaka T., Matsubayashi M., Tsujio M., Umemiya-Shirafuji R., Tsuji N., Fujisaki K., Matsui T., Matsuo T.
Acta Parasitologica
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2015
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tom 60
|
nr 2
4

Transovarial persistence of Babesia ovata DNA in a hard tick, Haemaphysalis longicornis, in a semi-artificial mouse skin membrane feeding system

51%
Umemiya-Shirafuji R., Hatta T., Okubo K., Sato M., Maeda H., Kume A., Yokoyama N., Igarashi I., Tsuji N., Fujisaki K., Inoue N., Suzuki H.
Acta Parasitologica
|
2017
|
tom 62
|
nr 4
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