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In vitro effects of fipronil on neuronal excitability in mammalian and molluscan nervous systems

100%

Varro P., Gyori J., Vilagi I.

Annals of Agricultural and Environmental Medicine

2009

tom 16

nr 1

71-77

Comparative analysis of epileptiform activity developed in three in vitro models of epilepsy

100%

Vilagi I., Doczi J., Tarnawa I., Banczerowski-Pelyhe I.

Acta Neurobiologiae Experimentalis

1997

tom 57

nr 5

Effect of pesticides kynurenic acid production in rat brain slices

64%

Zielinska E., Kocki T., Saran T., Borbely S., Kuc D., Vilagi I., Urbanska E. M., Turski W. A.

Annals of Agricultural and Environmental Medicine

2005

tom 12

nr 2

177-179

Kynurenic acid (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive glycine allosteric site of the N-methyl-D-aspartate (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor. Animal studies showed that it possesses anticonvulsant and neuroprotective properties. Its involvement in the pathophysiology of various brain disorders was suggested. In this study, the effect of pesticides on KYNA production in brain cortical slices was investigated. Pyrethroids, deltamethrin and fenpropathrin significantly lowered KYNA production. Methomyl, bensultap, fipronil, diquat and MCPA were ineffective in this regard. In view of this data, the inhibition of KYNA synthesis appear to merit further investigation as a potential factor contributing to the toxicology of pyrethroids.

Ograniczanie wyników

2 Annals of Agricultural and Environmental Medicine

1 Acta Neurobiologiae Experimentalis

3 Vilagi I.

1 Banczerowski-Pelyhe I.

1 Borbely S.

1 Doczi J.

1 Gyori J.

1 Kocki T.

1 Kuc D.

1 Saran T.

1 Tarnawa I.

1 Turski W. A.

1 Urbanska E. M.

1 Varro P.

1 Zielinska E.

1 2009

1 2005

1 1997

Wyniki wyszukiwania

In vitro effects of fipronil on neuronal excitability in mammalian and molluscan nervous systems

Comparative analysis of epileptiform activity developed in three in vitro models of epilepsy

Effect of pesticides kynurenic acid production in rat brain slices