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Evaluation of the developmental toxicity of Ascaris pepsin inhibitor in mice

100%

Blaszkowska J.

Wiadomości Parazytologiczne. Suplement

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2007

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tom 53

2

The effect of alpha-chymotrypsin inhibitor from Ascaris lumbricoides suum on chick embryos

100%

Blaszkowska J.

Wiadomości Parazytologiczne

|

1998

|

tom 44

|

nr 1

63-71

It has been found that alpha-chymotrypsin inhibitor isolated from Ascaris lumbricoides suum acts embryotoxically on the Leghorn chicken embryo. An increase in embryo mortality with increasing dose of the inhibitor has been observed after its administration into the yolk sac on day 4, 8 or 13 of incubation. There is a linear interrelationship between the logarithm of the dose of alpha-chymotrypsin inhibitor and the mortality of chickens. The LD50 values for alpha-chymotrypsin inhibitor increased for injections performed at later stages of embryo development. A significant decrease of mean mass of chicks injected with alpha-chymotrypsin inhibitor in comparison with control groups was observed. There was a more frequent occurrence of developmental abnormalities and pathological changes in groups of hatched chicks which received the Ascaris inhibitor.

3

Spermatogenesis and mutagenicity of Ascaris chymotrypsin inhibitor in mice

100%

Blaszkowska J.

Wiadomości Parazytologiczne. Suplement

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2007

|

tom 53

4

XXXIV Dzien Kliniczny Parazytologii Lekarskiej - Wybrane aspekty terapii chorob pasozytniczych i grzybic

100%

Blaszkowska J.

Wiadomości Parazytologiczne

|

1997

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tom 43

|

nr 1

125-129

5

Comparison of the effect of Ascaris trypsin inhibitor in various periods of mouse pregnancy

100%

Blaszkowska J.

Wiadomości Parazytologiczne

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2001

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tom 47

|

nr 4

Trypsin inhibitor isolated from Ascaris suum and injected into pregnant BALB/c mice (five times, in doses: 300 or 400 mg/kg/day) in various periods of pregnancy (early and late organogenesis) disturbed the development of fetuses. The nature and intensity of prenatal disturbances are determined by the inhibitor dose and time of injection. It has been found that administration of the inhibitor from 5-th until 9-th day of gestation did not delay or prevent implantation, but caused a high rate of- intrauterine deaths and also specific congenital malformations (exnencephaly and hydrocephalus). Additionally, other types of defects were noted in fetuses after injection of the inhibitor between 8-th and 12-th day of pregnancy (cleft palate, fusion of ribs). Independent of the time of injection during gestation the inhibitor exhibited embriotoxic effects (e.g. decreased the number of live fetuses per litter and mean fetal weight).

6

Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum

100%

Blaszkowska J.

Wiadomości Parazytologiczne

|

2002

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tom 48

|

nr 1

It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.

7

Disturbances of mouse pregnancy after injection of Ascaris trypsin inhibitor during early organogenesis

100%

Blaszkowska J.

Zoologica Poloniae

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1999

|

tom 44

|

nr 1-4

8

Preliminary evaluation of maternotoxic effect of Ascaris extract in mice

100%

Blaszkowska J.

Wiadomości Parazytologiczne

|

2003

|

tom 49

|

nr 2

Administration intraperitoneally of the Ascaris suum extract - ASE-(0.6-1.4 g of Ascaris proteins/kg/day) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. lt has been found that injections of higher doses of ASE to pregnant mice caused the symptoms manifesting maternal toxicity (decreased body weight gain /p < 0.001/ as compared to control, intrauterine resorption of litter, vaginal hemorrhages, female mortality and altered behaviour). There is a linear interrelationship between the logarithm of the dose of ASE and mortality of pregnant mice. The DL₅₀ value of Ascaris proteins for pregnant mice was 1.02 g/kg/day (confidence interval 0.97-1.07 g/kg/day). ASE exerted embryotoxic effects: significantly decreased the number of surviving fetuses per litter and the mean body weight of fetuses, increased the number of fetal resorptions.

9

Effect of Ascaris trypsin inhibitor on fetal development of mice

100%

Blaszkowska J.

Wiadomości Parazytologiczne

|

2005

|

tom 51

|

nr 2

In this study, maternal toxicity and developmental effects of exposure to Ascaris trypsin inhibitor were evaluated in mice. Pregnant BALB/c females were injected intraperitoneally by Ascaris inhibitor /AIT/ at 200, 300, and 400 mg/kg body weight/day, on days 12 to 15 of gestation (stage of fetal development). At day 19 of pregnancy, uterine contents were inspected for implantation sites, early resorptions (moles), living fetuses and dead fetuses. The living fetuses were weighed and examined for external, internal and skeletal abnormalities. The results showed that AIT induced maternal toxicity, evidenced by maternal deaths, abortions, bleeding from uterus and reduced body weight gain as compared to control (p <0.01). There were no differences between the control group and the rest of all groups investigated for total implantation sites and early resorptions. Fetotoxicity was observed as shown by the decrease in the number of living fetuses and mean fetal weight, a high rate of intrauterine fetal deaths, delayed skeletal ossification, occurrence of pathological changes of fetal organs and tissues. Only one type of congenital malformations (hydronephrosis) was noted in fetuses after injection of higher doses of AIT.

10

Effect of Ascaris chymotripsin inhibitor on fetal development of mice

100%

Blaszkowska J.

Wiadomości Parazytologiczne

|

2004

|

tom 50

|

nr 3

11

Disturbances of mouse pregnancy after injection of Ascaris homogenate during early organogenesis

100%

Blaszkowska J.

Wiadomości Parazytologiczne

|

2000

|

tom 46

|

nr 3

Administration of the Ascaris tegumental homogenate (0.6-1.2 g of Ascaris proteins/kg/day) at a early stage of organogenesis (5-9 days of pregnancy) had a harmful effect upon the developing mouse fetuses. It has been found that injection of the homogenate did not delay or prevent implantation, but causes a high rate of intrauterine deaths. The Ascaris homogenate significantly decreased the number of live fetuses per litter, increased the frequency of litter resorption, produced a delay in bone formation and induced pathological changes of fetal organs and tissues. The congenital malformations were noted in fetuses after injection of higher doses of Ascaris homogenate (exencephaly, craniomeningocele and intemal hydrocephalus). No malformations were noted in control groups and after injection of minimum dose of the homogenate. The symptoms that occurred after administration of the tegumental homogenate to pregnant mice included: decreased body weight gain (p<0.001) as compared to controls, vaginal hemorrhage, intrauterine resorption of litter and mortality. These signs suggest that the Ascaris homogenate causes matemal toxicity.

12

The effect of alpha-chymotrypsin inhibitor from Ascaris lumbricoides suum on chick embryos

100%

Blaszkowska J.

Wiadomości Parazytologiczne

|

1998

|

tom 44

|

nr 1

It has been found that alpha-chymotrypsin inhibitor isolated from Ascaris lumbricoides suum acts embryotoxically on the Leghorn chicken embryo. An increase in embryo mortality with increasing dose of the inhibitor has been observed after its administration into the yolk sac on day 4, 8 or 13 of incubation. There is a linear interrelationship between the logarithm of the dose of alpha-chymotrypsin inhibitor and the mortality of chickens. The LD50 values foralpha-chymotrypsin inhibitor increased for injections performed at later stages of embryo development. A significant decrease of mean mass of chicks injected with alpha-chymotrypsin inhibitor in comparison with control groups was observed. There was a more frequent occurrence of developmental abnormalities and pathological changes in groups of hatched chicks which received the Ascaris inhibitor.

13

Embryotoxic and teratogenic action of trypsin inhibitor of Ascaris lumbricoides in mice

100%

Blaszkowska J.

Acta Parasitologica

|

1998

|

tom 43

|

nr 2

Trypsin inhibitor isolated from Ascaris lumbricoides suis and injected into pregnant BALB/c mice disturbed prenatal development of mice fetuses. The nature and intensity of prenatal disturbances in development are determined by the trypsin inhibitor dose. The symptoms that occurred after administration of the highest doses of Ascaris trypsin inhibitor to pregnant mice included: decreased body weight gain (p<0.05) as compared to controls, bleeding from the uterus, abortions and mortality. All doses of trypsin inhibitor exhibited an embryotoxic effect. Trypsin inhibitor significantly decreased the number of fetuses per litter, increased the frequency of litter resorption, produced a delay in bone formation and included pathological changes. Teratogenic effects of trypsin inhibitor were apparent in fetuses after doses of 200-400 mg per kg. The most frequent developmental defects were: cleft palate, fusion of ribs and micrognathia. No defects were noted in control groups. The trypsin inhibitor from Ascaris is a substance of considerable biological activity, which may be important in the outcome of the host-parasite relationship. It may be also a parasite pathogenic factor.

14

Parasitic infection and disturbances of fertility in humans

100%

Blaszkowska J.

Wiadomości Parazytologiczne

|

1998

|

tom 44

|

nr 4

According to literature of the problem, the disturbances of reproductiveness of human in various parasitic infections are discussed. The mechanisms disturbing the proper functioning of the hosts's reproductive system are not sufficiently understood. They may remain in association not only with a direct or indirect effect of the parasite on the host's endocrinal glands and sexual organs, but also with the host's overall reaction to stress or toxic influences. Parasite's activity may lead to abortion or a significant decrease in fetal body weight. Embryo or fetus may be also damaged in an intrauterine infection.

15

Parasitic diseases and fungal infections - their increasing importance in medicine

63%

Blaszkowska J., Wojcik A.

Wiadomości Parazytologiczne

|

2011

|

tom 57

|

nr 4

16

Current problems concerning parasitology and mycology with regard to diseases of the skin and its appendages

63%

Blaszkowska J., Wojcik A.

Annals of Parasitology

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2012

|

tom 58

|

nr 3

Current issues concerning Parasitology and Mycology with regard to diseases of the skin and its appendages are presented. Aspects of diagnostics, clinical picture and therapy of skin and nail mycoses, as well as difficulties in the diagnosis and treatment of both native parasitoses (toxoplasmosis) and imported human tropical parasitoses (malaria, filariosis) have been emphasised. The clinical importance of environmental mould fungi in nosocomial infections and fungal meningitis, as well as selected properties of fungi isolated from patients with head and neck neoplasms treated by radiotherapy are discussed. Other mycological topics include the characteristics of newlysynthesized thiosemicarbazides and thiadiazoles as potential drugs against toxoplasmosis and their biological activity against Toxoplasma gondii tachyzoites, selected molecular mechanisms of resistance to azoles, Candida albicans strains and a new tool (barcoding DNA) for describing the biodiversity of potential allergenic molds. The importance of environmental factors in pathogenesis of mycoses and parasitoses is noted. The characteristics of pathogenic fungi isolated from natural ponds in Bialystok and potentially pathogenic yeast-like fungi isolated from children’s recreation areas in Lodz are presented. The ongoing problem of anthropozoonoses is considered, as are the roles of stray cats and dogs in contaminating soil with the developing forms of intestinal parasites. The characteristics of the human microbiome, including population composition, activity and their importance in normal human physiology, are presented, as are the major goals of the Human Microbiome Project initiated by National Institutes of Health (NIH).

17

Prevention of transmission of potentially pathogenic fungi from the leech H. verbana used in hirudotherapy

63%

Blaszkowska J., Litwinowicz A.

Annals of Parasitology

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2016

|

tom 62

|

nr Suppl.

18

Parasitoses and mycoses - still current public health hazards

63%

Wojcik A., Blaszkowska J.

Annals of Parasitology

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2013

|

tom 59

|

nr 4

19

Parasites and fungi as risk factors for human and animal health

63%

Goralska K., Blaszkowska J.

Annals of Parasitology

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2015

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tom 61

|

nr 4

Recent literature data suggests that parasitic and fungal diseases, which pose a threat to both human and animal health, remain a clinical, diagnostic and therapeutic problem. Attention is increasingly paid to the role played by natural microbiota in maintaining homeostasis in humans. A particular emphasis is placed on the possibility of manipulating the human microbiota (permanent, transient, pathogenic) and macrobiota (e.g., Trichuris suis) to support the treatment of selected diseases such as Crohn’s disease, obesity, diabetes and cancer. Emphasis is placed on important medical species whose infections not only impair health but can also be life threatening, such as Plasmodium falciparum, Echinococcus multilocularis and Baylisascaris procyonis, which expand into areas which have so far been uninhabited. This article also presents the epidemiology, diagnosis and treatment of opportunistic parasitoses imported from the tropics, which spread across large groups of people through human-to-human transmission (Enterobius vermicularis, Sarcoptes scabiei). It also discusses the problem of environmentally-conditioned parasitoses, particularly their etiological factors associated with food contaminated with invasive forms (Trichinella sp., Toxoplasma gondii). The analysis also concerns the presence of developmental forms of geohelminths (Toxocara sp.) and ectoparasites (ticks), which are vectors of serious human diseases (Lyme borreliosis, anaplasmosis, babesiosis), in the environment. Mycological topics contains rare cases of mycoses environmentally conditioned (CNS aspergillosis) and transmissions of these pathogens in a population of hospitalized individuals, as well as seeking new methods used to treat mycoses.

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48. Dzien Kliniczny Parazytologii Lekarskiej: Rezerwuary pasozytow i grzybow chorobotworczych w populacji czlowieka i srodowisku

63%

Blaszkowska J., Wojcik A.

Wiadomości Parazytologiczne

|

2009

|

tom 55

|

nr 3

275-284

Ograniczanie wyników

Evaluation of the developmental toxicity of Ascaris pepsin inhibitor in mice

The effect of alpha-chymotrypsin inhibitor from Ascaris lumbricoides suum on chick embryos

Spermatogenesis and mutagenicity of Ascaris chymotrypsin inhibitor in mice

XXXIV Dzien Kliniczny Parazytologii Lekarskiej - Wybrane aspekty terapii chorob pasozytniczych i grzybic

Comparison of the effect of Ascaris trypsin inhibitor in various periods of mouse pregnancy

Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum

Disturbances of mouse pregnancy after injection of Ascaris trypsin inhibitor during early organogenesis

Preliminary evaluation of maternotoxic effect of Ascaris extract in mice

Effect of Ascaris trypsin inhibitor on fetal development of mice

Effect of Ascaris chymotripsin inhibitor on fetal development of mice

Disturbances of mouse pregnancy after injection of Ascaris homogenate during early organogenesis

The effect of alpha-chymotrypsin inhibitor from Ascaris lumbricoides suum on chick embryos

Embryotoxic and teratogenic action of trypsin inhibitor of Ascaris lumbricoides in mice

Parasitic infection and disturbances of fertility in humans

Parasitic diseases and fungal infections - their increasing importance in medicine

Current problems concerning parasitology and mycology with regard to diseases of the skin and its appendages

Prevention of transmission of potentially pathogenic fungi from the leech H. verbana used in hirudotherapy

Parasitoses and mycoses - still current public health hazards

Parasites and fungi as risk factors for human and animal health

48. Dzien Kliniczny Parazytologii Lekarskiej: Rezerwuary pasozytow i grzybow chorobotworczych w populacji czlowieka i srodowisku