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1

Five – Membered nitroxyl derivatives enhance paclitaxel anticancer activity in human breast cancer cells

100%
Matczak K., Koceva-Chyla A.
Current Topics in Biophysics. Supplement
|
2016
|
tom 39
|
nr A: Posters
2

Interconnection between apoptosis and autophagy in human breast cancer cells treated with Pirolin and doxorubicin

100%
Matczak K., Koceva-Chyla A.
Current Topics in Biophysics. Supplement
|
2016
|
tom 39
|
nr A: Posters
3

Professor Wanda Leyko (1921–2015). A biographical note

100%
Bryszewska M., Koceva-Chyla A.
Current Topics in Biophysics
|
2016
|
tom 39
|
nr 1
4

Effect of doxorubicin on the rate of reduction of nitroxides in B14 cells

81%
Czepas J., Koceva-Chyla A., Gwozdzinski K., Jozwiak D.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
5

Encapsulated doxorubicin armed with gH625 peptide does not damage normal endothelial cells as free doxorubicin

81%
Matczak K., Durka K., Galdiero S., Koceva-Chyla A.
Current Topics in Biophysics. Supplement
|
2016
|
tom 39
|
nr A: Posters
6

The influence of Scutellaria baicalensis main flavonoids on the proapoptotic activity of anticancer drugs in cancer and normal human cells

81%
Bernasinska J., Antosik K., Luczak T., Koceva-Chyla A.
Current Topics in Biophysics. Supplement
|
2013
|
tom 36
|
nr 2A: Posters
7

Anticancer activity of novel ferrocenyl-flavone complexes

81%
Hikisz P., Bernasinska J., Kowalski K., Koceva-Chyla A.
Current Topics in Biophysics. Supplement
|
2013
|
tom 36
|
nr 2A: Posters
8

Evaluation of the oxidative properties of hybrid nanospheres in human breast cancer cells

81%
Lewarska P., Pieniazek A., Fahmi A., Koceva-Chyla A.
Current Topics in Biophysics. Supplement
|
2013
|
tom 36
|
nr 2A: Posters
9

Synergistic interactions of nitroxides and doxorubicin in the induction of apoptosis: the proapoptotic effect of pirolin and tempace in immortalized rodent fibroblasts

81%
Koceva-Chyla A., Gwozdzinski K., Skierski J., Jozwiak Z.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
10

Effect of pirolin and doxorubicin on mitochondrial membrane potential in MCF-7 and MDA-MB-231 breast cancer cells

71%
Durka K., Matczak K., Pieniazek A., Gwozdzinski K., Koceva-Chyla A.
Current Topics in Biophysics. Supplement
|
2013
|
tom 36
|
nr 2A: Posters
11

Interaction of nitroxides and mitoxantrone with the plasma of cardiomyocytes

71%
Koceva-Chyla A., Sokal A., Kania K., Gwozdzinski K., Jozwiak Z.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
12

Effect of piperidine nitroxides on ROS- production generated by doxorubicin in cardiomyocytes

71%
Koceva-Chyla A., Przygodzki T., Balcerczyk A., Gwozdzinski K., Jozwiak Z.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
13

Nitroxide as an antioxidant in the protection of heart tissue in doxorubicin treated rats

71%
Koceva-Chyla A., Gwozdzinski K., Kochman A., Stolarska A., Jozwiak Z.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
14

Effects of pyrroline and pyrrolidine nitroxides on lipid peroxidation in heart tissue of rats treated with doxorubicin

71%
Koceva-Chyla A., Gwozdzinski K., Kochman A., Stolarska A., Jozwiak Z.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 1
Protection from doxorubicin-induced lipid peroxidation in vivo by two pyrroline and pyrrolidine nitroxides, Pirolin, PL, and Pirolid, PD, was examined in the heart tissue of rats treated with this drug. The level of lipid peroxidation was estimated on the basis of MDA content. A considerable (threefold) increase in the MDA amount was found in heart homogenates from rats injected with doxorubicin, whereas no significant changes in MDA content compared to control were observed in cardiomyocytes treated with the nitroxides (Pirolin or Pirolid) only. Pirolin injected simultaneously with doxorubicin showed antioxidative effect and markedly attenuated lipid peroxidation in the heart tissue caused by this drug. In contrast to Pirolin, structurally related Pirolid was ineffective in the protection of heart myocytes from DOX-induced lipid peroxidation.
15

The nitroxides pirolin and pirolid protect the plasma membranes of rat cardiomyocytes against damage induced by anthracyclines

71%
Koceva-Chyla A., Sokal A., Kania K., Gwozdzinski K., Jozwiak Z.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 1
This study was performed to evaluate the protective effects of pyrroline and pyrrolidine nitroxides Pirolin, PL, and Pirolid, PD, on the plasma membranes of rat cardiomyocytes treated in vitro with anthracycline drugs aclarubicin (ACL) and doxorubicin (DOX). The influence of two concentrations of drugs (10 and 20 μM) and nitroxides (0.1 and 1 mM) as well as their combinations (a drug and a nitroxide) on membrane fluidity was investigated. The plasma membranes of cardiomyocytes were labelled with a hydrophobic fluorescence probe 12-AS and membrane fluidity was estimated on the basis of the fluorescence anisotropy of the probe. We found that aclarubicin and doxorubicin induced a significant dose-dependent decrease in membrane fluidity, whereas the nitroxides (PL and PD) caused its increase. Preincubation of cardiomyocytes with Pirolin entirely protected plasma membranes of these cells against damage caused by DOX. In the same conditions no protective effect of Pirolid was observed. What is more, Pirolid in combination with DOX caused fluidisation of the plasma membranes of cardiomyocytes. Both nitroxides at low concentration (0.1 mM) protected plasma membranes against rigidification induced by aclarubicin, while high concentration (1 mM) was ineffective and caused fluidisation of the plasma membranes of cardiomyocytes.
16

The nitroxides pirolin and pirolid protect the plasma membrane of rat cardiomiocytes against damage induced by anthracyclines

71%
Koceva-Chyla A., Sokal A., Kania K., Gwozdzinski K., Jozwiak Z.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
17

Insights into the in vitro mechanisms of anticancer activity of diruthenium-1

61%
Hikisz P., Matczak K., Suss-Fink G., Furrer J., Kowalski K., Koceva-Chyla A.
Current Topics in Biophysics. Supplement
|
2016
|
tom 39
|
nr A: Plenary lectures
18
Content available remote

Nitroxide pirolin reduces oxidative stress generated by doxorubicin and docetaxel in blood plasma of rats bearing mammary tumor

61%
Tabaczar S., Koceva-Chyla A., Czepas J., Pieniazek A., Piasecka-Zelga J., Gwozdzinski K.
Journal of Physiology and Pharmacology
|
2012
|
tom 63
|
nr 2
19
Content available remote

The effect of the nitroxide pirolin on oxidative stress induced by doxorubicin and taxanes in the rat brain

61%
Tabaczar S., Czepas J., Koceva-Chyla A., Kilanczyk E., Piasecka-Zelga J., Gwozdzinski K.
Journal of Physiology and Pharmacology
|
2017
|
tom 68
|
nr 2
20

Effect of adriamycin and gamma-radiation on cultured mammalian cells measured by flow cytometry

61%
Koceva-Chyla A., Distel L., Zaborowski A., Skierski J., Rozga B., Schussler H., Jozwiak Z.
Current Topics in Biophysics
|
1994
|
tom 18
|
nr 2
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