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1

PUVA-induced lipoapoptosis in human lymphocytes: arachidonic acid and its photoproducts

100%
Zarebska Z., Zielinska J., Zhukov I., Maslinski W.
Acta Biochimica Polonica
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2003
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tom 50
|
nr Supplement 1
2

Naturalne komorki regulatorowe [CD4plusCD25plus]

100%
Chorazy-Massalska M., Kontny E., Maslinski W.
Postępy Biologii Komórki
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2006
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tom 33
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nr 1
71-80
3

Kontrola odpowiedzi immunologicznej przez naturalne komorki regulatorowe

100%
Chorazy-Massalska M., Kontny E., Maslinski W.
Postępy Biologii Komórki
|
2006
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tom 33
|
nr 4
771-789
4

Stimulation of the human neutrophil respiratory burst by IL-15

100%
Wojtecka-Lukasik E., Maslinski W., Maslinski S.
Journal of Physiology and Pharmacology. Supplement
|
1997
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tom 48
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nr 2
5
Content available remote

Enhanced expression of mineralocorticoid receptors in the heart after the myocardial infarct in rats

100%
Milik E., Szczepanska-Sadowska E., Maslinski W., Cudnoch-Jedrzejewska A.
Journal of Physiology and Pharmacology
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2007
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tom 58
|
nr 4
Increasing evidence suggests that enhanced stimulation of the heart and kidney by mineralocorticoids plays significant role in development of the post-infarct cardiac failure. Because increased synthesis of mineralocorticoid receptors (MR) is one of the putative factors determining pathogenic effects of mineralocorticoids we decided to determine whether the myocardial infarct results in an enhanced expression of MR mRNA and MR protein. To this end male Sprague-Dawley rats were subjected either to ligation of the left coronary artery or to sham surgery. After four weeks expressions of MR mRNA and MR protein were evaluated in both groups of rats in the left (LV) and right (RV) ventricle walls, and in the renal cortex and renal medulla by means of semiquantitative PCR and Western blotting methods. Coronary ligation resulted in the myocardial infarction encompassing 30.2% ± 1.9% (range 23-40%) of the left ventricle wall. In the infarcted rats expression of MR mRNA was significantly greater than in the sham-operated rats, both in the LV (P<0.02) and in the RV (P<0.005). In the left but not in the right ventricle increased MR mRNA expression was associated with significant increase in expression of MR protein (P<0.001). In the renal cortex and renal medulla MR mRNA and MR protein expression in the infarcted and the sham-operated rats did not differ. The study reveals that during the post-infarct state expression of MR mRNA is elevated in both cardiac ventricles while expression of MR mRNA protein is increased only in the left ventricle. The results suggest that the enhanced expression of mineralocorticoid receptors may contribute to enhanced effects of mineralocorticoids in the heart during the post-infarct state.
6

Apoptosis induced by membrane damage in human lymphocytes; effects of arachidonic acid and its photoproducts

100%
Zarebska Z., Zielinska J., Zhukov I., Maslinski W.
Acta Biochimica Polonica
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2005
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tom 52
|
nr 1
The effect of arachidonic acid (AA) combined with UVA irradiation was studied in a model system mimicking phototherapy PUVA (psoralen+UVA) ex vivo in vitro. The contribution of damage to the plasma membrane by PUVA was tested on human lymphocytes derived from healthy donors. The effect of arachidonic acid (AA) combined with UVA irradiation was compared with that of a psoralen photoadduct to AA added to the culture. The adduct, obtained photochemically and purified, was characterized by NMR and MS spectrometry as a cycloadduct of psoralen to the vinylene bond of the acid (AA<>PSO).  The reactions of cultured cells, manifested 20 h after treatment by changes in apoptosis and mitochondrial depolarization, were monitored by flow cytometry by tagging lymphocytes with appropriate fluorescent probes. Treatment of lymphocyte suspension within AA doses from 40 to 100 μM gradually induced a shift from Anx-V+ (single positive cells) to late apoptotic, Anx-V+PI+ (double positive cells) in a dose dependent manner. The adduct, AA<>PSO, induced apoptotic changes at a concentration 2–3 times higher than free AA. Combination of psoralen (1 μM ) or arachidonic acid (20–120 μM) with UVA irradiation (2–6 J/cm2) accelerated the plasma membrane changes in a synergic way. Preliminary studies indicated that changes in the transmembrane potential of mitochondria paralleled the apoptosis when cells were treated by AA alone.  Our findings showed that UVA radiation of lymphocytes in the presence of arachidonic acid, as in the presence of psoralen, enhanced apoptosis of cells in a synergic manner. Thus, PUVA-induced apoptosis may proceed in part by a still undefined signaling pathway(s) triggered in lymphocyte membranes.
7

The function of interleukin 17 in the pathogenesis of rheumatoid arthritis

100%
Paradowska A., Maslinski W., Grzybowska-Kowalczyk A., Lacki J.
Archivum Immunologiae et Therapiae Experimentalis
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2007
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tom 55
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nr 5
8
Content available remote

Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mREN2)27 and sprague dawley rats

88%
Gozdz A., Szczepanska-Sadowska E., Szczepanska K., Maslinski W., Luszczyk B.
Journal of Physiology and Pharmacology
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2002
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tom 53
|
nr 3
Vasopressin plays significant role in regulation of blood pressure by means of V1 and V2 receptors, however regulation of synthesis of these receptors in hypertension is only poorly recognized. The puropose of the present study was to compare expression of V1a, V1b and V2 vasopressin (R) mRNA in the renal cortex, renal medulla and the heart of hypertensive renin transgenic TGR(mRen2)27 rats (TGR) and of their parent normotensive Sprague Dawley (SD) strain. The study was performed on 12 weeks old TGR and SD rats. Competitive PCR method was used for quantitative analysis of V1a, V1b and V2 receptors mRNA in fragments of renal cortex, renal medulla and apex of the left ventricle of the heart. In both strains expression of V1aR and V2R mRNA was significantly greater in the renal medulla than in the renal cortex. In the renal medulla but not in the cortex expression of V1aR mRNA was significantly greater in TGR than in SD rats. V2R mRNA expression was similar in the renal cortex and renal medulla of both strains. V1aR mRNA was well expressed in the heart of SD and TGR rats, however there was no significant difference between these two strains. V2R mRNA was not present in the heart. V1b R mRNa could not be detected either in the kidney or in the heart. The results provide evidence for specific increase of expression of V1a receptors mRNA in the renal medulla of TGR rats.
9

Changes in MiRNA-5196 expression as a potential biomarker of anti-TNF-alpha therapy in rheumatoid arthritis and ankylosing spondylitis patients

64%
Ciechomska M., Bonek K., Merdas M., Zarecki P., Swierkot J., Gluszko P., Bogunia-Kubik K., Maslinski W.
Archivum Immunologiae et Therapiae Experimentalis
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2018
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tom 66
|
nr 5
10

Oxidative modification of type II collagen differentially affects its arthritogenic and tolerogenic capacity in experimental arthritis

64%
Marcinkiewicz J., Biedron R., Maresz K., Kwasny-Krochin B., Bobek M., Kontny E., Maslinski W., Chain B.
Archivum Immunologiae et Therapiae Experimentalis
|
2004
|
tom 52
|
nr 4
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