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Wpływ leczenia bisoprololem na wydzielanie insuliny, peptydu C (PPC), ghreliny i glukozo-zależnegoinsulinotropowego peptydu (GIP) u kobiet z nadciśnieniem pierwotnym

100%

Adamiec M., Sztefko K., Kawecka-Jaszcz K., Posnik-Urbanska A., Czarnecka D.

Diagnostyka Laboratoryjna

2007

tom 43

nr 3

The selected pathophysiological aspects of PPARs activation

100%

Kiec-Wilk B., Dembinska-Kiec A., Olszanecka A., Bodzioch M., Kawecka-Jaszcz K.

Journal of Physiology and Pharmacology

2005

tom 56

nr 2

Peroxisome proliferator activated receptors (PPARs) belong to a subfamily of transcription nuclear factors. Three isoforms of PPARs have been identified: alpha, ß/ and , encoded by different genes and distributed in various tissues. They play important roles in metabolic processes like regulation of glucose and lipid redistribution. They also have anti-atherogenic, anti-inflammatory as well as anti-hypertensive functions. In hypertension-induced cardiac hypertrophy, both PPARalpha and PPAR activation reveal cardio-protective effect. Despite these beneficial functions, several recent experimental reports point to the possibille unfavorable effects of PPARs activation in lipid metabolism (lipotoxicity) in cardiomyocytes, which can lead to pathologic cardiac hypertrophy in such diseases as diabetes type 2, metabolic syndrome or obesity. This paper reviews evidences and hypotheses about the new pathophysiological aspects of PPARs activation.

Ograniczanie wyników

1 Diagnostyka Laboratoryjna

1 Journal of Physiology and Pharmacology

2 Kawecka-Jaszcz K.

1 Adamiec M.

1 Bodzioch M.

1 Czarnecka D.

1 Dembinska-Kiec A.

1 Kiec-Wilk B.

1 Olszanecka A.

1 Posnik-Urbanska A.

1 Sztefko K.

1 2007

1 2005

Wyniki wyszukiwania

Wpływ leczenia bisoprololem na wydzielanie insuliny, peptydu C (PPC), ghreliny i glukozo-zależnegoinsulinotropowego peptydu (GIP) u kobiet z nadciśnieniem pierwotnym

The selected pathophysiological aspects of PPARs activation