Wyniki wyszukiwania

1

Lymphocyte DNA damage in rats challenged with a single bout of strenuous exercise

100%

Wierzba T. H., Olek R. A., Fedeli D., Falcioni G.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 10

115-131

Exercise induces extensive generation of reactive oxygen species, which are responsible for tissue damage: enzymes inactivation, lipid peroxidation and single strand breaks in DNA. Defense system against free radicals is consisting of enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and numerous non-enzymatic antioxidants. The study was performed to evaluate the effect of a single bout of submaximal running exercise, on the lymphocyte DNA strand breaks and also to test how supplementation with tempol – a membrane-permeable SOD-mimetic (0.2 mmol/kg/day) influences the eventually evoked damage. Male, Wistar rats were challenged with graded 50 min. running on treadmill at intensity up to 75-85% of predicted O2 max. The DNA strand breaks in individual lymphocytes were determined by using a gel electrophoretic technique – “comet” assay. We found substantial lymphocyte DNA damage 60 min. after the exercise. Tempol failed to prevent from oxidative damage in rats challenged with exercise. Moreover tempol by itself induced higher DNA damage than the exercise bout.

2

New copper (I) compexes protect against DNA damage in rat epithelial cells induced by nitric oxide, niroxyl anion and peroxynitrite

88%

Fedeli D., Falcioni G., Santini C., Pellei M., Lobbia G. G.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

3

Biomembrane perturbation induced by xenobiotics in model and living systems

76%

Bertoli E., Ambrosini A., Zolese G., Gabbianelli R., Fedeli D., Falcioni G,

Cellular and Molecular Biology Letters

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2001

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tom 06

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nr 2A

334-339

4

NADH influences redox state of hemoproteins with an involvement of reactive oxygen species

76%

Olek R., Antosiewicz J., Popinigis J., Caulini G. C., Fedeli D., Falcion, Falcioni G.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

5

Antioxidant activity of hemoglobin

76%

Falcioni G., Caulini G. C., Fedeli D., Santroni A. M., Gabbianelli R., Kantar A.

Polish Journal of Environmental Studies

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1998

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tom 07

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nr 6

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Cellular and Molecular Biology Letters

1 Journal of Physiology and Pharmacology. Supplement

1 Polish Journal of Environmental Studies

5 Fedeli D.

4 Falcioni G.

2 Caulini G. C.

2 Gabbianelli R.

1 Ambrosini A.

1 Antosiewicz J.

1 Bertoli E.

1 Falcion

1 Falcioni G,

1 Kantar A.

1 Lobbia G. G.

1 Olek R.

1 Olek R. A.

1 Pellei M.

1 Popinigis J.

1 Santini C.

1 Santroni A. M.

1 Wierzba T. H.

1 Zolese G.

1 2006

2 2003

1 2001

1 1998

Lymphocyte DNA damage in rats challenged with a single bout of strenuous exercise

New copper (I) compexes protect against DNA damage in rat epithelial cells induced by nitric oxide, niroxyl anion and peroxynitrite

Biomembrane perturbation induced by xenobiotics in model and living systems

NADH influences redox state of hemoproteins with an involvement of reactive oxygen species

Antioxidant activity of hemoglobin