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1

Interaction of anesthetic supplement thiopental with human serum albumin

100%
Khan S. N., Islam B., Rajeswari M. R., Usmani H., Khan A. U.
Acta Biochimica Polonica
|
2008
|
tom 55
|
nr 2
399-409
Thiopental (TPL) is a commonly used barbiturate anesthetic. Its binding with human serum albumin (HSA) was studied to explore the anesthetic-induced protein dysfunction. The basic binding interaction was studied by UV-absorption and fluorescence spectroscopy. An increase in the binding affinity (K) and in the number of binding sites (n) with the increasing albumin concentration was observed. The interaction was conformation-dependent and the highest for the F isomer of HSA, which implicates its slow elimination. The mode of binding was characterized using various thermodynamic parameters. Domain II of HSA was found to possess a high affinity binding site for TPL. The effect of micro-metal ions on the binding affinity was also investigated. The molecular distance, r, between donor (HSA) and acceptor (TPL) was estimated by fluorescence resonance energy transfer (FRET). Correlation between the stability of the TPL-N and TPL-F complexes and drug distribution is discussed. The structural changes in the protein investigated by circular dichroism (CD) and Fourier transform infrared (FT-IR) spectroscopy reflect perturbation of the albumin molecule and provide an explanation for the heterogeneity of action of this anesthetic.
2

Energy consumption and carbon dioxide emissions of residential buildings in Lahore, Pakistan

86%
Ghafoor G. Z., Sharif F., Khan A. U., Hayyat M. U., Farhan M., Shahzad L.
Polish Journal of Environmental Studies
|
2020
|
tom 29
|
nr 2
3

Brucellosis in Mirpur, Azad Kashmir Pakistan: a livestock threat for neighboring zones

72%
Mubeen H., Khan I., Saleem M. H., Akhtar R., Ali S., Saqib M., Khan A. U., Umar S.
Medycyna Weterynaryjna
|
2018
|
tom 74
|
nr 07
The objective of the present study was to determine the prevalence of brucellosis in household animals of Mirpur, Azad Kashmir due to its geographic importance. A total of 360 blood samples of cattle, buffaloes, sheep and goats were initially screened through Rose Bengal Plate test (RBPT) and then positive samples were subjected to Enzyme Linked Immunosorbent Assay (ELISA) for confirmation and quantification of antibody titers. Molecular confirmation of serologically positive samples was performed by real time polymerase chain reaction (PCR). RBPT and ELISA showed a total of 8.6% and 6.87% positive samples respectively. The species wise seropositivity by RBPT was greater in cattle followed by buffaloes, goats and sheep. Similarly ELISA showed more seropositivity in cattle than buffaloes, while sheep and goats were negative for brucellosis by ELISA. RT-PCR revealed 100% samples positive for Brucella abortus by species specific PCR. This study revealed the presence of Brucella abortus in Mirpur for the first time. Since brucellosis is listed in transboundary diseases, its presence in this geographically important region could be a potential threat for neighboring countries.
4

Gamma radiation treatment for reducing cytotoxicity and mutagenicity in industrial wastewate

72%
Iqbal M., Abbas M., Arshad M., Hussain T., Khan A. U., Masood N., Tahir M. A., Hussain S. M., Bokhari T. H., Khera R. A.
Polish Journal of Environmental Studies
|
2015
|
tom 24
|
nr 6
5

Pathological alterations in respiratory system during co-infection with low pathogenic avian influenza virus (H9N2) and Escherichia coli in broiler chickens

59%
Jaleel S., Younus M., Idrees A., Arshad M., Khan A. U., Ehtisham-ul-Haque S., Zaheer M. I., Tanweer M., Towakal F., Munibullah, Tipu M. Y., Sohail M. L., Umar S.
Journal of Veterinary Research
|
2017
|
tom 61
|
nr 3
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