Wyniki wyszukiwania

1

Nowotwory a starzenie.

100%

Balinska M., Brzezinska A., Winska P.

Postępy Biologii Komórki. Suplement

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2000

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tom 15

45-55

2

Cellular aspects of folate and antifolate membrane transport

100%

Brzezinska A., Winska P., Balinska M.

Acta Biochimica Polonica

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2000

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tom 47

|

nr 3

Folates one carbon carriers take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.

3

Thymidylate biosynthesis as a target in chemotherapy. Potential importance of a peculiar expression pattern of enzymes involved in thymidylate biosynthesis in nematodes

76%

Rode W., Dabrowska M., Golos B., Winska P., Jagielska E., Ciesla J., Zielinski Z.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

4

Synthesis and biological activity of Na-[4-[N-[[3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl]methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid

64%

Kusakiewicz-Dawid A., Bugaj M., Dzik J. M., Golos B., Winska P., Pawelczak K., Rzeszotarska B., Rode W.

Acta Biochimica Polonica

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2002

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tom 49

|

nr 1

2-Deamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) is a potent inhibitor of thymidylate synthase. Its analogue, Nα-[4-[N-[(3,4-dihydro 2-methyl-4 -oxo- 6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid, containing p-aminophenylacetic acid residue substituting p-aminobenzoic acid residue, was synthesized. The new analogue exhibited a moderately potent thymidylate synthase inhibition, of linear mixed type vs. the cofactor, N5,10 -methylenetetrahydrofolate. The K value of 0.34 uM, determined with a purified recombinant rat hepatoma enzyme, was about 30-fold higher than that reported for inhibition of thymidylate synthase from mouse leukemia L1210 cells by ICI 198583 (Hughes et al., 1990, J. Med. Chem. 33, 3060). Growth of mouse leukemia L5178Y cells was inhibited by the analogue (IC50 = 1.26 mM) 180-fold weaker than by ICI 198583 (IC50 = 6.9 uM).

Ograniczanie wyników

3 Acta Biochimica Polonica

1 Postępy Biologii Komórki. Suplement

4 Winska P.

2 Balinska M.

2 Brzezinska A.

2 Golos B.

2 Rode W.

1 Bugaj M.

1 Ciesla J.

1 Dabrowska M.

1 Dzik J. M.

1 Jagielska E.

1 Kusakiewicz-Dawid A.

1 Pawelczak K.

1 Rzeszotarska B.

1 Zielinski Z.

1 2003

1 2002

2 2000

Nowotwory a starzenie.

Cellular aspects of folate and antifolate membrane transport

Thymidylate biosynthesis as a target in chemotherapy. Potential importance of a peculiar expression pattern of enzymes involved in thymidylate biosynthesis in nematodes

Synthesis and biological activity of Na-[4-[N-[[3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl]methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid