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1

Microscopic-electron examinations of the influence of the selected antibiotics on the secretory cells of the mammary gland

100%
Cegielski M.
Folia Histochemica et Cytobiologica
|
1986
|
tom 24
|
nr 4
2

Terapia komorkowa - nadzieja w leczeniu sciegien u koni

63%
Cegielski M., Kalisiak O.
Życie Weterynaryjne
|
2008
|
tom 83
|
nr 09
754-756
3
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Komórki macierzyste w leczeniu ścięgien u koni

63%
Kalisiak O., Cegielski M.
Życie Weterynaryjne
|
2013
|
tom 88
|
nr 02
4

Search for stem cells for pulmonary alveolar epithelium

51%
Cegielski M., Calkosinski I., Dziegiel P., Zabel M.
Bulletin of the Veterinary Institute in Puławy
|
2004
|
tom 48
|
nr 4
5

The search for stem cells of the epithelium in pulmonary alveoli

51%
Cegielski M., Calkosinski I., Dziegiel P., Zabel M.
Folia Morphologica
|
2004
|
tom 63
|
nr 2
In recent years significant progress has been witnessed in the identification of stem cells, which have now also been identified in the lungs. The aim of this was to induce post-pneumonia alveolar regeneration to facilitate the identification of stem cells. The studies were performed on Buffalo strain rats. Pneumonia was induced in the animals by a sub-pleural injection of carragenin. On days 4, 5 and 10 of the experiment both the control and experimental animals received intraperitoneal injections of bromodeoxyuridine (BrdU). Twenty-four hours after the last BrdU injection the rats were sacrificed and samples of the lungs were taken for examination. In order to detect proliferating cells in the paraffin sections, BrdU incorporation was detected with monoclonal antibodies. In pilot experiments BrdU incorporation was demonstrated in individual alveolar cells of variable distribution and of variable intensity in the colour reaction. The results have confirmed the existence of stem cells in pulmonary alveoli but their closer characterisation requires further studies with other techniques to detect pulmonary stem cells.
6

Wplyw jednorazowej dawki TCDD na poziom estrogenow i reprodukcje u szczurow

45%
Calkosinski I., Borodulin-Nadzieja L., Standa M., Wasilewska U., Cegielski M.
Medycyna Weterynaryjna
|
2003
|
tom 59
|
nr 06
536
7

Apoptotic changes in the myocardium in the course of experimentally-induced pleurisy

45%
Calkosinski I., Cegielski M., Dziegiel P., Skalik R., Majda J.
Folia Morphologica
|
2004
|
tom 63
|
nr 2
The secreted proinflammatory interleukins IL-1, IL-6 and TNF in the course of experimentally-induced pleurisy can be the cause of pathological changes in the ultrastructure of cardiac muscle and of apoptosis. The pleurisy was induced in rats by means of carrageenin. The scraps of cardiac muscle obtained during the inflammatory reaction in the pleura were analysed by means of an electron microscope. The scraps were also stained with the TUNEL method in order to find the apoptotic foci. It was proved by the experiment that the inflammatory process affected mitochondria in the cardiomyocytes, enhanced collagen fibre synthesis and contributed to the formation of apoptotic foci in the cardiac muscle.
8

Immunocytochemical identification of neoplastic cell clone in phase S of cell cycle in transplantable rat tumors

45%
Nowak M., Madej J. A., Dzimira S., Cegielski M., Calkosinski I.
Polish Journal of Veterinary Sciences
|
2004
|
tom 07
|
nr 3
Wistar and Buffalo rats of both sexes, aged 4 months, were divided into three groups: I which was given an intramuscular injection of 3 x 10 6 cells of Morris hepatoma (Buffalo males), II - subcutaneous injection of 3 x 10 4 cells of mammary gland carcinoma (Wistar females), III - intraperitoneal injection of 3 x 104 cells of Yoshid sarcoma (Wistar males). The animals were killed: in group I - 19, group II - 13 and in group III - 6 days after tumor transplantation. Twenty four hours before euthanasia the rats were given 5-brome-2'-deoxyuridine (BRd-U) at a dose of 50 mg/kg body mass. The control group consisted of animals with tumour. They were not treated with BRd-U. Im- munocytochemical reaction was performed on the sections of tumors, using monoclonal anti-BRd-U clone BU-33, Sigma. Computer measurements of tumor cells were carried out. There was a high similarity in morphological parameters between two kinds of cancer, and clear differences between them and Yoshid sarcoma. The main difference was noted in a twofold increase in the quantity of synthesised DNA in the nuclei of sarcoma cells. Immunocytochemical identification of tumor cells in phase S of the cell cycle with the use of monoclonal anti-BRd-U antibody is a precise and quick method of estimation of their proliferative potential.
9
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Influence of antlerogenic stem cells on the healing of lesions in the corneal epithelium and corneal stroma in rabbits

39%
Kielbowicz M., Kuropka P., Cegielski M., Kielbowicz Z., Trebacz P., Hebel M., Aleksiewicz R.
Polish Journal of Veterinary Sciences
|
2020
|
tom 23
|
nr 2
10

Wplyw 2,3,7,8-tetrachlorodibenzo-p-dioksyny [TCDD] na czynnosc i strukture jajnikow oraz jader potomstwa u szczurow

39%
Calkosinski I., Wasilewska U., Borodulin-Nadzieja L., Cegielski M., Dziegiel P., Standa M., Majda J.
Medycyna Weterynaryjna
|
2004
|
tom 60
|
nr 11
1218-1221
11

Search for stem cells in the growing antler stag [Cervus elaphus]

39%
Cegielski M., Calkosinski I., Dziegiel P., Gebarowski T., Podhorska-Okolow M., Skalik R., Zabel M.
Bulletin of the Veterinary Institute in Puławy
|
2006
|
tom 50
|
nr 2
12
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Evaluation of serum cytokine levels in recurrent airway obstruction

33%
Niedzwiedz A., Borowicz H., Kubiak K., Nicpon J., Skrzypczak P., Jaworski Z., Cegielski M., Nicpon J.
Polish Journal of Veterinary Sciences
|
2016
|
tom 19
|
nr 4
Recurrent airway obstruction (RAO) represents a serious health problem and is traditionally classified as an allergic disease, where contact with an antigen can induce clinical airway inflammation, bronchial hyper-responsiveness and reversible airway obstruction. Previous studies have demonstrated the presence of the Th2 response in the lungs of human patients with asthma and horses with heaves. These cells are involved in the production of cytokines which regulate the synthesis of immunoglobulins. 40 horses were evaluated: 30 horses with RAO and 10 healthy animals. The expression levels of interferon-alpha 1 (IFN-α1), interferon-gamma (IFN-γ), interleukin-1β, (IL-1β), IL-2, IL-4, IL-13 and tumor necrosis factor alpha (TNF-α) were measured in the serum obtained from control and RAO-susceptible horses during crisis. In all the patients, serum cytokine levels were detected. Serum median IL-13 and IFN-γ levels were significantly higher in RAO-affected horses than in the healthy group (p < 0.001). The serum median IFN-α1, IL-1β, IL-2, IL-4, and TNF-α levels were similar in both groups. These results indicate a low variability of the levels of cytokines and a high frequency of their detection in serum samples from horses with RAO. Immune mechanisms involved in equine RAO are more complex than those defined by a simple Th1/Th2 dichotomy.
13

Influence of inflammatory reaction on blood concentration of cholesterol and other biochemical values with regard to cardiac muscle damage in rats

33%
Calkosinski I., Skalik R., Borodulin-Nadzieja L., Wasilewska U., Janocha A., Cegielski M., Ponikowska B., Gozdzik A.
Bulletin of the Veterinary Institute in Puławy
|
2004
|
tom 48
|
nr 4
14

Expression of metallothionein in renal tubules of rats exposed to acute and endurance exercise

33%
Podhorska-Okolow M., Dziegiel P., Dolinska-Krajewska B., Dumanska M., Cegielski M., Jethon Z., Rossini K., Carraro U., Zabel M.
Folia Histochemica et Cytobiologica
|
2006
|
tom 44
|
nr 3
15

Long-term effects of subdural injections of an antlerogenic cell homogenate (ACH) in a porcine model of spinal cord injury (SCI)

27%
Wrzosek M., Plonek M., Nicpon J., Chelmonska-Soyta A., Podgorski P., Cegielski M., Gebarowski T., Mietelska-Porowska A., Wojda U., Gajewska-Wozniak O., Skup M.
Acta Neurobiologiae Experimentalis
|
2017
|
tom 77
|
nr Suppl.1
INTRODUCTION: The potential use of stem cells in spinal cord regeneration is widely discussed. Xenogenic implantation of antlerogenic stem cell homogenate (ACH) was reported to improve cartilage and cornea regeneration. AIM(S): A multilevel spinal cord reaction assessment to an ACH implantation in a spinal cord injury (SCI) porcine model was undertaken. METHOD(S): ACH (cell line MIC-1; 10×106 cells/ml) was obtained using sonification. Five groups were studied: A-sham, B-negative control, C–E with subdural ACH injection, applied immediately after SCI (C), and 1h (D) and 24 h (E) after SCI. Before (P0), directly after (P1), 2 weeks (P2) and 8 weeks (P3) after contusion, CBC and standard blood biochemistry, TP and CSF pleocytosis, UCHL-1, TNF‑alfa, MBP, IL‑8, IL‑6, IL‑1β in the serum and CSF were compared. The degree of SCI on MRI (1.5T, Philips, Ingenia) and MR-DTI parameters (FA, ADC) were also evaluated. Post-mortem histopathology and IHC labeling for an astroglial (GFAP) and microglial (IBA) reaction were performed. All of the above analyses were double-blind and randomized. RESULTS: The majority of the CSF changes were found only in the late postlesion period (P3). The lack of serum IL‑1β changes during the entire experiment in all animals, together with the HP and IHC findings, point to a lack of pro‑inflammatory reaction to the subdural ACH implantation. Decreased levels of cell degeneration markers (MBP, TNF alfa, IL-8) in the CSF of the animals where ACH was used suggest that it has potential neuroprotective activity. CONCLUSIONS: MR and MR-DTI results and a small astrocyte and microglial response in group C (subdural ACH implantation directly after the SCI), suggest a potential beneficial influence of ACH on the neuronal tissue at the injury site. However, due to the data inhomogeneity, a longer observation on a larger group of animals should be conducted. FINANCIAL SUPPORT: This study was conducted in a National Center for Research and Development project (UOD-DEM-1-352/001) .
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