Wyniki wyszukiwania

1

Neurohormones: oxytocin, vasopressin and related peptides - structure, genes, receptors, and evolution

100%

Kochman K.

Journal of Animal and Feed Sciences

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2013

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tom 22

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nr 4

Oxytocin (OT) and vasopressin (VP), and all related hormones, consist of nine amino acids with cysteine residues in positions 1 and 6 that form a six-amino acid cyclic part, and of a C-terminal glycine in α-amidated form. These neuropeptides are classified into oxytocin and vasopressin families based on the amino acid residue at position 8. OT-like and VP-like peptides are present in every vertebrate species. These peptides are a very ancient family of hormones having representatives in diverse species of invertebrates. Invertebrates have either a vasopressin-family peptide or an oxytocin-family peptide, whereas bony fishes, the ancestors of land vertebrates, have both isotocin and vasotocin. Presently, two evolutionary structural lineages have been proposed: an isotocin-mesotocin-OT line, associated with reproductive functions, and a vasotocin-VP line participating in water homeostasis. The ancestral gene encoding the precursor protein has been present in the animal genome for a period exceeding 500 million years of evolution. The exceptionally high stability of this structure of nine-amino acid peptides during the entire process of evolution suggests very powerful selective pressure, possibly by evolution together with respective receptors and specific processing enzymes. A novel gene with a distinct function and expression appeared during evolution through duplication of an ancestral gene. The synteny and order of genes in the neurohypophysial hormone gene locus are conserved in the lamprey, elephant shark, coelacanth, and tetrapods, but disrupted in teleost fishes presumably due to the rearrangements facilitated by a whole-genome duplication event in the teleost fish ancestor.

2

Kluczowa rola kwasów tłuszczowych omega-3 i omega-6 w biologii człowieka; predykcyjna teoria ewolucji Crawforda

100%

Kochman K.

Postępy Biologii Komórki

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2012

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tom 39

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nr 2

3

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

A brief overview of the process of the elucidation of GnRH structure (1971)

100%

Kochman K.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2012

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tom 93

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nr 4

4

Biosynteza, gromadzenie, uwalnianie i mechanizm działania GnRH

100%

Kochman K.

Zeszyty Problemowe Postępów Nauk Rolniczych

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1987

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tom 339

5

Evolution of gonadotropin-releasing hormone (GnRH) structure and its receptor

100%

Kochman K.

Journal of Animal and Feed Sciences

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2012

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tom 21

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nr 1

It is evident now that the gonadotropin-releasing hormone (GnRH) structure was already in existence very early in the evolution of animals and was co-opted in diverse ways to regulate reproduction. During 600 million years of animal evolution, the N and C termini of GnRH have been conserved as functional domains for binding and activating cognate receptors to accomplish its functions. About 400 millions years ago, a single substitution of the chiral amino acid in position 6 of GnRH in jawless fish by the achiral glycine facilitated a type II’ β-turn conformation of GnRH to allow spatially close interaction of functional domains of GnRH with receptors, in contrast to the interaction of more extended GnRH structures with their cognate receptors in earlier-evolved species. GnRH II was preconfigured to this conformation through intramolecular interactions, which accounts for its high binding affinity and total conservation of primary structure over 400 million years of evolution. It is very surprising and fascinating that the coordinated evolutionary selection of amino acids participating in binding GnRH has resulted in such perfection, that no substitution with a natural amino acid in any position improves binding potency.

6

Wpływ witaminy B6 na cykl rujowy szczurzycy

63%

Radzikowka M., Kochman K.

Zeszyty Problemowe Postępów Nauk Rolniczych

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1984

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tom 309

7

Involvement of copper in female reproduction

63%

Michaluk A., Kochman K.

Reproductive Biology

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2007

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tom 07

|

nr 3

8

Badania nad oczyszczaniem czynników podwzgórzowych, mających zdolność uwalniania hormonów gonadotropowych z przysadki

63%

Kochman K., Domanski E.

Acta Physiologica Polonica

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1969

|

tom 20

|

nr 4

9

Co nowego w sprawie OSN?

63%

Kochman K., Nagrabska J.

Poradnik Gospodarski

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2008

|

nr 11

4-5

10

The necessity of adequate nutrition with diets containing omega-3 and omega-6 fatty acids for proper brain development, function and delayed aging: Review

63%

Kochman K., Czauderna M.

Journal of Animal and Feed Sciences

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2010

|

tom 19

|

nr 4

11

Investigations on the action of hypothalamic substances in the secretion and release of gonadotropins

63%

Domanski E., Kochman K.

Acta Biologiae Experimentalis

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1967

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tom 27

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nr 3

12

Modulacja in vivo uwalniania gonadotropin oraz ekspresji genow dla ich podjednostek w przednim placie przysadki.

63%

Gajewska A., Kochman K.

Działalność Naukowa PAN. Wybrane Zagadnienia

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2002

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tom 13

97-99

13

Biosynthesis of gonadotropins in vivo

63%

Kochman K., Gajewska A.

Acta Neurobiologiae Experimentalis

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1996

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tom 56

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nr 3

14

Biosynthesis of the luteinizing hormone releasing hormone ( LH-RH) in the rat hypothalamus

51%

Kochman K., Kochman H., Domanski E.

Acta Physiologica Polonica

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1977

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tom 28

|

nr 4

15

Isolation of granules and vesicles rich in LH-RH and cetecholamines from the hypothalamus of female rabbit

51%

Ostrowska A., Luciani A., Kochman K.

Acta Physiologica Polonica

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1979

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tom 30

|

nr 1

16

DNA dependent - RNA polymerase activity in the chicken liver and breast muscle after protein restriction

51%

Kochman K., Kedzierska I., Kochman I.

Journal of Animal and Feed Sciences

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1993

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tom 02

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nr 3

137-145

17

Sezonowe reakcje w reakcji królików na doprzysadkowe wprowadzanie czynnika wyzwalającego sekrecję hormonu lutenizującego

51%

Domanski E., Kochman K., Przekop F.

Acta Physiologica Polonica

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1966

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tom 17

|

nr 4

18

GnRH receptors in hypophysis of sexually mature female carp [Cyprinus carpio L.] in spawning season

51%

Bieniarz K., Kochman K., Koldras M., Kochman H.

Polskie Archiwum Hydrobiologii

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2000

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tom 47

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nr 2

19

Prof. dr hab. Bernard Barcikowski [1936-2003]

51%

Przekop F., Kochman K.

Medycyna Weterynaryjna

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2003

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tom 59

|

nr 06

552

20

Effect of 4-MeSer-GnRH on the release and synthesis of gonadotropins in the female rat in vivo

45%

Kochman K., Gajewska A., Kochman H., Lerrant Y., Counis R.

Journal of Animal and Feed Sciences

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1997

|

tom 06

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nr 4

549-558

Ograniczanie wyników

Neurohormones: oxytocin, vasopressin and related peptides - structure, genes, receptors, and evolution

Kluczowa rola kwasów tłuszczowych omega-3 i omega-6 w biologii człowieka; predykcyjna teoria ewolucji Crawforda

A brief overview of the process of the elucidation of GnRH structure (1971)

Biosynteza, gromadzenie, uwalnianie i mechanizm działania GnRH

Evolution of gonadotropin-releasing hormone (GnRH) structure and its receptor

Wpływ witaminy B6 na cykl rujowy szczurzycy

Involvement of copper in female reproduction

Badania nad oczyszczaniem czynników podwzgórzowych, mających zdolność uwalniania hormonów gonadotropowych z przysadki

Co nowego w sprawie OSN?

The necessity of adequate nutrition with diets containing omega-3 and omega-6 fatty acids for proper brain development, function and delayed aging: Review

Investigations on the action of hypothalamic substances in the secretion and release of gonadotropins

Modulacja in vivo uwalniania gonadotropin oraz ekspresji genow dla ich podjednostek w przednim placie przysadki.

Biosynthesis of gonadotropins in vivo

Biosynthesis of the luteinizing hormone releasing hormone ( LH-RH) in the rat hypothalamus

Isolation of granules and vesicles rich in LH-RH and cetecholamines from the hypothalamus of female rabbit

DNA dependent - RNA polymerase activity in the chicken liver and breast muscle after protein restriction

Sezonowe reakcje w reakcji królików na doprzysadkowe wprowadzanie czynnika wyzwalającego sekrecję hormonu lutenizującego

GnRH receptors in hypophysis of sexually mature female carp [Cyprinus carpio L.] in spawning season

Prof. dr hab. Bernard Barcikowski [1936-2003]

Effect of 4-MeSer-GnRH on the release and synthesis of gonadotropins in the female rat in vivo