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1

Correlation between plasma VEGF and angiogenesis of skin and subcutaneous tissue cancer in dogs

100%
Sobczynska-Rak A.
Bulletin of the Veterinary Institute in Puławy
|
2009
|
tom 53
|
nr 3
The research was performed on tumour tissues removed from 42 dogs, as well as blood samples drawn from dogs suffering from skin and subcutaneous tissue tumours and healthy dogs comprising the control group. The tumour specimens were preserved in 10% buffered formalin for 24 h. The tumour types were classified according to the official WHO classification. Immunohistochemical staining was performed in order to render the vascular endothelium visible. In the quantitative analysis of the blood vessels, a system of computer assisted microscopic analysis was utilised. The blood was centrifuged and the obtained plasma was labelled for vascular endothelial growth factor (VEGF). The test results were read with the use of a TECAN microplate reader and Magellan 4.0 software, allowing for curvilinear characteristic. It was found that the level of the vascularisation of malignant tumours is higher than that of benign tumours, and correlates with a high level of VEGF in blood plasma.
2

Angiogeneza w nowotworach skory i tkanki podskornej psow

100%
Sobczynska-Rak A.
Medycyna Weterynaryjna
|
2009
|
tom 65
|
nr 02
110-114
The aim of the study was the evaluation of the degree of tumor vascularization in dogs. The examinations were performed on 42 tumors, taken surgically from dogs affected with skin and subcutaneous tissue tumors. Twenty three male and nineteen female mixed breed dogs aged 3 to 15 years were operated. The dogs had not been treated for neoplasma diseases earlier. The tumor samples were fixed in 10% buffered formalin for 24 hours, after which the tissues were dehydrated in increasing concentrations of alcohol and embedded in paraffin. The slides were stained with hematoxyline and eosine. The tumor type was determined according to the current WHO classification. For the endothelium vessel observations immunohistochemical staining was performed with the use of polyclonal antibody directed against the von Willebrand factor (FVIII). The estimation of blood vessel quantity was performed in a microscope equipped with a computer image analysis system. The itratumoral microvessel density was calculated in 10 selected areas. The average of microvessel density was 190 per 1 mm² in malignant tumors and 138/mm˛ in benign tumors. It was found that the degree of malignant tumor vascularization was much larger than that of the benign tumor. Tumor angiogenesis determination can be used for diagnosis, prognosis, as well as for the degree of malignancy classification and metastatic potential.
3
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Serum VEGF concentration in dogs diagnosed with chronic superficial keratitis

63%
Balicki I., Sobczynska-Rak A.
Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii
|
2013
|
nr 4
4

Helicobacter u zwierzat i ludzi

63%
Sobczynska-Rak A., Rozanska D.
Medycyna Weterynaryjna
|
2004
|
tom 60
|
nr 02
132-136
5

Pies ofiara klusownictwa

63%
Sobczynska-Rak A., Polkowska I.
Magazyn Weterynaryjny
|
2008
|
tom 17
|
nr 03
179-180
6

Metody stabilizacji zlaman kosci zuchwy

51%
Polkowska I., Sobczynska-Rak A., Silmanowicz P., Szyszkowska A.
Medycyna Weterynaryjna
|
2008
|
tom 64
|
nr 09
1083-1086
Mandible fractures in animals result mainly from traffic accidents, falling and biting by other animals. This paper presents clinical management of mandible fractures in animals. The most common methods of mandible fracture fixation with the use of interdental wire, intramedullary nails, bone plates and acrylic devices have been reviewed. In conclusion, methodological approach to mandible fracture fixation depends on the size of the bone defect as well as technical possibilities and the surgeon’s experience. The major condition of recovery is obtaining the mandible bone stabilisation and proper occlusion. The postoperative treatment is also very important: one should consider whether the muzzle, oropharyngeal tube etc. should be used. In order to prevent further complications, appropriate antibioticotherapy and regular hygiene of oral cavity should be applied.
7

Przypadek chloniaka zlosliwego jelita biodrowego u psa

51%
Sobczynska-Rak A., Polkowska I., Smiech A., Silmanowicz P.
Medycyna Weterynaryjna
|
2008
|
tom 64
|
nr 07
889-892
The occurrence of intestinal tumors is relatively seldom. The article describes a case of a dog’s ileal neoplasia. Symptoms like persistent diarrheas, significant body loss and reduced mobility occurred. Radiography of the abdomen revealed a tumor of 10 cm in diameter located in the left subcostal area. Blood results showed leukocytosis and an elevated activity of alkaline phosphatase. The tumor was removed during laparotomy, and a part of the jejunum was resected. Histopathology showed the presence of T-cell lymphosarcoma. The patient’s health deterioration came 4 months after the surgery. Repeated radiography and ultrasonography revealed secondary cancers in different organs. The dog was euthanased. Necropsy confirmed metastases in intestines, lungs, liver, and kidneys. Therapeutic procedures on malicious tumors of alimentary tract, including this case of ileal lymphosarcoma, are described.
8

Rak przelyku u psa - ocena endoskopowa i patomorfologiczna

51%
Sobczynska-Rak A., Lopuszynski W., Silmanowicz P., Piorkowski J.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 05
550-552
Neoplasms of the esophagus are very rare in dogs. They account for 0.5% of all tumors. In the presented case the development of carcinoma was latent. The first symptoms were hypersalivation, vomiting, the backward flow and difficulty in swallowing of solid food. Subsequently the dog wasn’t able to swallow fluids. Hyperleucocytosis, lymphocytosis, monocytosis, anemia and elevated alkaline phosphatase level in the serum suggested tumor growth. An esophagoscopy was conducted as was oesophagostenosis: a tumor with hemorrhagic focuses, ulcer formations and erosions were observed. The dog was subjected to euthanasia. Specimens for histological examination were taken. The histology and immunohistological analysis confirmed the diagnosis of squamosus cell carcinoma.
9
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Choroby przyzębia u psów

51%
Golynska M., Polkowska I., Sobczynska-Rak A.
Życie Weterynaryjne
|
2014
|
tom 89
|
nr 10
10

Rak plaskonablonkowy jamy ustnej u psa

51%
Sobczynska-Rak A., Polkowska I., Smiech A.
Magazyn Weterynaryjny
|
2009
|
tom 18
|
nr 07-08
784
11

Angiogenesis in malignant oral - cavity tumours in dogs

51%
Sobczynska-Rak A., Polkowska I., Smiech A., Sobolewska E.
Bulletin of the Veterinary Institute in Puławy
|
2009
|
tom 53
|
nr 3
The aim of this study was to determine the vascularisation level in malignant tumours of the oral cavity. The studied material comprised 10 samples of neoplastic tissue extracted from dogs with a suspicion of oral cavity carcinoma. The samples were collected from nine male and one female dogs of various breeds, aged between 6 and 16 years. The tumours were located within the areas of mandibular and maxillary gingiva. Tumour specimens were preserved in 10% buffered formalin for 24 h, embedded in paraffin, and then sections stained with haematoxylin and eosin were prepared. Tumour type was diagnosed according to the official WHO classification. In order to render the vascular endothelium visible, immunohistochemical staining was performed with the use of the polyclonal antibody against von Willebrand factor F VIII and DAKO EnVision system. In the quantitative analysis of the blood vessels displaying the FVIII factor expansion, a system of computer-assisted microscopic analysis was utilised. In ten microscopic fields the vessels were counted and a mean value per 1 mm² was calculated. The largest numbers of blood vessels were observed in squamous cell carcinomas. In the remaining tumours, the vessel count fluctuated between 78-97/mm² (mean 87). The conducted research indicated that angiogenesis in malignant tumours of the oral cavity has potential diagnostic application in determining the malignancy levels of neoplasms.
12

Angiogeneza w nowotworach - czynniki wpływające na rozwój sieci naczyniowej guza oraz ocena neoangiogenezy w preparatach histopatologicznych

51%
Sobczynska-Rak A., Silmanowicz P., Polkowska I.
Medycyna Weterynaryjna
|
2016
|
tom 72
|
nr 09
Angiogenesis involves the formation of capillaries on the basis of already existing blood vessels. It is a multistage process resultant from the combined influence of pro- and anti-angiogenic factors. It begins with the stimulation of endothelial cells and degeneration of the basilemma and extracellular matrix, followed by the proliferation of endothelial cells and eventually the formation of a new vessel. The final stage involves a synthesis of the vessel’s basilemma and incorporation of pericytes stabilizing the capillary tube. Any study of angiogenesis necessitates a direct assessment of tissue vascularisation and indirect assessment of the occurrence of pro-angiogenic factors. The degree of vascularisation is determined on the basis of the number of capillaries and endothelial cell concentrations per a surface unit of a given tissue or organ. The same is achieved by staining histopathological samples with immunohistochemical methods using panendothelial antibodies: anti FVIII, anti-CD31 and anti CD34. The antibodies identifying proliferating endotelial cells are also specific to the evaluation of neoangiogenesis. The same include monoclonal antibodies: E9 and TEC-11. The quantitative analysis of blood vessel density in tumor tissue (MVD – microvessel density) is performed with the Weidner method. The total microvascular area (TVA) is also considered a significant angiogenic factor. The assessment of the relative surface area of capillaries within a tumor is performed using Chalkley’s method, vessel branching count (VBC) and angiogenic index. Indirect methods of angiogenesis assessment involve the determination of angiogenic cytokine production and the expression of their cellular receptors. The study of modulators and assessment of angiogenesis may facilitate more efficient tumor diagnostics and therapy
13

Angiogeneza w nowotworach zlosliwych sledziony u psow

51%
Sobczynska-Rak A., Silmanowicz P., Sobolewska E.
Medycyna Weterynaryjna
|
2009
|
tom 65
|
nr 10
693-696
The aim of the study was to determine the level of vascularization of neoplastic and healthy splenic parenchyma tissue in dogs. The first research group comprised spleen samples with diagnosed tumor changes extracted during splenectomy. Four male and five female dogs, aged between 8 and 13 years and of various races, were operated on. The second group comprised 10 samples of healthy spleen tissue extracted post-mortem. After staining with haematoxylin and eosin, the samples were diagnosed and the tumor type classified according to the official WHO classification. In order to render the vascular endothelium visible, immunohistochemical staining was performed with the use of the polyclonal antibody against the von Willebrand factor F VIII and the DAKO EnVision system. Angiogenesis that was observed in malignant spleen cancer tissue was intensified in comparison to that in healthy perenchyma tissue. The mean vascular density observed in malignant splenic tumors was 87 capillary vessels/mm². The mean vessel density was 60/mm² in lymphomas, while in angiosarcomas it averaged 108/mm². In healthy splenic tissue the observed mean vascular density was 14 vessels/mm². The highest vascular density was noted in tumors with metastases to other abdominal cavity organs (mean - 132 vessels/mm²). The observations may provide practitioners with a valuable prognostic insight into the potential danger of metastasis.
14

Leczenie operacyjne torbieli prostaty u psa

51%
Sobczynska-Rak A., Debiak P., Polkowska I.
Weterynaria w Praktyce
|
2010
|
tom 07
|
nr 07-08
15

Chirurgiczne leczenie złamania żuchwy i szczęki u psa

51%
Polkowska I., Sobczynska-Rak A., Komsta R.
Magazyn Weterynaryjny
|
2012
|
tom 21
|
nr 08
16

Problem ruchomości zębów w chorobach przyzębia u psów - opis przypadków

51%
Golynska M., Polkowska I., Sobczynska-Rak A., Kalbarczyk G.
VetTrends. Specjalistyczny Magazyn Lekarzy Weterynarii
|
2019
|
nr 3
17

Nowotwory jamy ustnej - klasyfikacja i leczenie

51%
Polkowska I., Putowska K., Golynska M., Sobczynska-Rak A.
Magazyn Weterynaryjny
|
2016
|
tom 25
|
nr 06
18

Vascular endothelial growth factor in prognosis of splenic malignant tumours in dogs

51%
Sobczynska-Rak A., Polkowska I., Brodzki A.
Bulletin of the Veterinary Institute in Puławy
|
2014
|
tom 58
|
nr 2
The aim of the study was to determine the levels of the vascular endothelial growth factor (VEGF) in the serum of dogs suffering from splenic malignant tumours, prior to splenectomy, as well as three and six months after the surgery. Tumours and blood samples were collected from 10 dogs of various breeds, aged between 7 and 13 years, and from 10 control animals. Tumour sections were fixed in 10% buffered formalin for 24 h. T he type of tumour was determined according to the WHO classification. Blood samples were centrifuged and the obtained sera were subjected to immunoenzymatic assays to determine the VEGF levels. The median of VEGF levels in the serum of dogs suffering from splenic malignant tumours was 37.85 pg/mL (15.40-107.18 pg/mL). The highest values were observed in dogs with confirmed metastases (107.18 pg/mL and 65.43 pg/mL). The VEGF values in control group were between 0.1 pg/mL and 13.04 pg/mL. A comparative analysis of the VEGF levels against the animals' survival time indicated that VEGF overexpression may serve as a prognostic factor in cases of malignant tumours of the spleen.
19

Występowanie, etiologia i antyhormonalne leczenie guzów okolicy odbytu u psów samców

45%
Brodzki A., Sobczynska-Rak A., Brodzki P., Tatara M. R., Silmanowicz P.
Medycyna Weterynaryjna
|
2014
|
tom 70
|
nr 10
The aim of the study: Perianal gland tumors in dogs are the third most prevalent tumors among all neoplastic diseases in males, and are considered a serious health impairment. It has been shown that perianal gland tumors are hormone-dependent, and the most frequently diagnosed type of these tumors are adenomas. The aim of the study was to evaluate the occurrence of perianal tumors in dogs in the Lublin region. Moreover, dogs with perianal gland tumors were subjected to antihormonal treatment. Materials and methods: This study involved the use of both Tamoxifen, as an antiestrogen, and Androcur, as an antiandrogen. Tamoxifen and Androcur were administered on the basis of sex hormone levels in the serum of the dogs. The study was performed on 45 male dogs aged 8-17 years, which suffered from perianal tumors. The diagnostic procedure was based on the histopathological examination of biopsies and on serum 17β-estradiol and testosterone concentrations determined by the ELISA method. In all experimental groups, 27 cases were diagnosed as adenoma (non-malignant tumors), 14 dogs suffered from epithelioma (low malignancy), and 4 patients had carcinoma (malignant tumors). Basic antihormonal treatment lasted for one month. Dogs with an elevated 17β-estradiol level underwent antiandrogen treatment, whereas an increased concentration of testosterone was the diagnostic criterion for antiandrogen treatment. Results: The antihormonal therapy of dogs with adenoma was effective in 90% of cases, and there was no recurrence of the disease during the 6-month period of observation. In 10% of adenoma cases, the size of perianal tumors was reduced significantly, and there was no bleeding. In such cases, the antihormonal treatment was prolonged for another two weeks. Eventually, all adenoma tumors disappeared completely, and the disease did not recur. In the case of epithelioma, the treatment was effective in 70% of patients, whereas in the remaining 30% of animals the size of tumors was significantly reduced. However, in the latter group, the extension of therapy by 2 weeks did not eliminate neoplastic changes. During the 6-month period of clinical observation, 60% of epithelioma cases showed recurrence. The antihormonal treatment of dogs with carcinoma resulted only in a reduced size of perianal tumors. In all such cases, the recurrence of neoplastic disease was observed with the following rapid growth of the tumors. Conclusions: This study has shown that antihormonal treatment was the most effective in dogs suffering from adenoma, less effective in patients with epithelioma, and the least effective in those with carcinoma.
20

Mięśniakomięsak jako rzadki nowotwór pęcherza moczowego - opis przypadku

45%
Sobczynska-Rak A., Polkowska I., Zylinska B., Smiech A., Lojszczyk-Szczepaniak A.
Medycyna Weterynaryjna
|
2017
|
tom 73
|
nr 07
Urinary bladder tumours account for approximately 1% of all tumours in dogs. The majority of them are epithelial in origin and malignant. Transitional cell carcinoma (TCC) is the most commonly diagnosed tumour of the urinary bladder. Malignant mesenchymal tumours in humans and animals are far less frequent than epithelial ones. Malignant mesenchymal urinary bladder tumours are represented by rabdomyosarcoma (RMS) and leiomyosarcoma (LMS). LMS occurs in older dogs, aged 7-12 years, and originates from the urinary bladder trigone and urethra, thus disturbing the urinary flow. LMSs are usually invasive, with a tendency to metastasize rapidly to the regional lymph nodes or abdominal organs, such as the liver, pancreas, kidneys, intestines and omentum. The aim of this report is to describe the clinical presentation, diagnostic approach and surgical treatment of the urinary bladder leiomyosarcoma that occurred in a Bernese Mountain Dog. The paper also highlights the latest diagnostic techniques for urinary bladder tumour detection, general rules of surgical resection and chemotherapy.
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