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Cytotoxic effect of organic dust extracts from different working environments: an in vitro assay

100%

Roepstorff V., Sigsgaard T.

Annals of Agricultural and Environmental Medicine

|

1997

|

tom 04

|

nr 2

2

Occupational asthma diagnosis workers exposed to organic dust

100%

Sigsgaard T., Schlunssen V.

Annals of Agricultural and Environmental Medicine

|

2004

|

tom 11

|

nr 1

The clinical evaluation of newly developed asthma in an adult should always include consideration of his occupational environment, since an abundance of different exposures, which are known causes of asthma, occur in workplaces. Two types of occupational asthma (OA) are distinguished, by whether they appear after a latency period: 1) Immunological OA, characterised by a latency period, caused by high and low-molecular-weight agents, with or without an IgE mechanism 2) Non-immunological, i.e. irritant induced asthma. The first step of the clinical evaluation is to confirm a diagnosis of asthma. Second step is to find out if there is a temporo-spatial distribution of symptoms and lung function that are indicative of OA. Third step is to determine if the disease at hand is an IgE or a non-IgE mediated disease. Last step is a challenge test that can be either unspecific, in order to assess the responsiveness of the lung, or specific challenge test, especially for the non-IgE mediated OA. The depth of clinical evaluation may vary from a situation in which a classical history confirms the clinical symptoms in e.g. a baker with confirmed allergy towards well-known allergens and a characteristic pattern in serial measurements of lung function, to more elaborate investigations in a situation with no or unknown allergen. In the latter situation, a specific challenge test might be necessary in order to find the offending agent. Finally, challenge tests are important in order to distinguish a causal relation from unspecific hyperresponsiveness in persons with pre-existing asthma. In these situations, extended sick leave and challenge tests can be the only way to find the answer.

3

Health effects of selected microbiological control agents. A 3-year follow-up study

81%

Baelum J., Larsen P., Doekes G., Sigsgaard T.

Annals of Agricultural and Environmental Medicine

|

2012

|

tom 19

|

nr 4

4

Non-malignant respiratory diseases and occupational exposure to wood dust. Part I. Fresh wood and mixed wood industry

81%

Jacobsen G., Schaumburg I., Sigsgaard T., Schlunssen V.

Annals of Agricultural and Environmental Medicine

|

2010

|

tom 17

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nr 1

15-28

5

Non-malignant respiratory diseases and occupational exposure to wood dust. Part II. Dry wood industry

81%

Jacobsen G., Schaumburg I., Sigsgaard T., Schlunssen V.

Annals of Agricultural and Environmental Medicine

|

2010

|

tom 17

|

nr 1

29-44

6

Asthma, toxic alveolitis and respiratory symptoms among 1005 young farmers and 412 non farming rurals

81%

Sigsgaard T., Hjort C., Omland O.

Annals of Agricultural and Environmental Medicine

|

1994

|

tom 01

|

nr 2

7

Biomonitoring and work related symptoms among garbage handling workers

81%

Sigsgaard T., Hansen J. C., Malmros P.

Annals of Agricultural and Environmental Medicine

|

1997

|

tom 04

|

nr 1

8

The shape of the maximum expiratory flow-volume curve reflects exposure in farming

81%

Omland O., Sigsgaard T., Pedersen O. F., Miller M. R.

Annals of Agricultural and Environmental Medicine

|

2000

|

tom 07

|

nr 2

9

Dermatoses among young farmers

81%

Hjort C., Omland O., Sigsgaard T.

Annals of Agricultural and Environmental Medicine

|

1994

|

tom 01

|

nr 2

10

Histamine responsiveness determined by partial flow-volume curves, atopy and smoking among 1005 young farmers

71%

Omland O., Hjort C., Sigsgaard T., Pedersen O. F., Miller M. R.

Annals of Agricultural and Environmental Medicine

|

1994

|

tom 01

|

nr 2

11

Change in airway inflammatory markers in Danish energy plant workers during a working week

61%

Zheng Y., Schlunssen V., Bonlokke J., Madsen A. M., Skov S., Sigsgaard T.

Annals of Agricultural and Environmental Medicine

|

2014

|

tom 21

|

nr 3

Introduction. It is well known that exposure to organic dust can cause adverse respiratory effect. The pathogen-associated molecular patterns (PAMPS) in the organic dust, such as endotoxin from Gram-negative bacteria cell wall and fungal components, can trigger the release of cytokine (e.g. Interleukin 1β (IL-1β)) and chemokine (e.g. Interleukin 8 (IL-8)) from the immune cells in the airways. Objective. To evaluate the potential inflammatory effects of organic dust exposure in energy plants in Denmark. Materials and methods. Nasal lavage (NAL) and exhaled breath condensate (EBC) were sampled at Monday morning (referred to as before work) and again at Thursday afternoon (referred to as after work). NAL IL-8, EBC pH, IL-1β concentration were measured. Personal exposure to endotoxin and dust was calculated from time spent on different tasks and measured average work area exposures. Results. Before work, workers from biofuel plants had a higher IL-1β and IL-8 concentration compared to conventional fuel plants (control group). Specifically, the IL-1β level of moderately and most exposed group, and IL-8 level of the least exposed group were higher compared to the control group. The changes of IL-1β, pH and IL-8 during a work week were not significant. Workers with rhinitis had a lower percentage change of IL-8 compared to healthy workers. Conclusions. An increased level of EBC IL-1β in biofuel energy plant workers before work indicated a chronic or sub-chronic inflammation. The percentage change of IL-8 was lower in workers with rhinitis compared to healthy workers.

12

A possible role of chitin in the pathogenesis of asthma and allergy

61%

Brinchmann B. C., Bayat M., Brogger T., Muttuvelu D. V., Tjonneland A., Sigsgaard T.

Annals of Agricultural and Environmental Medicine

|

2011

|

tom 18

|

nr 1

13

Can selectionexplain the protective effects of farming on asthma?

61%

Eduard W., Schlunssen V., Sigsgaard T., Omland O., Pearce N., Douwes J.

Annals of Agricultural and Environmental Medicine

|

2015

|

tom 22

|

nr 3

Introduction and objective. Reduced asthma and allergy risks in farmers have been ascribed to microbial exposures. However, selection may also play a role and this was assessed in two Scandinavian farming populations. Materials and methods. Asthma prevalence in 739 Danish farming students was compared to that of 1,105 siblings. 8,482 Norwegian farmers were also compared with 349 early retired farmers. Results. The prevalence of ever-asthma was 5.4% in farming students and 5.2% in siblings (OR 1.1; 95%CI 0.73–1.7). Current asthma in farmers was 3.0% compared to 6.3% in farmers who had retired early (OR 1.8, 95%CI 1.1–2.9). Adjustments for early retirement increased the asthma prevalence by 0.3–0.6%. Farmers who had changed production were more likely to have asthma (OR 9.8, 95% CI 6.0–16). Conclusions. No healthy worker selection into farming was observed and changes in asthma prevalence due to early retirement were small. Selection effects are therefore unlikely to explain the protective effects of farming on asthma.

14

Plasma C3D levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings

51%

Hoffmann H. J., Iversen M., Brandslund I., Sigsgaard T., Omland O., Oxvig C., Holmskov U., Bjermer L., Jensenius J. C., Dahl R.

Annals of Agricultural and Environmental Medicine

|

2003

|

tom 10

|

nr 1

Work in swine confinement buildings leads to an inflammatory response and may be associated with increased levels of acute phase proteins. We compared the inflammatory response of a control group of young former farm workers with age-matched former farm workers who had previously developed the lower airway symptoms of wheeze, cough, tightness of the chest during work in swine confinement buildings, and because of these symptoms had stopped work. Both groups were subjected to an experimental exposure in a swine confinement building for 3 hours. Complement activation and acute phase proteins were measured in blood samples and broncho-alveolar lavage. Plasma C3d levels correlated with respirable dust, significantly so for individual cases and for the whole cohort. Plasma C3, fibrinogen and alpha1-acid glycoprotein peaked 1 and 6 h after exposure start, mannan-binding lectin, C-reactive protein and alpha1-antitrypsin peaked after 2 h. Surfactant protein D (SP-D) and alpha2-macroglobulin were downregulated. In lavage, only SP-D, alpha2-macroglobulin and fibronectin were detected. FEV1, FVC, TLC and FEV25-75 did not vary during exposure. There was complement activation in response to respiratory dust, more so amongst cases than in the control group. Acute exposure, with work related levels of organic dust containing endotoxin, leads to a weak systemic inflammatory response.

Ograniczanie wyników

Cytotoxic effect of organic dust extracts from different working environments: an in vitro assay

Occupational asthma diagnosis workers exposed to organic dust

Health effects of selected microbiological control agents. A 3-year follow-up study

Non-malignant respiratory diseases and occupational exposure to wood dust. Part I. Fresh wood and mixed wood industry

Non-malignant respiratory diseases and occupational exposure to wood dust. Part II. Dry wood industry

Asthma, toxic alveolitis and respiratory symptoms among 1005 young farmers and 412 non farming rurals

Biomonitoring and work related symptoms among garbage handling workers

The shape of the maximum expiratory flow-volume curve reflects exposure in farming

Dermatoses among young farmers

Histamine responsiveness determined by partial flow-volume curves, atopy and smoking among 1005 young farmers

Change in airway inflammatory markers in Danish energy plant workers during a working week

A possible role of chitin in the pathogenesis of asthma and allergy

Can selectionexplain the protective effects of farming on asthma?

Plasma C3D levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings