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1

Elevated advanced oxidation protein products levels in patients with liver cirrhosis

100%
Zuwala-Jagiello J., Pazgan-Simon M., Simon K., Warwas M.
Acta Biochimica Polonica
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2009
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tom 56
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nr 4
679-685
Serum concentrations of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) were assessed with respect to functional compromise of liver, as determined by the Child-Pugh and MELD scores. Patients with decompensated liver cirrhosis (Child-Pugh B and C) exhibited significantly higher serum concentrations of AOPPs than both patients with compensated liver cirrhosis (Child-Pugh A) and controls. The levels of plasma AGEs in all liver cirrhotic patients were higher when compared with those with the controls and this difference was statistically significant. Plasma total antioxidant status of the patients was significantly lower than that of controls. Significant positive correlations between AOPPs level and the MELD score and between the oxidative stress index and the MELD score were found in all patients with liver cirrhosis. Altered AOPPs levels in decompensated patients may influence the potency of oxidative stress and the progression of liver disease.
2

Ischemia-modified albumin (IMA) is increased in patients with chronic hepatitis C infection and related to markers of oxidative stress and inflammation

100%
Zuwala-Jagiello J., Warwas M., Pazgan-Simon M.
Acta Biochimica Polonica
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2012
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tom 59
|
nr 4
Inflammation and oxidative stress have been reported in patients with chronic hepatitis C (CHC) infection, but their influence on ischemia-modified albumin (IMA) levels and diabetes prevalence remains unknown. Sixty-three CHC patients, 28 with diabetes, and 40 healthy controls were enrolled in the study. Circulating levels of oxidative stress markers [Nε-(carboxymethyl)lysine- advanced glycation end products (CML-AGEs) and advanced oxidation protein products-(AOPPs)], pro-inflammatory cytokines (interleukin-6, and tumor necrosis factor α), and high-sensitivity C-reactive protein (hsCRP) were assessed. Compared with the controls, the CHC patients with diabetes showed a significant increase in plasma concentrations of IMA, AOPPs, interleukin-6 and hsCRP (P < 0.05). The values of IMA and hsCRP were more elevated in patients with diabetes than without diabetes (both P < 0.01). The positive relationships were found between hsCRP and presence of diabetes, IMA (both P < 0.01) and AOPP levels (P < 0.05). CML-AGEs did not show any significant correlation with IMA, markers of inflammation and presence of diabetes. In conclusion, we have documented significant elevation in plasma levels of IMA and AOPPs in CHC patients. In addition, circulating IMA was associated with inflammation markers and diabetes prevalence. This observation suggests a relationship between IMA and inflammation in CHC patients with diabetes, which may represent one of the mechanisms involved in the accelerated atherosclerosis in this population.
3

Advanced oxidation protein products and inflammatory markers in liver cirrhosis: a comparison between alcohol-related and HCV-related cirrhosis

100%
Zuwala-Jagiello J., Pazgan-Simon M., Simon K., Warwas M.
Acta Biochimica Polonica
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2011
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tom 58
|
nr 1
Advanced oxidation protein products (AOPPs) are protein markers of oxidative stress with pro-inflammatory properties that accumulated in liver cirrhosis. In the present study, we investigated the association between chronic inflammatory response triggered by AOPPs and the severity of liver disease as assessed by the Child-Pugh score. Plasma concentrations of AOPPs and inflammatory markers such as C-reactive protein, tumor necrosis factor-α, and interleukin-6 were measured in 41 patients with HCV-related cirrhosis, 43 patients with alcohol-related liver cirrhosis (ALC), and in 30 age and sex matched controls. In comparison with controls, AOPPs were increased in HCV-related compensated (Child-Pugh A) and decompensated (Child-Pugh B-C) cirrhosis and in alcohol-related compensated cirrhosis. AOPPs level positively correlated with Child-Pugh score in alcohol-related cirrhosis but not in HCV-related cirrhosis and the correlation with the indices of chronic inflammation was stronger in ALC. In turn, AOPPs in HCV-related cirrhosis was related to inflammation to a lesser extent, but a significant correlation with antioxidant defense could be noted. In summary, liver cirrhosis was associated with increased formation of AOPPs, which differed between alcohol-related and HCV-related cirrhosis with respect to the relationship between AOPPs and antioxidant defense, stage of liver cirrhosis, and inflammatory response. The significant correlation between AOPPs accumulation and indices of chronic inflammation, more specifically TNF-α, suggests that oxidative stress may be a mediator of chronic inflammatory state in the early stage of alcohol-related cirrhosis.
4

Ocena aktywności reakcji wolnorodnikowych u chorych na marskość wątroby

76%
Zuwala-Jagiello J., Gorka J., Pazgan-Simon M., Simon K., Milczarska J., Warwas M.
Diagnostyka Laboratoryjna
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2007
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tom 43
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nr 3
5
Content available remote

Increased circulating endocan in patients with cirrhosis: relation to bacterial infection and severity of disease

76%
Zuwala-Jagiello J., Simon K., Kukla M., Murawska-Cialowicz E., Gorka-Dynysiewicz J., Grzybek E., Pazgan-Simon M.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 2
6
Content available remote

Serum endocan level in diabetes mellitus of patients with cirrhosis and risk of subsequent development of spontaneous bacterial peritonitis

76%
Zuwala-Jagiello J., Pazgan-Simon M., Simon K., Kukla M., Murawska-Cialowicz E., Grzebyk E.
Journal of Physiology and Pharmacology
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2019
|
tom 70
|
nr 3
7
Content available remote

Serum betatrophin and irisin levels in hepatocellular carcinoma

64%
Pazgan-Simon M., Zuwala-Jagiello J., Menzyk T., Bator M., Derra A., Lekstan A., Grzebyk E., Simon K., Kukla M.
Journal of Physiology and Pharmacology
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2020
|
tom 71
|
nr 1
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