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1

Flavonoids in the prevention of age-related cognitive decline

100%
Widy-Tyszkiewicz E.
Herba Polonica. Suplement
|
2005
|
tom 51
|
nr 1
2

Ginkgo biloba and Hypericum perforatum - the mechanism of their effects on memory and learning processes

100%
Widy-Tyszkiewicz E.
Herba Polonica
|
2003
|
tom 49
|
nr 3-4
3

Badania neurobehawioralne w farmakologii

63%
Piechal A., Widy-Tyszkiewicz E.
Prace i Materiały Zootechniczne
|
2008
|
tom 66
4

A randomized double blind study of sedative effects of phytotherapeutic containing valerian, hops, balm and motherwort versus placebo

63%
Widy-Tyszkiewicz E., Schminda R.
Herba Polonica
|
1997
|
tom 43
|
nr 2
154-159
Celem pracy była ocena uspokajającego i nasennego działania ziołowego preparatu złożonego z korzenia waleriany, szyszek chmielu, liści melisy i ziela serdecznika. Badaniem objęto 50 mężczyzn uzależnionych od alkoholu z zespołem abstynencji i bezsennością. W porównaniu z grupą placebo stwierdzono statystycznie istotną poprawę jakości snu, jednak po rannym przebudzeniu występowała większa senność. Podanie preparatu ziołowego znamiennie zmniejszyło występowanie koszmarów sennych i częstość przebudzeń w nocy.
5

Interakcje lekow roslinnych stosowanych w chorobach ukladu oddechowego

51%
Blecharz-Klin K., Piechal A., Pyrzanowska J., Widy-Tyszkiewicz E.
Herba Polonica
|
2005
|
tom 51
|
nr 3-4
87-105
Leki roślinne są często stosowane w terapii schorzeń układu oddechowego. Gdy są przyj­mowanie jednocześnie z lekami konwencjonalnymi, zwiększa to ryzyko wystąpienia inter­akcji ze składnikami farmakologicznie czynnymi roślin leczniczych. Na podstawie zarówno wyników badań klinicznych, jak i doświadczeń przedklinicznych omówiono najczęściej używane preparaty pochodzenia roślinnego. Przedstawiono najczęstsze interakcje wpływające w znacznym stopniu na przebieg terapii schorzeń układu oddechowego.
6

Place learning in spontaneously hypertensive, renal hypertensive and normotensive Wistar rats

51%
Widy-Tyszkiewicz E., Scheel-Kruger J., Christensen A. V.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 3
7

Peripheral antinociceptive effect of MU and kappa opioid receptor agonists in normotensive wistar (NR), wistar Kyoto (WKY) and spontaneousily hypertensive rats (SHR)

51%
Mierzejewski P., Widy-Tyszkiewicz E., Kohutnicka M., Czlonkowski A.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 3
8

Interakcje lekow roslinnych stosowanych w chorobach ukladu pokarmowego

51%
Pyrzanowska J., Piechal A., Blecharz-Klin K., Widy-Tyszkiewicz E.
Herba Polonica
|
2006
|
tom 52
|
nr 1-2
75-96
9

The contribution of the hypertensive state to the experimental model of chronic pain

51%
Kohutnicka M., Widy-Tyszkiewicz E., Mierzejewski P., Czlonkowski A.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 3
10

Wpływ wieku i suplementacji kurkuminą na skuteczność mechanizmów detoksykacyjnych w tkankach szczura

45%
Gutowicz M., Augustyn A., Pyrzanowska J., Widy-Tyszkiewicz E., Baranczyk-Kuzma A.
Medycyna Weterynaryjna
|
2011
|
tom 67
|
nr 01
Curcumin is a yellow pigment extracted from the rhizome of Curcuma Longa. It has been used in Asia for several thousand years as a spice, antibacterial, anti-inflammatory and digestive agent. Current research reports that curcumin exhibits antioxidative, anticancer and neuroprotective properties. The aim of this study was to compare the activity of catalase (CAT), glutathione S-transferase (GST) and arginase (ARG) in the rat kidney, heart and skeletal muscle during aging, as well as to determine the effect of systematic curcumin supplementation on the activity of the above enzymes in old animals. Studies were conducted on adult (6 months of age) and old (22 months of age) Wistar Albino Glaxo males. The animals were separated into four groups of 7-8 rats each. Groups I and II were given a standard diet without curcumin, groups III and IV were on a diet supplemented with 10 and 50 mg/kg b.w. of curcumin, respectively. Ageing was observed to have no effect on CAT activity in any of the tissues under investigation, whereas GST activity decreased in both the kidney and the skeletal muscle but not in the heart. In the kidney the level of GSH significantly decreased, but ARG activity increased. After the administration of curcumin to old rats, the activities of CAT and GST increased in the kidney and the skeletal muscle, but not in the heart. The level of GSH was higher in the kidney, but ARG activity remained unchanged. Thus, curcumin supplementation has a positive effect on detoxification processes in extrahepatic tissues of old rats.
11

Pharmacological and biochemical effects of Ginkgo biloba extract of learning, memory consolidation and motor activity in old rats

45%
Blecharz-Klin K., Piechal A., Joniec I., Pyrzanowska J., Widy-Tyszkiewicz E.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 2
217-231
Effect of administration of the standardized extract of Ginkgo biloba leaves (EGb 761) on learning, memory and exploratory behavior was estimated in water maze and hole-board tests. Rats (18-month old) received for three months EGb 761 at doses: 50, 100 and 150 mg/kg b.w. per day. After completion of the behavioral experiment, concentrations of neurotransmitters were estimated in selected brain regions. ANOVA demonstrated significant differences in the content of monoamines and metabolites between the treatment groups compared to the control. The increased level of 5-hydroxytryptamine (5-HT) in the hippocampus and 5-HIAA (5-HT metabolite) in the prefrontal cortex correlated positively with the retention of spatial memory. Positive correlation between platform crossings in SE during the probe trial and neurotransmitter turnover suggest improvement of spatial memory. Long-term administration of Ginkgo biloba extract can improve spatial memory and motivation with significant changes in the content and metabolism of monoamines in several brain regions.
12

Wpływ długotrwałego podawania rutyny na pamięć przestrzenną i neuroprzekaźnictwo u szczurów

45%
Pyrzanowska J., Blecharz-Klin K., Piechal A., Joniec-Maciejak I., Widy-Tyszkiewicz E.
Annals of Warsaw University of Life Sciences - SGGW. Animal Science
|
2011
|
tom 48
13

Wplyw kurkuminy na detoksykacyjne i antyoksydacyjne mechanizmy w watrobie szczurow podczas starzenia

45%
Gutowicz M., Cholojczyk M., Pyrzanowska J., Widy-Tyszkiewicz E., Baranczyk-Kuzma A.
Medycyna Weterynaryjna
|
2008
|
tom 64
|
nr 07
955-957
Curcumin (diferuloylmethane), a yellow poliphenol pigment isolated from rhizome of Curcuma longa, has been used throughout Asia for several thousands of years. Beside giving curry dishes their color, curcumin has been reported as an agent used in the treatment of various disorders. The aim of this study was to determine the effect of chronic curcumin administration on enzymatic and nonenzymatic protective mechanisms in the livers of aging rats. The liver was isolated from Wistar Albino Glaxo rats, age 6 and 22 months. All rats were fed a standard chow diet. Two groups of older animals were given a standard diet supplemented either with 10 mg/kg b.w. or with 50 mg/kg b.w. of curcumin powder for 10 weeks before their sacrifice. Malondialdehyde level, reduced glutathione, the activity of catalase, glutathione S-transferase, and arginase were determined. Increased lipid peroxidation was observed in old rat livers, elevated catalase and arginase activities, as well as the level of reduced glutathione in curcumin fed animals. No changes in glutathione S-transferase activity were found. It may be concluded that curcumin administered in a diet exerts an antioxidant effect and protects the liver against ammonia intoxication.
14

Mice lines divergently selected for body mass show significant differences in spatial learning

45%
Blecharz-Klin K., Piechal A., Pyrzanowska J., Wirth-Dzieciolowska E., Widy-Tyszkiewicz E.
Polish Journal of Natural Sciences
|
2015
|
tom 30
|
nr 1
The present study was aimed to investigate the influence of multigenerational selection in the direction of low or high body weight on spatial learning and memory in mice. Light and heavy lines of rodents were selected from an outbred stock constructed from inbred strains; A/St, BN/a, BALB/c and C57BL/6J. Male mice selected at weaning for the low (L, n=13) or high (H, n=16) body weight for 94 generations have been evaluated for behavioral performance and cognition in the modified Morris water maze task. The unselected control line (Con, n=15) was run in parallel. Presented results lead to the conclusion that selection of mice for high and low body weight over 94 generations resulted in a significant differentiation in learning abilities. Our findings suggest improvement of learning of the hidden platform position in heavy line of mice.
15
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Whey administration modulates spatial memory in a water maze

39%
Blecharz-Klin K., Piechal A., Joniec I., Zobel A., Pyrzanowska J., Widy-Tyszkiewicz E.
Journal of Pre-Clinical and Clinical Research
|
2011
|
tom 05
|
nr 1
16
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Content available

Administration of Greek Royal Jelly produces fast response in neurotransmission of aged Wistar male rats

39%
Pyrzanowska J., Piechal A., Blecharz-Klin K., Joniec-Maciejak I., Graikou K., Chinou J., Widy-Tyszkiewicz E.
Journal of Pre-Clinical and Clinical Research
|
2015
|
tom 09
|
nr 2
Introduction. Royal Jelly (RJ) is a popular bee-derived product used widely in European and Asian traditional medicine. RJ has some pharmacological activities to support health and longevity as well as prevent ageing. Objectives. To evaluate whether a short-term 6-day Royal Jelly administration is able to induce behavioural and neurochemical effects in aged rats. Materials and method. RJ (previously chemically characterized by GC-FID and GC–MS) was given to 18-month-old male Wistar rats (100 and 500mg of powder/kg b.w./day) in subcutaneous injection for 6 days. Spatial memory was assessed in a water maze. Afterwards, the level of neurotransmitters, their metabolites and turnover in the selected brain regions were estimated by HPLC. Results. Short-term RJ administration did not change spatial memory in aged rats in the water maze, although it was sufficiently active to modify most of all the serotonergic and dopaminergic transmission in the prefrontal cortex and hippocampus. Conclusion. The obtained results indicate that Royal Jelly is able to affect very quickly the neurotransmission in the brain structures responsible for cognitive performance; however, short-term administration is not sufficient to exert behavioural consequences.
17
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Content available

Dihydroergotamine affects spatial behavior and neurotransmission in the central nervous system of Wistar rats

39%
Piechal A., Blecharz-Klin K., Joniec-Maciejak I., Pyrzanowska J., Krzysztoforska K., Mirowska-Guzel D., Widy-Tyszkiewicz E.
Annals of Agricultural and Environmental Medicine
|
2021
|
tom 28
|
nr 3
18

The role of neurogenesis in learning:studies of cyclin D2 knock-out mice

33%
Filipkowski N. P., Kiryk A., Knapska E., Jaholkowski P., Kowalczyk A., Piechal A., Blecharz-Klin K., Widy-Tyszkiewicz E., Kaczmarek L.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
19

New hippocampal neurons are not obligatory for memory formation:mice with no adult brain neurogenesis show learning

27%
Jaholkowski P., Kiryk A., Jedynak P., Ben Abdallah N., Knapska E., Kowalczyk A., Piechal A., Blacharz-Klin K., Widy-Tyszkiewicz E., Wilczynski G., Lipp H., Kaczmarek L., Filipkowski R.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
New neurons are produced in the brains of adult animals, including humans, throughout the lifespan. Since one of the site of adult brain neurogenesis is the hippocampal formation, a brain structure involved in learning and memory, new neurons were expected to be involved in these phenomena. However, the very evidence supporting this hypothesis remains limited, inconsistent and in most cases indirect. Also, the experiments in which adult neurogenesis is blocked use irradiation and drugs known for their side effects. We used a novel approach, cyclin D2 knock-out mice (D2 KO mice), specifi cally lacking adult brain neurogenesis (which was verifi ed using DCX and NeuN staining) to verify its importance in learning and memory. D2 KO mice and their wild type siblings were tested in several behavioral paradigms including those in which the role of adult neurogenesis has been postulated. D2 KO mice showed no impairment in sensorimotor tests with only sensory impairment in an olfaction-dependent task. However, D2 KO mice showed proper procedural learning as well as learning in context (including remote memory), cue and trace fear-conditioning, Morris water maze, novel object recognition test, and in a multifunctional behavioral system – Intellicages. Our results suggest that adult brain neurogenesis is not obligatory in learning, including the kinds of learning where the role of adult neurogenesis has previously been strongly suggested. Support – MNiSW grant no N303 051 31/1624.
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