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DNA ploidy assessment method applied to primary breast carcinoma FNA biopsies

100%

Czuba A., Lange D., Chmielik E., Woloszynska K., Wojciechowska E., Snietura M., Liszka J.

Folia Histochemica et Cytobiologica

2002

tom 40

nr 2

Rat spleen in the course of Babesia microti invasion: histological and submicroscopic studies

84%

Okla H., Jasik K. P., Urbanska-Jasik D., Slodki J., Rozwadowska B., Grelowski M., Chmielik E., Slodki A., Albertynska M., Grajoszek A.

Acta Protozoologica

2017

tom 56

nr 2

VDR gene single nucleotide polymorphisms and their association with risk of oral cavity carcinoma

68%

Malodobra-Mazur M., Paduch A., Lebioda A., Konopacka M., Rogolinski J., Szymczyk C., Wierzgon J., Maciejewski A., Chmielik E., Jonkisz A., Poltorak S., Dobosz T.

Acta Biochimica Polonica

2012

tom 59

nr 4

Vitamin D3 (1,25(OH)2D3 (1,25-dihydroxyvitamin D3)) is a hormone playing a crucial role in numerous biological processes in the human body, including induction and control of cell proliferation and differentiation. Numerous data relate the vitamin D3 level with various types of cancer. It has been suggested that SNPs in the vitamin D3 receptor (VDR) gene might influence both the risk of cancer occurrence and cancer progression. The aim of this study was to search for genetic correlations between individual SNPs in the VDR gene and the risk of oral cavity carcinoma. Two SNPs were selected based on the literature and our previous results. Seventy-three patients with squamous cell carcinoma of the head and neck and one hundred control subjects were investigated. Two SNPs in the VDR gene were genotyped in minisequencing reactions followed by capillary electrophoresis. Hardy-Weinberg equilibrium (HWE), the χ2 test and logistic regression were used for statistical analysis. The SNP rs2238135 in the VDR gene displayed statistical differences in frequency between the tested groups (p=0,0007). Furthermore, the G/C genotype of the rs2238135 in the VDR gene was characterized by a 3.16 fold increased risk of oral cavity carcinoma. The obtained results provide evidence for a genetic association between rs2238135 in the VDR gene and the occurrence and risk of oral cavity cancer.

BRCA1, BRCA2 and TP53 mutations in breast and ovarian cancer cases from Upper Silesia in Poland

68%

Zientek H., Jasinska A., Rusin M., Kozlowski P., Sobczak K., Sikorska A., Kwiatkowska E., Gorniak L., Kalinowska E., Rogozinska-Szczepka J., Utracka-Hutka B., Wloch J., Chmielik E., Sieminska M., Krzyzosiak W., Grzybowska E.

Folia Histochemica et Cytobiologica. Supplement

2001

tom 39

nr 1

Ratio of proliferation markers and HSP90 gene expression as a predictor of pathological complete response in breast cancer neoadjuvant chemotherapy

60%

Jarzab M., Kowal M., Bal W., Oczko-Wojciechowska M., Rembak-Szynkiewicz J., Kowalska M., Stobiecka E., Chmielik E., Tyszkiewicz T., Kaszuba M., Nowicka E., Lange B., Czarniecka A., Krajewska J., Dyla A., Dobrut M., Lange D., Jarzab B., Bobek-Billewicz B., Tarnawski R.