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1

Geny, srodowisko a choroby mozgu

100%
Dziedzicka-Wasylewska M.
Wszechświat
|
2009
|
tom 110
|
nr 01-03
19-27
2

Effect of antidepressant drugs on the level of cAMP in the nucleus caudatus and nucleus accumbens septi of the rat

63%
Rogoz R., Dziedzicka-Wasylewska M.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
3

Geny a choroby mozgu

63%
Dziedzicka-Wasylewska M., Faron-Gorecka A.
Wszechświat
|
2003
|
tom 104
|
nr 01-03
18-24
4

The effect of prolonged administration of lithium on the level of dopamine D2 receptor mRNA in the rat striatum and nucleus accumbens

63%
Dziedzicka-Wasylewska M., Wedzony K.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 1
5

Effect of repeated administration of venlafaxine on the level of mRNA coding for dopamine D1 and D2 receptors in rat brain

51%
Rogoz Z., Dziedzicka-Wasylewska M., Goralska M., Maj J.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 3
6

Effect of acute treatment with antidepressant drugs on the reactivity of D3 dopaminergic and beta-adrenergic receptors in the rat brain

51%
Dziedzicka-Wasylewska M., Rogoz Z., Dlaboga D., Margas W.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 3
7

Chronic treatment with neuroleptics alters the level of NMDA receptor subunits in the rat brain: an in situ hybrydization study

51%
Pietraszek M., Wardas J., Dziedzicka-Wasylewska M., Ossowska K.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
8

Two antidepressant drugs, taneptine and fluoxetine influence the rat central dopaminergic receptorsautoradography and in situ hybridization study

51%
Dlaboga D., Rogoz Z., Maj J., Dziedzicka-Wasylewska M.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
9
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Content available

Czy powtarzalność badań z wykorzystaniem zwierząt laboratoryjnych jest w ogóle możliwa?

51%
Dziedzicka-Wasylewska M., Solich J., Kusmider M., Faron-Gorecka A.
Wszechświat
|
2020
|
tom 121
|
nr 10-12
10

Kompleks Tyrezjasza jako dylemat wspolczesnej genetyki na przykladzie choroby Huntingtona

51%
Dziedzicka-Wasylewska M., Siwanowicz J., Faron-Gorecka A.
Wszechświat
|
2004
|
tom 105
|
nr 01-03
32-39
11

In vitro fluorescence studies of transcription factor IIB-DNA interaction

51%
Gorecki A., Figiel M., Dziedzicka-Wasylewska M.
Acta Biochimica Polonica
|
2015
|
tom 62
|
nr 3
12

Reboxetine administered repeatedly influences the central dopaminergic system in the rat

51%
Margas W., Rogoz Z., Maj J., Dziedzicka-Wasylewska M.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
13

The effect of D380Y pathogenic mutation in human Yin Yang 1 on the protein’s structure and function

51%
Figiel M., Lakomska J., Dziedzicka-Wasylewska M., Gorecki A.
Acta Biochimica Polonica
|
2020
|
tom 67
|
nr 1
14

Effect of antisense oligodeoxynucleotides (ODNs) complementary to mRNA encoding dopaminergic D2 receptor, and the random sequence, administered bilaterally into the nucleus accumbens of the rat

51%
Margas W., Kolasiewicz W., Dziedzicka-Wasylewska M., Maj J.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 3
15
Content available remote

Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats

51%
Rogoz Z., Dlaboga D., Dziedzicka-Wasylewska M.
Journal of Physiology and Pharmacology
|
2003
|
tom 54
|
nr 2
In spite of intensive research, the problem of treating antidepressant-resistant depressive patients has not yet been solved. Our previous studies demonstrated that joint administration of a tricyclic antidepressant drug, imipramine (IMI) with the uncompetitive antagonist of NMDA receptors, amantadine (AMA), produced stronger "antidepressant" effect in the forced swimming test (Porsolt's test) than the treatment with either drug alone given. Since it has been suggested that dopamine receptors, among others, may play a role in anti-immobility effect of IMI, in the present study we examined the effect of AMA (10 mg/kg) and IMI (5 and 10 mg/kg) given separately or jointly, as a single dose or repeatedly (twice daily for 14 days) on the dopamine D2 and D3 receptors in the rat brain, using receptor autoradiography. Following repeated administration of AMA alone or given in combination with IMI (5 mg/kg), the binding of [3H]quinpirole (dopamine D2/D3 receptors agonist) was increased, and similar changes were observed at the level of mRNA encoding dopamine D2 receptors. We used [3H]7-OH-DPAT to selectively label the dopamine D3 receptors. This experiment has shown that AMA given repeatedly did not induce statistically significant changes in the D3 receptor binding, while IMI at both used doses, increased the [3H]7-OH-DPAT binding, and this effect was still observed after repeated joint administration of AMA with both doses of IMI. However, using both radioligands, we did not observe any synergistic or even additive effects in the binding studies after joint administration of AMA and IMI. Nevertheless, we can conclude that repeated administration of AMA, given together with IMI, induces the up-regulation of dopamine D2 and D3 receptors in the rat brain, and this effect may explain their synergistic action observed in the behavioral studies involving dopaminergic transmission.
16
Content available remote

Effect of tianeptine and fluoxetine on the levels of met-enkephalin and mRNA encoding proenkephalin in the rat

51%
Dziedzicka-Wasylewska M., Dlaboga D., Pierzchala-Koziec K., Rogoz Z.
Journal of Physiology and Pharmacology
|
2002
|
tom 53
|
nr 1
The purpose of the present study was to evaluate the effects of acute and repeated treatment with two antidepressant drugs (ADs)of opposite pharmacological profile,i.e. tianpetine (TIA,serotonin reuptake enhancer)and fluoxetine (FLU,serotonin reuptake inhibitor)on the levels of Met-Enkephalin,(Met-Enk,a member of opioid peptide family, which has been suggested to play a role in the mechanism of action ADs)as well as on mRNA coding for proenkephalin (mRNA PENK)in various regions of the rat brain, pituitary,adrenal glands and plasma.Male Wistar rats were treated acutely or repeatedly (10 mg/kg p.o.,twice daily for 14 days)with TIA or FLU.Tissue for biochemical experiments was taken 2 h after last dose of appropriate drug.The levels of Met-Enk were estimated by radioimmunoassay,mRNA PENK was measured using in situ hybridization.From the results obtained in the present study it may be concluded that repeated administration of TIA or FLU induced similar changes in the levels of Met- Enk in the rat hippocampus,striatum,hypothalamus and neurointermediate lobe of pituitary.Such an effect is interesting,especially if one takes into account the differences in pharmacological profile between these two antidepressant drugs.It may be suggested that serotonin level might not be crucial for inducing the alterations in the content of Met-Enk.Since we did not observe any changes in the levels of PENK mRNA in the studied rat brain regions after repeated administration of TIA or FLU,it seems that the observed changes in the levels of Met-Enk do not result from effects of these antidepressants on biosynthesis of PENK,but rather from alterations in the peptide release.Another interesting finding of the present study was that in the anterior lobe of pituitary,adrenal glands and plasma,repeated administration of TIA induced alterations in the contents of Met-Enk,while repeated administration of FLU remained without any effect.It is tempting to speculate that such a differentiation between the effects of these two antidepressants might be linked to the well known feature of TIA (but not FLU)which has been shown to reduce both basal and stress-evoked activity of the hypothalamic-pituitary-adrenal (HPA)axis.
17

Fluorescencyjne metody badania oligomeryzacji receptorów związanych z białkami G

45%
Grymek K., Gaska M., Lukasiewicz S., Gorecki A., Dziedzicka-Wasylewska M.
Postępy Biochemii
|
2008
|
tom 54
|
nr 4
18

Adaptive changes in dopaminergic transmission upon prolonged administration of lithium

45%
Dziedzicka-Wasylewska M., Mackowiak M., Fijal K., Wedzony K., Klimek V.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
19

Corticotrophin releasing hormone modulates morphine effect on the met-enkephalin activity in the hypothalamic-pituitary-adrenal axis in lambs

45%
Pierzchala-Koziec K., Scanes C. G., Dziedzicka-Wasylewska M., Wieczorek M., Oeltgen P.
Folia Biologica
|
2017
|
tom 65
|
nr 4
20

The role of dopamine D2, receptor in the behavioral effects of imipramine - study with the use of antisense oligonucleotides

45%
Maj J., Dziedzicka-Wasylewska M., Kolasiewicz W., Margas W., Rogoz Z.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
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