Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Czy obecność pokarmu oraz sposób dawkowania mogą wpływać na skuteczność cimikoksybu u psów?

100%

Lebkowska-Wieruszewska B., Kowalski C. J., Kim T. W., Owen H., Yun H., Giorgi M.

Magazyn Weterynaryjny

2016

tom 25

nr 03

Wpływ pokarmu oraz sposobu dawkowania na farmakokinetykę cymikoksybu u psów

100%

Lebkowska-Wieruszewska B., Kowalski C. J., Kim T. W., Owen H., Yun H., Giorgi M.

Medycyna Weterynaryjna

2015

tom 71

nr 10

Cimicoxib (CX) is a new non-steroidal anti-inflammatory drug from the “coxib” family, designed for dogs. In the available literature there is little information on the pharmacokinetics of CX. The aim of this study was to evaluate the effect of food intake on the pharmacokinetic characteristics of cimicoxib. Additionally, the pharmacokinetic profile after the administration of precise doses of CX (2 mg/kg b.w.) and an approximate dose (i.e. 80 mg tablet for animals of about 40 kg) were estimated. CX concentrations were determined by a HPLC validated method. The results of pharmacokinetic analysis were similar in both studies, regardless of the dose and the degree of filling of the gastrointestinal tract (fasted, fed). In addition, we estimated the duration of the minimum effective concentration (MEC), which turned out to be similar for all the concentrations tested. The results show that neither small variations in dosage nor the presence of food in the gastrointestinal tract change the therapeutic efficacy of the analgesic in terms of its blood concentration.

Spatial and temporal changes of osteopontin in oxygen-glucose-deprived hippocampal slice cultures

84%

Lee J.-Y., Choi J.-S., Choi J.-Y., Shin Y.-J., Yun H., Cha J.-H., Chun M.-H., Lee M.-Y.

Acta Neurobiologiae Experimentalis

2010

tom 70

nr 1

We have examined the temporal changes and cellular localization of osteopontin (OPN) mRNA and protein in organotypic hippocampal slice cultures subjected to ischemia-like oxygen–glucose deprivation (OGD). The sequential induction pattern of OPN expression occurred in a time- and cell-dependent manner in hippocampal slice cultures after OGD. The early response consisted of neuronal and microglial OPN upregulation, followed by a later extended phase of expression in reactive astrocytes. OPN immunoreactivity after OGD matched the mRNA induction patterns. Activated microglia revealed OPN staining in focal deposits, whereas neurons and reactive astrocytes showed perinuclear staining with a punctate cytosolic pattern of OPN, typical of secreted proteins. These data demonstrated that the temporal and cellular patterns of OPN induction in reactive glial cells in this in vitro model closely correlated with that in the in vivo model, suggesting that OPN has a multifunctional role in the pathogenesis of ischemic injury.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Magazyn Weterynaryjny

1 Medycyna Weterynaryjna

3 Yun H.

2 Giorgi M.

2 Kim T. W.

2 Kowalski C. J.

2 Lebkowska-Wieruszewska B.

2 Owen H.

1 Cha J.-H.

1 Choi J.-S.

1 Choi J.-Y.

1 Chun M.-H.

1 Lee J.-Y.

1 Lee M.-Y.

1 Shin Y.-J.

1 2016

1 2015

1 2010

Wyniki wyszukiwania

Czy obecność pokarmu oraz sposób dawkowania mogą wpływać na skuteczność cimikoksybu u psów?

Wpływ pokarmu oraz sposobu dawkowania na farmakokinetykę cymikoksybu u psów

Spatial and temporal changes of osteopontin in oxygen-glucose-deprived hippocampal slice cultures