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1

Effect of L- and D-isomers of ascorbic acid on the levels of 5-methylcytosine and its epigenetic derivatives generated by TET family proteins in the genome of established, human cancer cell lines

100%
Gawronski M., Starczak M., Modrzejewska M., Gackowski D.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
2

Severe oxidative stress is associated with non-small cell lung cancer development

100%
Gackowski D., Kowalewski J., Siomek A., Olinski R.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
3

Cellular level of 8-oxo-2'-deoxyguanosine in DNA does not correlate with urinary excretion of the modified base nucleoside

100%
Foksinski M., Gackowski D., Rozalski R., Olinski R.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr 2
We assessed a relationship between the level of 8-oxodG in leukocyte DNA measured with the high performance liquid chromatography with electrochemical detection (HPLC/EC) technique and urinary excretion of the modified nucleoside/base ana­lysed with a recently developed methodology involving HPLC prepurification fol­lowed by gas chromatography with isotope dilution mass spectrometric detection. No correlation was found between these markers of oxidative DNA damage commonly used in epidemiological studies. Several possible explanations of this finding are dis­cussed.
4

Background level of 8-oxo-2'-deoxyguanosine in lymphocyte DNA does not correlate with the concentration of antioxidant vitamins in blood plasma

100%
Gackowski D., Ciecierski M., Jawien A., Olinski R.
Acta Biochimica Polonica
|
2001
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tom 48
|
nr 2
An tioxidantvita mins, being effective free radical scavengers, can protect cellular DNA from ox i da tive dam age. Therefore, in the pres ent study we re port on the re la- tion ship be tween basal level of 8-oxo-2 -deoxyguanosine in hu man lym pho cyte DNA and the concentration of antioxidant vitamins (A, C and E). The average level of 8-oxo-2 -deoxyguanosine in lymphocytes of the studied group (15 males and 20 fe­males) was 9.57 per 106 dG mol e cules. The en dog e nous level of ascor bic acid (vi ta min C) in the plasma was, on av er age, 56.78 uM, while the mean con cen tra tions of retinol (vi ta min A) and α-tocopherol (vi ta min E) were 1.24 uM and 25.74 uM, re spec tively. No correlations were found between individual 8-oxo-2 -deoxyguanosine levels in lymphocyte DNA and en dog e nous con cen tra tion of the vi ta mins.
5

Oxidative DNA damage; assessment and meaning in some human pathologies

88%
Gackowski D., Siomek A.-B., Rozalski R., Foksinski M., Olinski R.-S.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr Supplement 4
6

A simple UPLC-UV method for normalization of cellular concentration of metabolites involved in an active DNA demethylation process

88%
Modrzejewska M., Gawronski M., Starczak M., Foksinski M., Gackowski D.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
7

Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?

88%
Olinski R., Gackowski D., Rozalski R., Foksinski M., Bialkowski K.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
8

Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients

88%
Gackowski D., Kruszewski M., Banaszkiewicz Z., Jawien A., Olinski R.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 1
Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carci­noma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which suggests that changes in iron metabolism restrict iron availability for tumour cells and as consequence, slow their growth.
9

High concentrations of excised oxidative DNA lesions in human cerebrospinal fluid

76%
Rozalski R., Winkler P., Gackowski D., Paciorek T., Kasprzak H., Olinski R.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
10

Oxidative damage to DNA and antioxidant status in aging and age-related diseases

64%
Olinski R., Rozalski R., Gackowski D., Foksinski M., Guz J., Dziaman T., Szpila A., Siomek A.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
11

Effects of basal level of antioxidants on oxidative DNA damage in humans

64%
Foksinsk M., Gackowski D., Rozalski R., Guz J., Siomek A. G., Dziaman T., Jurgowiak M., Olinski R. S.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr Supplement 4
12

Oxidative stress and human ageing

64%
Siomek A., Gackowski D., Rozalski R., Dziaman T., Szpila A., Guz J., Foksinski M., Jurgowiak M., Olinski R.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
13

Oxidative damage to DNA and antioxidant status in aging and age-related diseases

64%
Olinski R., Siomek A., Rozalski R., Gackowski D., Foksinski M., Guz J., Dziaman T., Szpila A., Tudek B.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr 1
Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegenerative and cardiovascular diseases. It is, however, possible that a number of short-comings associated with gaps in our knowledge may be responsible for the failure to produce definite results when applied to understanding the role of DNA damage in aging and age-related diseases.
14

Profile of the products of active DNA demethylation pathways in leukocytes of breast and colon cancer patients

52%
Starczak M., Zarakowska E., Modrzejewska M., Dziaman T., Szpila A., Linowiecka K., Szpotan J., Gawronski M., Banaszkiewicz Z., Zurawski B., Urbanowska-Domanska O., Foksinski M., Olinski R., Gackowski D.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
15

Dynamics of estrogen-induced oxidative stress

52%
Kobiela J., Stefaniak T., Krajewski J., Kalinska-Blach B., Zurawa-Janicka D., Lachinski A., Gackowski D., Olinski R., Nowak J., Knap N., Lipinska B., Sledzinski Z., Wozniak M.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr 2
The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.
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