Wyniki wyszukiwania

1

Receptory wiazace pozne produkty glikacji.

100%

Stalinska K.

Postępy Biologii Komórki. Suplement

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2001

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tom 16

35-42

2

Glycated proteins as inducers of acute phase cytokines

72%

Guzdek A., Stalinska K.

Folia Histochemica et Cytobiologica

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1992

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tom 30

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nr 4

3

Effect of glycosaminoglycans accumulation on the non-oxidative sulfur metabolism in mouse model of Sanfilippo syndrome, type B

58%

Kaczor-Kaminska M., Kaminski K., Stalinska K., Feldman A.

Acta Biochimica Polonica

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2019

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tom 66

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nr 4

4

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Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants

58%

Stalinska K., Guzdek A., Rokicki M., Koj A.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 1

157-169

During the inflammatory response at least 2 transcription factors, NF-kB and AP-1, are involved in the altered profile of gene expression. We used human hepatoma (HepG2) and human umbilical vein endothelial cells (HUVEC) as a model system: NF-kB and AP-1 were activated by the proinflammatory cytokine IL-1 in the absence or presence of 21 selected plant extracts and the effect was evaluated by the electrophoretic mobility shift assay (EMSA). In both types of cells activation of NFkB by IL-1 was significantly inhibited by extracts from Scandix australis and Artemisia alba, whereas extracts from Amaranthus sp., Eryngium campestre, Thymus pulegioides and Reichardia picroides elicited cell-type dependent response. The IL-1-induced AP-1 activation was diminished by extracts from Scandix australis, Amaranthus sp. and Artemisia alba more potently in HUVEC, while extracts from Urospermum picroides and Scandix pecten-veneris in HepG2 cells. Inhibitory activities of plant extracts towards cytokine activated NF-kB and AP-1 depend to some extent on the order of addition of IL-1 and plant extract to the cell culture, but the mechanism of action of extract components is not clear: although plant polyphenols may participate they are unlikely to be the only mediators, and MAP kinases were found generally not involved in down-regulation of transcription factors activity by plant extracts.

5

Differential responses of hematopoietic and non-hematopoietic cells to anti-inflammatory cytokines: IL-4, IL-13 and IL-10

58%

Guzdek A., Stalinska K., Guzik K., Koj A.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 3

6

Regulation of vascular endothelial growth factor synthesis by doxycycline regulated overexpression of heme oxygenase-1

51%

Wegrzyn J., Staskiewicz A., Stalinska K., Jozkowicz A., Dulak J.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

7

The murine cellular model of mucopolysaccharidosis III, type B (MPS IIIB) - a preliminary study

44%

Kaczor-Kaminska M., Kaminski K., Stalinska K., Pisarek A., Feldman A., Wrobel M.

Acta Biochimica Polonica

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2018

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tom 65

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nr S2

8

Exogenous nitric oxide inhibits shedding of ADAM17 substrates

44%

Bzowska M., Stalinska K., Mezyk-Kopec R., Wawro K., Duda K., Das S., Bereta J.

Acta Biochimica Polonica

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2009

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tom 56

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nr 2

325-335

Both ADAM17, the secretase responsible for the shedding of ectodomains of numerous membrane proteins including TNF and its receptors, as well as nitric oxide synthesized by inducible nitric oxide synthase play regulatory roles in inflammation and tumor progression. We analyzed the effect of endogenous and exogenous nitric oxide on the expression and activity of ADAM17 in murine endothelial cells and a monocyte/macrophage cell line. We found that endogenous nitric oxide influenced neither ADAM17 mRNA level nor the shedding of two ADAM17 substrates, TNF and TNFR1. Exogenous NO significantly diminished the release of TNF and TNFR1 without affecting the ADAM17 transcript level. Our data seem contrary to a previous report that showed the activation of ADAM17 by nitric oxide (Zhang et al., 2000, J Biol Chem 275: 15839-15844). We discuss potential mechanisms of NO-mediated inhibition of ectodomain shedding and possible reasons of discrepancy between our results and the previous report.

Ograniczanie wyników

Receptory wiazace pozne produkty glikacji.

Glycated proteins as inducers of acute phase cytokines

Effect of glycosaminoglycans accumulation on the non-oxidative sulfur metabolism in mouse model of Sanfilippo syndrome, type B

Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants

Differential responses of hematopoietic and non-hematopoietic cells to anti-inflammatory cytokines: IL-4, IL-13 and IL-10

Regulation of vascular endothelial growth factor synthesis by doxycycline regulated overexpression of heme oxygenase-1

The murine cellular model of mucopolysaccharidosis III, type B (MPS IIIB) - a preliminary study

Exogenous nitric oxide inhibits shedding of ADAM17 substrates