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Different phenotypes of intermittent and persistent respiratory allergy in Zagreb, Croatia

100%

Popovic-Grle S., Vrbica Z., Jankovic M., Klaric I.

Annals of Agricultural and Environmental Medicine

2009

tom 16

nr 1

137-142

CA-125 of fetal origin can act as a ligand for dendritic cell-specific ICAM-3-grabbing non-integrin

100%

Mitic N., Milutinovic B., Jankovic M.

Cellular and Molecular Biology Letters

2014

tom 19

nr 2

CA-125 (coelomic epithelium-related antigen) forms the extracellular portion of transmembrane mucin 16 (MUC16). It is shed after proteolytic degradation. Due to structural heterogeneity, CA-125 ligand capacity and biological roles are not yet understood. In this study, we assessed CA-125 as a ligand for dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN), which is a C-type lectin showing specificity for mannosylated and fucosylated structures. It plays a role as a pattern recognition molecule for viral and bacterial glycans or as an adhesion receptor. We probed a human DC-SIGN-Fc chimera with CA-125 of fetal or cancer origin using solid- or fluid-phase binding and inhibition assays. The results showed that DC-SIGN binds to CA-125 of fetal origin and that this interaction is carbohydrate-dependent. By contrast, cancerderived CA-125 displayed negligible binding. Inhibition assays indicated differences in the potency of CA-125 to interfere with DC-SIGN binding to pathogen-related glycoconjugates, such as mannan and Helicobacter pylori antigens. The differences in ligand properties between CA-125 of fetal and cancer origin may be due to specificities of glycosylation. This might influence various functions of dendritic cells based on their subset diversity and maturation-related functional capacity.

Ograniczanie wyników

1 Annals of Agricultural and Environmental Medicine

1 Cellular and Molecular Biology Letters

2 Jankovic M.

1 Klaric I.

1 Milutinovic B.

1 Mitic N.

1 Popovic-Grle S.

1 Vrbica Z.

1 2014

1 2009

Wyniki wyszukiwania

Different phenotypes of intermittent and persistent respiratory allergy in Zagreb, Croatia

CA-125 of fetal origin can act as a ligand for dendritic cell-specific ICAM-3-grabbing non-integrin