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Rozpoznawanie ostrych porfirii wątrobowych

100%

Kostrzewska E., Gregor A.

Diagnostyka Laboratoryjna

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1984

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tom 20

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nr 4

2

Neonatal hypoxic-ischemic brain injury activates hippocampal stem/progenitor cells

81%

Gregor A., Kozlowska H., Zalewska T.

Acta Neurobiologiae Experimentalis

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2011

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tom 71

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nr S

Birth asphyxia remains a frequent cause of perinatal morbidity and mortality. During perinatal hypoxic-ischemic (HI) brain injury neuronal cells are damaged and lose their function or die. Recently, it has become clear that ischemic brain injury stimulates neural stem cell proliferation and differentiation in cerebral neurogenic areas – subventricular zone (SVZ) and dentate gyrus (DG) of the hippocampus frequently injured after the perinatal HI. There is a tremendous speculation, that the induction of these progenitors after injury may represent an endogenous mechanism for brain regeneration. To study the response of hippocampal progenitors to neonatal HI brain damage, we utilized an established model of HI induced in rats of postnatal day 7 (PND7). The left common carotid artery was ligated and then after 60 min of recovery, the animals were exposed to hypoxia (7.4% oxygen for 75 min). The hypoxic undamaged hemisphere served as control for developmental modification. In addition, age-matched sham-operated rats were also used as controls. At 4, 10, 14, and 21 days following hypoxia, pups were perfused transcardially with PBS followed by 4% PFA. To determine the proliferation profile animals were injected with BrdU (50 mg/ kg) at various days after HI and immunopositive cells were analyzed the next day. At 4 - 14 days after HI the presence of BrdUpositive cells was seen in both, ipsi- and contralateral hemispheres, with the greatest number of dividing cells in the ischemic side. Thereafter, cell proliferation appeared to be reduced. The labeling pattern revealed structure-dependent differences. At 4 days after the insult the highest density of cells incorporating BrdU was seen in hilus, whereas at longer survival time the majority of labeled cells were located in the DG. To confirm that the BrdU-positive cells represent dividing progenitors we used double staining: BrdU/Ki67, BrdU/PSA-NCAM and immature neuronal marker - DCX.

3

Regulation of neurogenesis by extracellular matrix and integrins

81%

Wojcik-Stanaszek L., Gregor A., Zalewska T.

Acta Neurobiologiae Experimentalis

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2011

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tom 71

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nr 1

Deciphering the factors that regulate human neural stem cells will greatly aid in their use as models of development and as therapeutic agents. The complex interactions of cells with extracellular matrix (ECM) proteins probably contribute to proper central nervous system development mediating processes which regulate proliferation and differentiation of neural stem/rogenitor cells. Many of these interactions involve transmembrane integrin receptors. Integrins cluster in specific cellmatrix adhesions to provide dynamic links between extracellular and intracellular environments by activation of numerous signal transduction pathways which may influence cell behaviour profoundly by influence on both gene expression and post- transcriptional signalling cascade. In this review we introduced and discussed a number of extracellular and intracellular factors engaged in the transduction of signals induced by cell adhesion to its environment, including matrix components, extracellular proteolytic enzymes, integrins and non-receptor tyrosine kinases.

4

Aktywność oksydazy koproporfirynogenu u chorych z podejrzeniem dziedzicznej koproporfirii

81%

Gregor A., Tarczynska-Nosal S., Stachurska H.

Diagnostyka Laboratoryjna i Wiadomości PTDL

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1997

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tom 33

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nr 2

5

Immunoelectron microscopic localization of monoclonal IgM antibodies in gammopathy with demeyelinative neuropathy

81%

Rippstein P. Atack D. Grepor A. L. B., Atack P., Gregor A.

Acta Neurobiologiae Experimentalis

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1992

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tom 52

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nr 3

6

Aktywność ferrochelatazy u chorych z erytropoetyczną protoporfirią i u członków ich rodzin

81%

Gregor A., Tarczynska-Nosal S., Szlendak U., Pietrzykowski K.

Diagnostyka Laboratoryjna

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2000

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tom 36

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nr 3

7

Próby jakościowe na zwiększoną ilość porfobilinogenu w moczu w diagnostyce ostrych porfirii wątrobowych

71%

Tarczynska-Nosal S., Gregor A., Ekiert M., Stachurska H., Kostrzewska E.

Diagnostyka Laboratoryjna

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1998

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tom 34

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nr 2

8

Badanie wplywu diargininianu hemu na poziom biopierwiastkow u pacjentow z ostra przerywana porfiria - AIP

61%

Graczyk A., Gregor A., Bulska E., Windyga J., Kasprzycka W., Karasinski J., Wasilewski R.

Journal of Elementology

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2010

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tom 15

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nr 3 Suppl.

33-34

9

Proba oceny zawartosci podstawowych biopierwiastkow i metali toksycznych u pacjentow chorych na rozne typy porfirii

61%

Graczyk A., Gregor A., Dlugaszek M., Lipnicka A., Szlendak U., Bianketti J.

Journal of Elementology

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2008

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tom 13

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nr 3 Suppl.

27-28

Ograniczanie wyników

Rozpoznawanie ostrych porfirii wątrobowych

Neonatal hypoxic-ischemic brain injury activates hippocampal stem/progenitor cells

Regulation of neurogenesis by extracellular matrix and integrins

Aktywność oksydazy koproporfirynogenu u chorych z podejrzeniem dziedzicznej koproporfirii

Immunoelectron microscopic localization of monoclonal IgM antibodies in gammopathy with demeyelinative neuropathy

Aktywność ferrochelatazy u chorych z erytropoetyczną protoporfirią i u członków ich rodzin

Próby jakościowe na zwiększoną ilość porfobilinogenu w moczu w diagnostyce ostrych porfirii wątrobowych

Badanie wplywu diargininianu hemu na poziom biopierwiastkow u pacjentow z ostra przerywana porfiria - AIP

Proba oceny zawartosci podstawowych biopierwiastkow i metali toksycznych u pacjentow chorych na rozne typy porfirii