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1

Wisfatyna - PBEF. Czynnik insulinomimetyczny

100%
Oclon E.
Weterynaria w Praktyce
|
2008
|
tom 05
|
nr 1
48-49
2

Oreksyny A i B

88%
Oclon E.
Weterynaria w Praktyce
|
2007
|
tom 04
|
nr 1
26-28
3

Selection of the most stable endogenous control genes for microrna quantitation in chicken ovarian follicles

63%
Oclon E., Hrabia A.
Annals of Animal Science
|
2020
|
tom 20
|
nr 1
4

Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

63%
Oclon E., Pietras M.
Journal of Animal and Feed Sciences
|
2011
|
tom 20
|
nr 1
It is known that centrally injected ghrelin is an anorexigenic peptide in chicken. Its activity is not mediated by NPY/AgRP - producing neurons but through the corticosterone releasing hormone (CRH) - expressing neurons in hypothalamus which activate the hypothalamo-pituitary-adrenal (HPA) axis inducing an increase in plasma corticosterone levels. However, controversial results of peripheral ghrelin effect on appetite have been reported. Thus, the influence of intraperitoneal-injected ghrelin on the activity of the HPA axis in Cobb broiler chickens was examined. In addition, the effect of glucocorticoids antagonist (RU486) on the ghrelin activity was also investigated. The intraperitoneal co-injection of CRH-receptor antagonist, astressin, partially attenuated ghrelin-induced anorexia and corticosterone release. Co-administration of RU486 significantly enhanced the inhibitory effect of ghrelin on feed intake in 7-day- old broiler chickens. These results indicate that the peripheral ghrelin - induced anorexia is caused by the stimulation of HPA axis in chickens.
5

Grelina-obestatyna - nowy mechanizm regulacji laknienia?

63%
Oclon E., Pietras M.
Medycyna Weterynaryjna
|
2007
|
tom 63
|
nr 10
1139-1141
Ghrelin and obestatin are encoded by the same gene and originate from posttranslational processing of the preproghrelin peptide. The activities of ghrelin and obestatin are different. The effects of obestatin on feeding behavior, body weight regulation are the opposite to those of ghrelin. Administration of ghrelin increases food intake, while, contrarily, the systemic and central administration of obestatin inhibits feeding. Ghrelin and obestatin interact with two distinct subtypes of G-protein-coupled receptor: GHS-R and GPR 39
6
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Ghrelina - peptydowy hormon zoladkowy

63%
Oclon E., Pietrac M.
Postępy Nauk Rolniczych
|
2006
|
tom 53
|
nr 2
3-14
7

Apoptotic responses to acute and chronic inflammation in the tissues of young pigs

51%
Zubel-Lojek J., Pierzchala-Koziec K., Oclon E., Latacz A.
Acta Biologica Cracoviensia. Series Zoologia
|
2013-2014
|
tom 55-56
8

Proinflammatory factors increased ghrelin synthesis and secretion in growing lambs

51%
Zubel J., Pierzchala-Koziec K., Oclon E., Fedorczak J.
Acta Biologica Cracoviensia. Series Zoologia
|
2009
|
tom 51
33-37
9

Hyperglycemia-induced changes in resistin gene expression in white adipose tissue in piglets

51%
Oclon E., Zubel-Lojek J., Latacz A., Pierzchala-Koziec K.
Annals of Animal Science
|
2015
|
tom 15
|
nr 3
10

Hyperglycemia-iInduced changes in rat hippocampal mTOR and opioid-like peptides

51%
Latacz A., Pierzchala-Koziec K., Zubel-Lojek J., Oclon E.
Acta Biologica Cracoviensia. Series Zoologia
|
2015
|
tom 57
11

Acute and chronic inflammation affects plasma insulin and glucagon levels in piglets

51%
Zubel-Lojek J., Oclon E., Latacz A., Pierzchala-Koziec K.
Acta Biologica Cracoviensia. Series Zoologia
|
2015
|
tom 57
12

Increased resistin expression and concentration in epicardial adipose tissue of mice with metabolic syndrome

51%
Oclon E., Koziec K., Zubel J., Fedorczak J.
Acta Biologica Cracoviensia. Series Zoologia
|
2009
|
tom 51
5-9
13

The effect of statin on the met-enkephalin-like peptides in the diabetic piglets striatum

51%
Pierzchala-Koziec K., Zubel J., Oclon E., Fedorczak J.
Acta Biologica Cracoviensia. Series Zoologia
|
2010
|
tom 52
14

Adipose tissue tumor necrosis factor-alpha and interleukin-6 response to glucocorticoid treatment during inflammation

51%
Zubel-Lojek J., Oclon E., Latacz A., Pierzchala-Koziec K.
Folia Biologica
|
2016
|
tom 64
|
nr 3
15

Fat resistin and adiponectin mRNA expression is modulated by glucocorticoids in mice

51%
Zubel J., Pierzchala-Koziec K., Oclon E., Latacz A.
Acta Biologica Cracoviensia. Series Zoologia
|
2012
|
tom 54
It is known that obesity is associated with a state of chronic low-level inflammation. Some data indicate that obesity- related stress could increase the hypothalamo-pituitary-adrenal axis activity. This leads to a rise in the plasma glucocorticoid level, which induces the development and differentiation of preadipocytes. Thus, the present study was performed to examine the effect of glucocorticoids on the expression of resistin and adiponectin mRNAs in adipose tissue during acute and chronic inflammation in mice. The results of the study showed an increase in the expression of resistin mRNA and a decrease in the expression of adiponectin mRNA during chronic inflammation (obese animals). Synthetic glucocorticoids changed the expression of both adipokines in a different manner according to the state of inflammation. To sum up, the action of glucocorticoids in adipose tissue depends on the immune system activity.
16

Corticotrophin releasing factor modulates the morphine effect on the mu, delta and kappa opioid receptor agonist binding in lamb hypothalamic-pituitary-adrenal axis

51%
Pierzchala-Koziec K., Zubel-Lojek J., Latacz A., Oclon E.
Prace Komisji Nauk Rolniczych, Leśnych i Weterynaryjnych. Polska Akademia Umiejętności
|
2015
|
tom 21
17

Effects of Lactobacillus rhamnosus on the growth performance, weight of organs and plasma lipid indices of broiler chickens

51%
Pietras M., Barowicz T., Oclon E.
Polish Journal of Natural Sciences. Supplement
|
2006
|
tom 03
483-490
18

mTOR pathway novel modulator of astrocyte activity

45%
Latacz A., Russell J. A., Oclon E., Zubel-Lojek J., Pierzchala-Koziec K.
Folia Biologica
|
2015
|
tom 63
|
nr 2
19

Emotional stress induces sex-specific sympatho-adrenomedullary responses in lambs

45%
Pierzchala-Koziec K., Zubel-Lojek J., Oclon E., Latacz A., Kepys B.
Acta Biologica Cracoviensia. Series Zoologia
|
2015
|
tom 57
20

Possible neural compenasatory mechanisms for the communication between the nervous and immune systems after cyclooxygenase inhibition

45%
Kobrzycka A., Wieczorek M., Zubel J., Oclon E., Hubner M.
Acta Neurobiologiae Experimentalis
|
2015
|
tom 75
|
nr Supl.
BACKGROUNDANDAIMS: The phenomenon of communication between the nervous and immune systems is commonly accepted. There were postulated several pathways for information exchange between these two systems, among them: neuronal with the vagus nerve, and enzymatic exercised through cyclooxygenases. The fact of biological compensation of many processes in our organisms is well known. In our project we hypothesized the existence of such phenomenon is situation of affected pathway for transferring of immune signal from the periphery to the brain after inhibition of cyclooxygenases. METHODS: To investigate the existence of these mechanisms, neurochemical changes occurring in the hypothalamus (the initial section of the stress axis – HPA) after intraperitoneal administration of LPS (10 mcg/animal) were analyzed. We studied the effect of long-term (10 days) administration of cyclooxygenases inhibitors on the neurochemical changes in the activity of the hypothalamus in response to LPS or saline ip administration. The rats were subcutaneously injected with selective cyclooxygenases inhibitors; Celecoxib (10 mg/kg) and SC-560 (3 mg/kg), respectively. RESULTS: Future HPLC analysis shown an increased activity of the noradrenergic and serotonergic systems within the hypothalamus. These data are comparable with those obtained after saline injections. CONCLUSIONS: These results suggest the presence of compensatory mechanisms responsible for the stimulation of the HPA axis after peripherally immune challenges. They also suggest that longterm intake of non-steroidal anti-inflammatory drugs may not affect, or in a very minor degree, the relationships between the immune and the nervous systems. Supported by NCN: UMO-2012/07/B/NZ4/00205.
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