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The toxic Doppelganger: on the ionic and molecular mimicry of cadmium

100%

Chmielowska-Bak J., Izbianska K., Deckert J.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

Cadmium is a toxic heavy metal which can cause numerous alterations in cell functioning. Exposure to cadmium leads to generation of reactive oxygen species, disorders in membrane structure and functioning, inhibition of respiration, disturbances in ion homeostasis, perturbations in cell division, and initiation of apoptosis and necrosis. This heavy metal is considered a carcinogen by the Agency for Toxic Substances and Disease Registry. At least some of the described toxic effects could result from the ability of cadmium to mimic other divalent ions and alert signal transduction networks. This review describes the role of cadmium mimicry in its uptake, reactive oxygen species generation, alterations in calmodulin, Wnt/β-catenin and estrogen signaling pathways, and modulation of neurotransmission. The last section is dedicated to the single known case of a favorable function performed by cadmium mimicry: marine diatoms, which live in zinc deficient conditions, utilize cadmium as a cofactor in carbonic anhydrase - so far the only described cadmium enzyme.

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The reactive nitrogen species affect potato immunity to Phytophthora infestans

100%

Arasimowicz-Jelonek M., Floryszak-Wieczorek J., Abramowski D., Izbianska K.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 3

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The influence of phenylpropanoid pathway metabolites on Lupinus luteus seedlings exposed to Pb stress

100%

Izbianska K., Arasimowicz-Jelonek M., Deckert J.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 3

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NADPH oxidase is involved in regulation of gene expression and ROS overproduction in soybean (Glycine max L.) seedlings exposed to cadmium

76%

Chmielowska-Bak J., Arasimowicz-Jelonek M., Izbianska K., Frontasyeva M., Zinicovscaia I., Guiance-Varela C., Deckert J.

Acta Societatis Botanicorum Poloniae

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2017

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tom 86

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nr 2

Cadmium-induced oxidative burst is partially mediated by NADPH oxidase. The aim of the present research was to evaluate the role of NADPH oxidase in soybeans’ response to short-term cadmium stress. The application of an NADPH oxidase inhibitor, diphenyleneiodonium chloride (DPI), affected expression of two Cd-inducible genes, encoding DOF1 and MYBZ2 transcription factors. This effect was observed after 3 h of treatment. Interestingly, Cd-dependent increases in NADPH oxidase activity occurred only after a period of time ranging from 6 and 24 h of stress. Stimulation of the enzyme correlated in time with a significant accumulation of reactive oxygen species (ROS). Further analysis revealed that pharmacological inhibition of NADPH oxidase activity during 24 h of Cd stress does not affect Cd uptake, seedling growth, or the level of lipid peroxidation. The role of NADPH oxidase in the response of soybean seedlings to short-term Cd exposure is discussed.

Ograniczanie wyników

2 BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

1 Acta Biochimica Polonica

1 Acta Societatis Botanicorum Poloniae

4 Izbianska K.

3 Arasimowicz-Jelonek M.

3 Deckert J.

2 Chmielowska-Bak J.

1 Abramowski D.

1 Floryszak-Wieczorek J.

1 Frontasyeva M.

1 Guiance-Varela C.

1 Zinicovscaia I.

1 2017

3 2013

The toxic Doppelganger: on the ionic and molecular mimicry of cadmium

The reactive nitrogen species affect potato immunity to Phytophthora infestans

The influence of phenylpropanoid pathway metabolites on Lupinus luteus seedlings exposed to Pb stress

NADPH oxidase is involved in regulation of gene expression and ROS overproduction in soybean (Glycine max L.) seedlings exposed to cadmium