The cytochrome P-450 dependent monooxygenase system is responsible for metabolism of exo- and endogenous compounds. It is induced or inhibited by many factors, including hormones. The effects of hormones on this system depend on the dose, manner and route of administration. The aim of this study was to test a controlled long-acting system of estradiol-progesterone release from a biodegradable copolymer and to evaluate the influence of the copolymer alone, or the copolymer with estradiol or progesterone on the hepatic enzymatic system responsible for biotransformation of xenobiotics. We have shown that the copolymer slightly affects the activity of the cytrochrome P-450 - dependent mixed oxygenase system (MFO), but not the desaturase system. Estradiol and progesterone modified the MFO activity in a typical manner.
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