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1

Amyotrophic lateral sclerosis:how far away are we from the Charcot description?

100%
Kwiecinski H., Janik P.
Acta Neurobiologiae Experimentalis
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2006
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tom 66
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nr 4
2
Content available remote

Evaluation of matrix metalloproteinases in serum of patients with amyotrophic lateral sclerosis with pattern recognition methods

71%
Sokolowska B., Jozwik A., Niebroj-Dobosz I., Janik P., Kwiecinski H.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 5
3

ApoE polymorphism in Polish patients with Alzheimer's disease

71%
Lalowski M. M., Czyzewski K., Pfeffer A., Barcikowska M., Kwiecinski H.
Acta Neurobiologiae Experimentalis
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1998
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tom 58
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nr 1
4

Muscle pathology in myotonic dystrophy: light and electron microscopic investigation in eighteen patients

61%
Nadaj-Pakleza A., Lusakowska A., Sulek-Piatkowska A., Krysa W., Rajkiewicz M., Kwiecinski H., Kaminska A.
Folia Morphologica
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2011
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tom 70
|
nr 2
Myotonic dystrophy (DM) is the most common muscular dystrophy in adults. Two known genetic subtypes include DM1 (myotonic dystrophy type 1) and DM2 (myotonic dystrophy type 2). Genetic testing is considered as the only reliable diagnostic criterion in myotonic dystrophies. Relatively little is known about DM1 and DM2 myopathology. Thus, the aim of our study was to characterise light and electron microscopic features of DM1 and DM2 in patients with genetically proven types of the disease. We studied 3 DM1 cases and 15 DM2 cases from which muscle biopsies were taken for diagnostic purposes during the period from 1973 to 2006, before genetic testing became available at our hospital. The DM1 group included 3 males (age at biopsy 15–19). The DM2 group included 15 patients (5 men and 10 women, age at biopsy 26–60). The preferential type 1 fibre atrophy was seen in all three DM1 cases in light microscopy, and substantial central nucleation was present in two biopsies. Electron microscopy revealed central nuclei in all three examined muscle biopsies. No other structural or degenerative changes were detected, probably due to the young age of our patients. Central nucleation, prevalence of type 2 muscle fibres, and the presence of pyknotic nuclear clumps were observed in DM2 patients in light microscopy. Among the ultrastructural abnormalities observed in our DM2 group, the presence of internal nuclei, severely atrophied muscle fibres, and lipofuscin accumulation were consistent findings. In addition, a variety of ultrastructural abnormalities were identified by us in DM2. It appears that no single ultrastructural abnormality is characteristic for the DM2 muscle pathology. It seems, however, that certain constellations of morphological changes might be indicative of certain types of myotonic dystrophy. (Folia Morphol 2011; 70, 2: 121–129)
5

Temporal training improves both auditory comprehension and speech production in aphasic patients

51%
Oron A., Moczulska A., Lewandowska M., Skolimowska J., Pilczuk B., Domitrz I., Kwiecinski H., Szelag E.
Acta Neurobiologiae Experimentalis
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2011
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tom 71
|
nr S
Temporal information processing (TIP) is a well known neural process that underlies many aspects of human cognition, e.g., speech comprehension and speech production. The specific disorders of these language functions result from left hemispheric brain damage. A lot of literature data, as well as earlier experiments performed in our Laboratory have indicated that specific temporal training improves both TIP and auditory comprehension. The aim of this study was to test whether such a training in aphasic patients influences selectively speech reception, or also speech production. We compared performance of ten aphasic subjects before and after the training. Patients attended 16 training sessions (3 sessions a week, 45 minutes each). The training task was to indicate the temporal-order of two sounds presented to both ears in rapid succession. The task difficulty was adjusted adaptively, according to subject’s performance. Before and after the training both TIP abilities (temporal-order threshold measuring for two monaurally presented clicks) and language skills were tested. Language tests comprised global auditory comprehension and phonemic hearing on word and sentence levels, moreover, naming and verbal fluency. The preliminary results showed that our temporal training improved both auditory speech comprehension and speech production. These results indicate that temporal mechanisms underlying both receptive and expressive language functions can be ameliorated by the specific temporal training in milliseconds time domain. Supported by 507/1/N-DFG/2009/0.
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