Wyniki wyszukiwania

1

Cytochemical and functional evaluation of ACTH responsive isolated rat adrenocortical cells. The maintenance of sex differences

100%

Fichna P., Malendowicz L. K.

Folia Histochemica et Cytobiologica

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1987

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tom 25

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nr 1

2

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Badania morfometryczne i histochemiczne nad wpływem endoksanu na przysadkę mózgową i jądro szczura

100%

Mietkiewski K., Fichna P.

Zeszyty Problemowe Postępów Nauk Rolniczych

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1976

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tom 176

3

Badania toksykologiczne masy asfaltowej MAK. Cz.VI. Spostrzeżenia nad morfologią wybranych narządów

100%

Mlynarczyk W., Fichna P.

Bromatologia i Chemia Toksykologiczna

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1988

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tom 21

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nr 2

4

Association of chosen microsatellite markers on chromosomes 10, 11p and 14q with IDDM susceptibility in the population of midwestern Poland

100%

Jungerman M., Fichna P.

Journal of Applied Genetics

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1996

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tom 37

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nr 2

In search for new markers of insulin-dependent diabetes (IDDM) susceptibility we studied the CATT tetranucleotide repeat in intron 1 of tyrosine hydroxylase (TH) gene on chromosome lip, the CA repeat at T-cell receptor a chain (TCRA) locus on chromosome 14q and two CA repeats at D10S211 and D10S213 loci in the chromosome 10 region containing glutamic acid decarboxylase (GAD2) gene. Alleles at these microsatellite loci were identified in a population of diabetic children and unrelated healthy controls originating from Wielkopolska, a midwestern region of Poland. We found significant association of certain alleles at TH, TCRA and D10S211 loci with diabetes in the population under study. On the contrary, none of the alleles at D10S213 locus was associated with the disease. Our findings indicate that typing of microsatellite markers may represent useful additional tool for identifying individuals at high risk of developing IDDM. Regarding loci on chromosome 10 our data and data published by other authors may suggest the extistence of two separate regions of association with IDDM susceptibility on this chromosome.

5

Missense mutations and polymorphisms of the MC4R gene in Polish obese children and adolescents in relation to the relative body mass index

61%

Nowacka-Woszuk J., Cieslak J., Skowronska B., Majewska K. A., Stankiewicz W., Fichna P., Switonski M.

Journal of Applied Genetics

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2011

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tom 52

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nr 3

Extensive studies of the MC4R gene polymorphism showed that, among numerous variants, there are mutations responsible for monogenic obesity, as well as polymorphisms negatively correlated with the risk of obesity. In this report, we present the first studies of the whole coding sequence of the MC4R gene in 243 Polish obese children and adolescents (the mean relative body mass index [RBMI] was 163.6). In addition, 101 non-obese adults were also analyzed. Direct sequencing facilitated the identification of six missense (K73R, V103I, T112M, S127L, M215L, and I251L) and one silent (c.756 C > T) single-nucleotide polymorphisms (SNPs). Two non-synonymous polymorphisms (K73R and M215L) appeared to be novel and one was found in obese patients (M215L, one patient) and one in non-obese adults (K73R, one person). The overall frequency of non-synonymous variant carriers reached 4.1% and 6.9% in obese patients and non-obese adults, respectively. Only one obesity-associated variant (127L) was found in two obese patients (0.82%) and in two non-obese adults (1.98%). The obesity-protecting variants (103I and 251L) appeared to be the most common in both groups: 3.3% and 4.0%, respectively. It was also observed that the RBMI in obese children and adolescents carrying the minor variants did not differ significantly from the non-carriers; however, the expected trends for the associated and protecting variants were observed. We conclude that the contribution of the MC4R gene variants to the pathogenesis of obesity in Polish children and adolescents is low.

6

Polymorphisms of the toll-like receptor-3 gene in autoimmune adrenal failure and type 1 diabetes in Polish patients

61%

Fichna M., Zurawek M., Fichna P., Januszkiewicz-Lewandowska D., Ruchala M., Nowak J.

Archivum Immunologiae et Therapiae Experimentalis

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2016

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tom 64

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nr 1

7

Increased serum osteoprotegerin in patients with primary adrenal insufficiency receiving conventional hydrocortisone substitution

61%

Fichna M., Zurawek M., Fichna P., Gryczynska M., Nowak J., Ruchala M.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 6

8

MAVS is not a likely susceptibility locus for Addison’s disease and type 1 diabetes

51%

Zurawek M., Fichna M., Kazimierska M., Fichna P., Dzikiewicz-Krawczyk A., Przybylski G., Ruchala M., Nowak J.

Archivum Immunologiae et Therapiae Experimentalis

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2017

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tom 65

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nr 3

9

Wpływ ciśnienia tętniczego na uszkodzenie nerek u dzieci z cukrzycą typu 1

51%

Soltysiak J., Skowronska B., Fichna P., Silska M., Blumczynski A., Stankiewicz W., Lewandowska-Stachowiak M., Zachwieja J.

Medycyna Ogólna i Nauki o Zdrowiu

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2013

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tom 19(48)

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nr 1

Ograniczanie wyników

Cytochemical and functional evaluation of ACTH responsive isolated rat adrenocortical cells. The maintenance of sex differences

Badania morfometryczne i histochemiczne nad wpływem endoksanu na przysadkę mózgową i jądro szczura

Badania toksykologiczne masy asfaltowej MAK. Cz.VI. Spostrzeżenia nad morfologią wybranych narządów

Association of chosen microsatellite markers on chromosomes 10, 11p and 14q with IDDM susceptibility in the population of midwestern Poland

Missense mutations and polymorphisms of the MC4R gene in Polish obese children and adolescents in relation to the relative body mass index

Polymorphisms of the toll-like receptor-3 gene in autoimmune adrenal failure and type 1 diabetes in Polish patients

Increased serum osteoprotegerin in patients with primary adrenal insufficiency receiving conventional hydrocortisone substitution

MAVS is not a likely susceptibility locus for Addison’s disease and type 1 diabetes

Wpływ ciśnienia tętniczego na uszkodzenie nerek u dzieci z cukrzycą typu 1