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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Metoda oznaczania niektórych wielopierścieniowych węglowodorów aromatycznych (WWA) w powietrzu atmosferycznym

100%
Senczuk W., Kozielski J.
Roczniki Państwowego Zakładu Higieny
|
1977
|
tom 28
|
nr 6
2

Rifabutyna powoduje zmianę profilu ekspresji genów sigma Mycobacterium tuberculosis

81%
Pendzich J., Maksymowicz-Mazur W., Kozielski J.
Diagnostyka Laboratoryjna
|
2007
|
tom 43
|
nr 3
3
Content available remote

Dyspnea and quality of life in patients with pulmonary fibrosis after six weeks of respiratory rehabilitation

81%
Jastrzebski D., Gumola A., Gawlik R., Kozielski J.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 4
139-148
The aim of the study was to estimate the level of dyspnea and quality of life in patients with pulmonary fibrosis after 6 weeks' respiratory rehabilitation. The study comprised of 31 patients (F/M-12/19) with interstitial lung diseases (21 with idiopathic interstitial pneumonia, 4 with lung fibrosis due to allergic alveolitis, 4 with lung fibrosis due to collagenosis, 2 with lung fibrosis due to silicosis) who successfully finished the rehabilitation program. Each patient underwent an intensive (every day for 30 min) inpatient pulmonary rehabilitation program of an average length of 4 wk, continued later at home for up to 12 wk. The program consisted of respiratory muscle training and bicycle riding to the limits of the patient's tolerance. Dyspnea (MRC, OCD, BDI and Borg scale) and the quality of live (SF-36, St. George's Respiratory Questionnaire) were assessed at the time of admission and discharge. Rehabilitation caused dyspnea sensation to diminish (Borg scale: 2.97 before vs. 2.19 after). Some domains of the quality of life in SF-36 questionnaire (Role-Physical 40.6 vs. 60.2) and St. George's Respiratory Questionnaire (activity: 52 vs. 45, impact 47 vs. 40 and total 47 vs. 42) also were improved compared with the pre-rehabilitation results. We conclude that 12 weeks of combined inpatient and home-based rehabilitation programme improves the quality of live and sensation of dyspnea in patients with interstitial lung disease, despite changes in pulmonary function tests.
4
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Induced sputum metalloproteinases and their inhibitors in relation to exhaled nitrogen oxide and sputum nitric oxides and other inflammatory cytokines in patients with chronic obstructive pulmonary disease

81%
Ziora D., Dworniczak S., Kozielski J.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 6
809-817
5

Rifabutin influences selected Mycobacterium tuberculosis sigma genes expression profiles

81%
Pendzich J. B., Maksymowicz-Mazur W., Kozielski J.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr Supplement 4
6
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Badania zawartości jodu: w osoczu krwi, moczu, wątrobie i śledzionie w czasie narażenia zwierząt na działanie preparatu dezynfekcyjnego

81%
Senczuk W., Mlynarczyk W., Kozielski J.
Roczniki Państwowego Zakładu Higieny
|
1978
|
tom 29
|
nr 1
7

Postępy we współczesnej diagnostyce laboratoryjnej gruźlicy

81%
Pendzich J., Maksymowicz-Mazur W., Kozielski J.
Diagnostyka Laboratoryjna
|
2011
|
tom 47
|
nr 4
8
Content available remote

Correlation of spirometric parameters taken at a single examination with the quality of life in children with stable asthma

71%
Ziora D., Madaj A., Wieckowska E., Ziora K., Kozielski J.
Journal of Physiology and Pharmacology. Supplement
|
2007
|
tom 58
|
nr 5
9
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

High-resolution computer tomography in hypersensitivity pneumonitis-correlation with pulmonary function

71%
Ziora D., Jastrzebski D., Lubina M., Wojdala A., Kozielski J.
Annals of Agricultural and Environmental Medicine
|
2005
|
tom 12
|
nr 1
In 20 patients with chronic form of hypersensitivity pneumonitis (HP) pulmonary function tests (FEV1, FVC, DCO) and high resolution computed tomography (HRCT) scans were obtained. Extent of pathological changes, i.e. nodularity, lines, honeycombing but not ground-glass estimated by HRCT and expressed as a score correlated significantly with lung function abnormalities.
10
Content available remote

Potential confounding factors in measurement of exhaled nitric oxide

61%
Nadziakiewicz P., Knapik P., Rozentryt P., Ziora D., Dworniczak S., Kozielski J., Polonski L.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 4
223-228
Nitric oxide is present in the exhaled air. Factors affecting the level of exhaled nitric oxide (exNO), except for smoking, are not well defined. In this study we seek to determine whether age, gender, body mass index (BMI), part of the day, or time after a meal could modulate exNO levels. exNO was examined by the use of a chemiluminescence method in 100 subjects - 31 women (19 nonsmokers and 12 smokers) and 69 males (55 nonsmokers and 14 smokers). Forty four subjects took medications due to stable coronary disease, 22 were after heart transplantation, and 34 did not take any drugs. We found that exNO levels did not differ either between the whole groups of women and men or between smokers and nonsmokers of either respective group (4.91 ±2.38 vs. 6.27 ±4.23 ppb; 3.21 ±1.16 vs. 3.71 ±1.55 ppb; 5.98 ±2.35 vs. 6.92 ±4.45 ppb). The correlation of exNO with age in the whole population was weak (r=0.23; P=0.02) and insignificant in the smoking and nonsmoking subgroups. Likewise, correlations of exNO with BMI, part of the day, or time after a meal were insignificant in whole population as well as the subgroups. We conclude that the aforementioned factors are not able to confound the measurement of exNO in the population studied.
11
Content available remote

Late consequences of respiratory system burns

61%
Krzywiecki A., Ziora D., Niepsuj G., Jastrzebski D., Dworniczak S., Kozielski J.
Journal of Physiology and Pharmacology. Supplement
|
2007
|
tom 58
|
nr 5
12
Content available remote

Quality of life during one-year observation of patients with idiopathic pulmonary fibrosis awaiting lung transplantation

61%
Jastrzebski D., Kozielski J., Banas A., Cebula T., Gumola A., Ziora D., Krzywiecki A.
Journal of Physiology and Pharmacology. Supplement
|
2005
|
tom 56
|
nr 4
99-105
The aim of the study was to evaluate the quality of life and its changes in patients with idiopathic pulmonary fibrosis (IPF), waiting for lung transplantation. Sixteen IPF patients, who qualified for lung transplantation, and 14 chronic obstructive pulmonary disease (COPD) patients on long term oxygen therapy, taken as a reference group, were assessed. The quality of life was estimated twice, using an SF-36-questionnaire, at the time of qualification for lung transplantation and 12 months later. The IPF and reference patients had similarly profound disturbances in lung function and arterial blood gas content. The IPF patients had a statistically greater score in their physical functioning (PF; 45 vs. 18), the role of limitations due to physical problems (RP; 43 vs. 11), social functioning (SF; 58 vs. 30), and the role of emotional limitations in everyday life (RE; 65 vs. 12) than the reference ones. After a year's observation, there were no differences in SF-36 questionnaire results, except for the role of limitations due to physical problems (RP). A correlation was noted between spirometry and blood gas results and SF-36 questionnaire results in IPF patients qualified for lung transplantation. There was a positive correlation between the partial pressure of oxygen (PaO2), on one side, and mental and general health, on the other. There also were positive correlations between FEV1 and SF and FEV1 and the level of bodily pain (BP). We conclude that the SF-36 questionnaire is a sensitive tool to assess the quality of life in IPF patients qualified for lung transplantation. The information gained can help assess the severity of the disease, clinical symptoms, and functional impairment in these patients.
13
Content available remote

Correlation of exhaled nitric oxide with nitrogen oxides and selected cytokines in induced sputum of chronic obstructive pulmonary disease patients

61%
Ziora D., Dworniczak S., Kaczmarczyk G., Jastrzebski D., Krzywiecki A., Kozielski J.
Journal of Physiology and Pharmacology. Supplement
|
2007
|
tom 58
|
nr 5
14

Analiza profilu ekspresji wybranych genów kodujących podjednostki sigma polimerazy RNA w hodowlach Mycobacterium tuberculosis eksponowanych na etambutol

61%
Pendzich J., Maksymowicz-Mazur W., Mazurek U., Dworniczak S., Oklek K., Kozielski J., Wilczok T.
Diagnostyka Laboratoryjna
|
2004
|
tom 40
|
nr 3
15

Występowanie lekoopornych szczepów Mycobacterium sp. na terenie woj. śląskiego w latach 2000-2001

51%
Wojtyczka R. D., Dworniczak S., Pacha J., Idzik D., Kepa M., Wydmuch Z., Glab S., Oklek K., Kozielski J.
Diagnostyka Laboratoryjna
|
2002
|
tom 38
|
nr 3
16
Content available remote

Prognostic risk factors in patients with interstitial lung disease referred for lung transplantation

51%
Jastrzebski D., Kozielski J., Nowak J., Zielinska-Les I., Ziora D., Szulik B., Wojarski J., Zakliczynski M., Zembala M.
Journal of Physiology and Pharmacology. Supplement
|
2005
|
tom 56
|
nr 4
107-113
The aim of the study was to identify prognostic factors that would differentiate patients with interstitial lung disease between those with and without a chance to survive until lung transplantation. A retrospective study was performed in patients with interstitial lung disease referred for lung transplantation between September 1999 and April 2005. The analysis included the demographic data, the time from referral to transplantation, the functional tests (FVC, FEV1, FEV1%VC, the PaO2 at rest and after oxygen supplementation via a nasal catheter), the count of NYHA functional classes, the left ventricular ejection fraction (EF), the distance covered during a 6-min walk test, and the pathogens in the respiratory tract. The patients were divided into two groups: Group 1 - lung transplant candidates who survived until the successful procedure and Group 2 - lung transplant candidates who died while on the waiting list. There were statistical differences between the two groups in PaO2 after supplementation (P=0.005), EF (P=0.002), and the 6-min walk distance (P=0.001). It appears that simple functional tests of the cardiorespiratory system may define survival of patients with interstitial lung disease waiting for lung transplantation.
17
Content available remote

Right ventricular function in patients with severe interstitial lung disease: a tissue Doppler imaging study

51%
Nowak J., Jastrzebski D., Streb W., Rozentryt P., Wojarski J., Greif M., Kozielski J., Polonski L., Zembala M., Kukulski T.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 6
531-538
18
Content available remote

Human cytomegalovirus DNA level in patients with idiopathic pulmonary fibrosis

51%
Dworniczak S., Ziora D., Kapral M., Mazurek U., Niepsuj G., Rauer R., Wilczok T., Kozielski J.
Journal of Physiology and Pharmacology. Supplement
|
2004
|
tom 55
|
nr 3
67-75
The objectives of the study were to estimate human cytomegalovirus (HCMV) DNA copy number in broncho-alveolar lavage cells, blood leukocytes, and serum of patients with idiopathic pulmonary fibrosis (IPF). The study groups consisted of 16 patients, newly diagnosed with IPF and never treated, (mean age 40.9 ±11.0 yr; F/M-7/9) and in 16 adult healthy volunteers (mean age 36.8 ±6.4 yr; F/M-4/12) used as controls. The HCMV DNA copy number was calculated by a Q-PCR method using TaqMan ABI PRISMTM7700. We found that the prevalence of the HCMV DNA positive subjects in the patient group (75%) did not differ significantly from that in the control group (69%). We also found that in both patient and control groups the mean HCMV DNA copy number in BAL cells was significantly higher than that in blood leukocytes (log10=2.7 vs. 1.2 for patients and 2.8 vs. 0.9 for controls, respectively). However, a higher HCMV DNA copy number in blood serum was observed in IPF patients than in controls (log10=3.2 vs. 2.0, respectively). We conclude that the lungs play an important role in the human pathobiology of cytomegalovirus sustenance.
19
Content available remote

Left ventricular dysfunction in patients with interstitial lung diseases referred for lung transplantation

51%
Jastrzebski D., Nowak J., Ziora D., Wojarski J., Czyzewski D., Kozielski J., Polonski L., Zembala M.
Journal of Physiology and Pharmacology. Supplement
|
2007
|
tom 58
|
nr 5
20

PCR-RFLP analysis of a point mutation in codons 315 and 463 of the katG gene of Mycobacterium tuberculosis isolated from patients in Silesia, Poland

51%
Wojtyczka R. D., Dworniczak S., Pacha J., Idzik D., Kepa M., Wydmuch Z., Glab S., Bajorek M., Oklek K., Kozielski J.
Polish Journal of Microbiology
|
2004
|
tom 53
|
nr 2
Resistance to antituberculous agents is an important cause of ineffectiveness of antimicrobial therapy. The resistance of M. tuberculosis to antituberculous agents is a result of mutations in genes participating in those agent's action. The antituberculous drug - isoniazid can be activated by Mycobacterium tuberculosis either through a hydroperoxidase I/II or a superoxide-dependent oxyferrous pathway. The present study analyzed the frequency of the mutations occurring in codons 315 and 463 in katG gene of Mycobacterium tuberculosis strains, isolated from patients with pulmonary tuberculosis from Silesia, Poland. In this study 23 isoniazid-resistant Mycobacterium tuberculosis strains were analyzed. For RFLP analysis, a 620 bp amplified fragment of katG gene was digested with restriction endonuclease Mspl. Among 24 isoniazid-resistant strains, isolated from patients between 2000-2001, point mutations were found in 30% of analyzed isoniazid-resistant strains in codons 315 or 463 (7 strains). In contrast, no mutations in codons 315 and/or 463 katG gene were found in 16 strains (70%). Obtained results suggests that point mutations S315T (AGC—>ACC) and R463L in katG gene are infrequent in the analyzed population.
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