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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Comparative ultrastructural studies of the alterations to mouse hepatic parenchyma during Trichinella spiralis or Toxocara canis infection

100%
Dabrowska J., Dybicz M.
Annals of Parasitology
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2016
|
tom 62
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nr Suppl.
2

Shared makeup cosmetics as a route of Demodex folliculorum infections

81%
Sedzikowska A., Bartosik K., Przydatek-Tyrajska R., Dybicz M.
Acta Parasitologica
|
2021
|
tom 66
|
nr 2
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Molecular characterisation of Echinococcus granulosus sensu stricto cases in Polish patients

81%
Dybicz M., Borkowski P. K., Dabrowska J., Chomicz L.
Annals of Parasitology
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2016
|
tom 62
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nr Suppl.
4

The pattern of TEM alterations in the lung parenchyma during Trichinella spiralis or Toxocara canis infection

81%
Dabrowska J., Dybicz M., Walski M., Doligalska M.
Annals of Parasitology
|
2013
|
tom 59
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nr Suppl.
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Studies on prevalence of infection with Trichomonas tenax identified by molecular techniques - in respect to oral health of patients with various systemic disease requiring immunosuppressive therapy

71%
Dybicz M., Perkowski K., Sedzikowska A., Baltaza W., Chomicz L.
Annals of Parasitology
|
2018
|
tom 64
|
nr 3
Trichomonas tenax, cosmopolitan flagellate inhabiting human oral cavity, is the etiological agent of oral trichomonosis associated with gingival and periodontium deterioration. Purpose of this studies was to investigate the prevalence of infection with Trichomonas tenax identified by molecular techniques amplifying the region of ITS1-5.8S rRNA-ITS2 specific for T. tenax. The study included 498 persons: diabetic, renal transplant, rheumatoid arthritis patients and the control group. Prevalence of T. tenax in oral cavity was 10.2% in control group, 14.1% in diabetics, 12.0% in renal transplant patients and 14.0% in rheumatoid arthritis patients. Comparative assessment of results showed symptoms of gingiva and periodontium deteriorations, at varying intensity in patients with various systemic diseases; higher prevalence of the trichomonad infection was revealed in adults in all groups. Simultaneously, renal transplantation, diabetes, rheumatoid arthritis and related therapy do not affect T. tenax incidences and no increased risk of the infection has been observed in the patients; the permanent medication used due to main disease should be taken into consideration as likely inhibitory factor.
6
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Molecular determination of suspected alveolar echinococcosis requiring surgical treatment in human cases from Poland

71%
Dybicz M., Borkowski P. K., Padzik M., Baltaza W., Chomicz L.
Annals of Parasitology
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2018
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tom 64
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nr 4
In this study five cases of suspected alveolar echinococcosis from Poland in which surgical treatment was needed, previously diagnosed by means of imaging and serological techniques, were analyzed in terms to identify the causative agent. Samples of the parasite tissues taken perioperatively from the liver lesions were used for the histopathological and molecular examinations. The sequences of all isolates were identical to Echinococcus multilocularis; all nad1 sequences have been deposited in GenBank The histopathological examination revealed Passpositive fragments of laminated layers typical for E. multilocularis metacestode. Obtained results confirm that the use of imaging techniques only may be insufficient to diagnose alveococcosis thus the recognition of the zoonosis should base on several procedures; especially valuable are highly sensitive and specific molecular methods.
7
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Diagnostyka molekularna przypadkow bablowicy watroby

71%
Dybicz M., Cielecka D., Gierczak A., Rdzanek L., Michalowicz B.
Wiadomości Parazytologiczne
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2010
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tom 56
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nr 3
220
8

Molecular identification of human cystic echinococcosis in central Poland

71%
Dybicz M., Dabrowska J., Gierczak A., Rdzanek L., Michalowicz B.
Annals of Parasitology
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2013
|
tom 59
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nr Suppl.
9
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Molecular identification of Trichomonas tenax in the oral environment of domesticated animals in Poland – potential effects of host diversity for human health

61%
Dybicz M., Perkowski K., Baltaza W., Padzik M., Sedzikowska A., Chomicz L.
Annals of Agricultural and Environmental Medicine
|
2018
|
tom 25
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nr 3
10
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Evaluation of selected oral cavity microbiota – risk factors of management complications in patients with masticatory system disorders

61%
Zawadzki P. J., Perkowski K., Starosciak B., Dybicz M., Baltaza W., Pionkowski K., Chomicz L.
Annals of Parasitology
|
2016
|
tom 62
|
nr 1
The retrospective analysis of data on oral cavity clinical status in relation to microbiota species composition is presented. The research regards patients of different age, with and without congenital malformation, pretreatment assessed for occurrence of pathological changes in the masticatory system. Samples of the swabs collected from each patient (from dental plaque, periodontium and dental pockets) were used for identification of oral protozoans in wet slides and stained preparations; additionally, transmission electron microscope examination was performed. The material was used for in vitro cultures to identify bacteria strains. Clinically, intensity of tissue deteriorations was higher in patients with a congenital disease. Alive Trichomonas tenax and Entamoeba gingivalis, species with confirmed pathogenic impact on oral cavity and neighboring structures, were detected with higher prevalence in older patients. Enterococci, Staphylococcus aureus, various Enterobacteriaceae were more frequently detected in patients with somatic and mental retardations; in mouths of those patients, Klebsiella pneumonia and Pseudomonas aeruginosa opportunistic strains occurred. Masticatory system abnormalities favor colonization of oral cavity by exogenous species and dissemination of infections, especially dangerous for patients with congenital diseases. Oral microbiota assessment and preventive measures may be helpful to avoid subsequent peri-surgery complications.
11
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Evaluation of in vitro effects of selected physical and chemical agents on detected in Poland Acanthamoeba strains - factors of increasing threats for public health

61%
Baltaza W., Padzik M., Szaflik J. P., Perkowski K., Dybicz M., Chomicz L.
Annals of Parasitology
|
2019
|
tom 65
|
nr 1
Acanthamoeba keratitis, the vision-threatening corneal disease reported with increasing frequency in Poland is difficult to treat due to extremely high resistance of the amoeba cysts to chemicals. The agents of possible anti-amoebic activity are still tested. Pathogenic Acanthamoeba samples/isolates acquired from severe cases of keratitis examined by molecular techniques to determine genotypes, compared to one another as well as to the environmental Acanthamoeba castellanii Neff strain were included in the studies. These strains were in vitro examined in terms of their sensitivity/resistance to selected chemicals and tolerance to temperature changes. Samples of the strains cultivated in vitro under bacteria-free conditions were monitored during different growth phases. Higher amoebic population dynamics was observed in both pathogenic Acanthamoeba strains during transfer to 37°C. Agents tested influenced population dynamics in different degree; they showed amoebostatic or amoebicidal effects, however a tendency toward induction of encystment also appeared. Because activation of the dormant cysts can lead to repeated development of amoebae, very important is cysticidal efficacy of chemicals. Further in vitro investigations on various Acanthamoeba strains with different chemicals are still necessary.
12
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Amoebicidal or amoebostatic influence of disinfectants used in health facilities and laboratories on corneal strains of Acanthamoeba

61%
Baltaza W., Padzik M., Szaflik J. P., Dybicz M., Hendiger E., Chomicz L.
Annals of Parasitology
|
2017
|
tom 63
|
nr 3
Different Acanthamoeba species are amphizoic organisms distributed in wide range of habitats in natural and man-made environments; they are also detected on surfaces of equipment and accessories in health facilities. Some strains of the amoebae are causative agents of the vision-threatening human disease Acanthamoeba keratitis, mainly reported in contact lens wearers. An exceptional high resistance of Acanthamoeba trophozoites and particularly cysts to chemicals, disinfectants and drugs is believed as influencing difficulty resulting in unsuccessful therapeutic management. As Acanthamoeba keratitis is the serious medical problem worldwide, different chemicals with possible activity against environmental and clinical Acanthamoeba strains are tested. In our study, selected disinfectants used in health care settings and laboratories were tested and their efficacy against the corneal strains Acanthamoeba castellanii and A. polyphaga , and environmental A. castellanii Neff strain was assessed. Comparative assessment of results of the assays show that, apart from amoebistatic effects, the disinfectants indicated expected cysticidal efficacy.
13
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Comparative examination on selected amphizoic amoebae in terms of their in vitro temperature tolerance - a possible indirect marker of potential pathogenicity of Acanthamoeba strains

61%
Baltaza W., Padzik M., Szaflik J. P., Dybicz M., Grochowska A., Kuryłowicz A., Chomicz L.
Annals of Parasitology
|
2018
|
tom 64
|
nr 4
Acanthamoeba species are ubiquitous in natural and man-made environments worldwide; some strains are able to colonize human eyes as facultative parasites. It has been shown that environmental and clinical isolates/species of Acanthamoeba vary in their pathogenicity. In this study we examine and compare the in vitro effects of the changing temperature on the population dynamics of subsequent amoebic strains. Identification of Acanthamoeba strain by morphological and molecular methods and temperature assays were performed. Monitoring of the corneal and environmental strains showed changes in population densities and a termo-tolerance correlating with pathogenicity of amoebae. Comparative assessment of results indicated differences in viability of amoebic populations in exponential growth phase in vitro cultivation. The increased awareness of the threat is needed for better understanding of impact of factors examined on pathogenesis in human infected with Acanthamoeba strains.
14

Składniki mikrobiomu jamy ustnej jako czynniki ryzyka zakażeń lokalnych i uogólnionych u pacjentów bez oraz z wadami wrodzonymi narządu żucia

61%
Perkowski K., Zawadzki P. J., Starosciak B., Dybicz M., Padzik M., Marczynska-Stolarek M., Chomicz L.
Postępy Mikrobiologii
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2016
|
tom 55
|
nr 1
15
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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The confocal microscopy, the tool for rapid in vivo diagnosis of Acanthamoeba keratitis - usefulness and limitations

61%
Chomicz L., Izdebska J., Padzik M., Baltaza W., Pionkowski K., Jasniewska E., Dybicz M.
Annals of Parasitology
|
2016
|
tom 62
|
nr Suppl.
16
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Comparison of chlorhexidine disinfectant in vitro effect on environmental and ocular Acanthamoeba strains, the amoebic agents of human keratitis - an emerging sight-threatening corneal disease in Poland

61%
Padzik M., Baltaza W., Szaflik J. P., Hendiger E., Dybicz M., Chomicz L.
Annals of Parasitology
|
2018
|
tom 64
|
nr 3
Small amoebae belonging to the Acanthamoeba genus complete their life cycles in different environmental niches as free-living protists however some of them are facultative parasites that can cause severe disease in humans. The sight-threatening Acanthamoeba keratitis develops in immune-competent persons, mainly in contact lens wearers; it is detected with increasing frequency along with the spread of contact lens use. The high abundance of the amoebae in the environment is important for dispersion and transmission of the infections among humans. Emerging threats for the public health generated by these amoebae is the serious medical problem worldwide. Nonspecific symptoms, similar to those occurring in the other eye diseases, diagnostic mistakes, the delay of an appropriate treatment, an exceptional high resistance of the amoebae to chemicals and drugs result in a prolonged course of the disease and often unsuccessful therapeutic management. Thus, different chemicals are still examined for their potential activity in vitro against various species, strains/isolates of Acanthamoeba. As the prolonged therapy often induces encystation subsequently leading to excystment and recurrences of amoebic keratitis, apart from anti-amoebic activity, cysticidal effect of examined agents is desirable. In the present study, results of our comparative investigations showed that cationic antiseptic chlorhexidine digluconate indicated in vitro anti-amoebic effect on environmental Acanthamoeba castellanii Neff strain and pathogenic corneal Acanthamoeba polyphaga T4 genotype. Amoebostatic effect of the disinfectant was expressed in reduced number of surviving amoebae in comparison to the respective control cultures; simultaneously, despite prolonged incubation with the agent no stimulation of encystation was noted. The corneal strain was more resistant to the tested compound than the Neff strain. The cysticidal efficacy of chemicals is very expected, thus further in vitro studies on pathogenic Acanthamoeba strains with different application chemicals pattern are needed.
17
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

In vivo confocal microscopy and in vitro culture techniques as tools for evaluation of severe Acanthamoeba keratitis incidents

61%
Padzik M., Szaflik J. P., Baltaza W., Perkowski K., Dybicz M., Chomicz L.
Annals of Parasitology
|
2017
|
tom 63
|
nr 4
Amphizoic amoebae belonging to the genus Acanthamoeba are known as etiological agents of sightthreatening Acanthamoeba keratitis. The leading risk factor for the development of this serious human disease is contact lens wearing which popularity increases worldwide, also in Poland. The disease with active epithelial inflammations, corneal ulcers, including loss of the visual acuity is a serious medical problem as an emerging threat for the public health related to improper contact lens hygiene. The treatment of the amoebic keratitis is difficult, often unsuccessful due to delayed proper diagnosis. The clinical picture of the disease, often with severe course is nonspecific, similar to that occurring in viral, fungal or bacterial keratitis, thus clinical symptoms alone are not sufficient to identify the causative agent of the amoebic infection. Early diagnosis is decisive for the suitable therapeutic management and the treatment efficacy. In our studies, several complicated, difficult to treat Acanthamoeba keratitis incidences pertaining Polish patients using contact lenses have been retrospectively analyzed in terms of the usefulness of non-invasive methods of in vivo confocal microscopy and in vitro culture techniques applied for diagnosis. Hyper-reflective double-walled spherical Acanthamoeba cysts, with a more reflective outer wall were detected in the epithelium and anterior layers of the corneal stroma. In vivo confocal microscopy, if available, may be a valuable, sensitive tool for diagnosis in late identified severe infections mainly with strong viability strains, however confoscan may offer limited value at lowintensity amoebic infections. The microscopic visualization of amoebae in slides prepared directly from corneal scraping and laboratory examinations of specimens from in vitro cultivated corneal isolates allow to confirm or verify results of in vivo examinations, furthermore to identify directly the pathogens and to clarify previous misdiagnoses.
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