Introduction: Migraine is a known risk factor for ischemic stroke. Recent studies have shown endothelial dysfunction in migraine patients. The aim of this study was to examine the levels of circulating Vascular Endothelial Growth Factor (VEGF) during interictal period. Material and methods: We included in the study 52 migraineurs (aged 37.9 ± 9.6 years). All patients satisfi ed criteria of IHS for the diagnosis of migraine. The control group was represented by 34 healthy subjects (aged 28.9 ±7.0 years). Serum VEGF, Macrophage Infl ammatory Protein-1 (MIP-1) and tumor necrosis factor (TNF) were analyze by means of ELISA. Results: The level of circulating VEGF was decreased (<0.05) during interictal period of migraine patients (281.53 ± 180.37 pg/ml) comparing to controls (441.80 ± 295.93 pg/ml). There were no differences (P>0.05) between TNF concentration in migraineurs and controls (median, min.ñmax.: 2.04; 0.49ñ18.6 and 2.14; 0.49ñ8.97, respectively). Similarly, serum MIP-1 did not showed differences (P>0.05) between both groups (migraineurs: 0.0; 0.0ñ285.25 and controls: 0.0; 0.0ñ333.54 pg/ml). Serum VEGF correlated with MIP-1 (rS=0.7684, P<0.05) and TNF level (rS=0.4791, P<0.05). Conclusion: Migraineurs have decreased serum VEGF concentration, which may be related endothelial dysfunction and responsible for increased risk of stroke. Both TNF and MIP may be involved in regulatory processes of VEGF production.
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