Wyniki wyszukiwania

1

Serum level of oxidative stress markers during renal transplantation

100%

Biernacki M., Jankowski K., Wozniak M., Sledzinski Z.

Acta Biochimica Polonica

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2003

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tom 50

|

nr Supplement 1

2

Antioxidative effect of resveratrol on the prevention of experimental acute pancreatitis

88%

Lawinski M., Sledzinski Z., Wozniak M., Juraniec-Kubasik J., Boguslawski W.

Acta Biochimica Polonica

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2003

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tom 50

|

nr Supplement 1

3

The morphology of acinar cells during acute pancreatitis in rats induced by intraductal infusion of peracetate

88%

Jankowski K., Kubasik-Juraniec J., Sledzinski Z., Spodnik J. H., Wozniak M.

Folia Morphologica

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2004

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tom 63

|

nr 2

Many experimental models have been created to explain the pathophysiology of acute pancreatitis (AP). Investigations have been undertaken in this laboratory into the influence of strong oxidants introduced into the pancreas retrogradely through the bile-pancreatic duct. In these experiments a potentially toxic metabolite of ethanol-peracetic acid was used to induce AP. Wistar rats were treated with 1 mM and 40 mM peracetate and with a solvent as a control for 1 and 3 hours respectively. After a period of observation the samples of pancreata were examined in a light and electron microscope together with the content of sulphydryl groups as a marker of intracellular oxidative stress. The morphological examination showed profound changes in the histology of the pancreas and also in its subcellular structures, especially in groups 3 and 4 (with a higher concentration of peracetate). The changes included parenchymal haemorrhage and widespread acinar cell necrosis. The level of the sulphydryl groups decreased in the rats treated with peracetate. This suggests that the severity of the disease strongly depends on the intensity of the oxidative stress. The results confirmed the axial role of oxygen-derived free radicals in the pathogenesis of AP.

4

Kinetic properties of AMP deaminase in acute experimental pancreatitis

88%

Kossowska E., Purzycka-Preis J., Wozniak M., Zydowo M., Sledzinski Z.

Acta Biochimica Polonica

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1994

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tom 41

|

nr 2

5

Oxidative stress-dependent protein modification as a new signal for accelerated proteolysis in acute pancreatitis

76%

Sledzinski Z., Wozniak M., Kossowska E., Jankowski K., Stanek A., Wajda Z.

Journal of Physiology and Pharmacology. Supplement

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1998

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tom 49

|

nr 2

6

Pancreatic remnant fate

64%

Hac S., Pienkowska J., Madejewska I., Laski D., Kostro J., Mroczkowski P., Studniarek M., Sledzinski Z.

Folia Morphologica

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2015

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tom 74

|

nr 1

There is eternal discussion on the best surgical method of pancreatoduodenectomy and reconstruction method. Several different methods of pancreatic stump anastomosis exist. The most popular argument taken into account in the discussion is the frequency of early postoperative complications. Relatively fewer papers analyse the late functional outcome of pancreatic surgery and the method of anastomosis employed. Authors presented short series of 12 patients after pancreatic surgery with analysis of pancreatic remnant morphology and function. Pancreatic remnant volume, pancreatic duct distension and stool elastase-1 test were analysed. There was no correlation of pancreatic exo- or endocrine insufficiency with the volume of pancreatic remnant or the kind of surgery or anastomosis performed. (Folia Morphol 2015; 74, 1: 56–60)

7

The animal model of acute pancreatitis induced by synthetic prooxidant

64%

Sledzinski Z., Wozniak M., Brunelli A., Scutti G., Stanek A., Bertoli E., Lezoche E., Wajda Z.

Polish Journal of Environmental Studies

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1998

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tom 07

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nr 6

8

Dynamics of estrogen-induced oxidative stress

51%

Kobiela J., Stefaniak T., Krajewski J., Kalinska-Blach B., Zurawa-Janicka D., Lachinski A., Gackowski D., Olinski R., Nowak J., Knap N., Lipinska B., Sledzinski Z., Wozniak M.

Acta Biochimica Polonica

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2007

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tom 54

|

nr 2

The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.

Ograniczanie wyników

Serum level of oxidative stress markers during renal transplantation

Antioxidative effect of resveratrol on the prevention of experimental acute pancreatitis

The morphology of acinar cells during acute pancreatitis in rats induced by intraductal infusion of peracetate

Kinetic properties of AMP deaminase in acute experimental pancreatitis

Oxidative stress-dependent protein modification as a new signal for accelerated proteolysis in acute pancreatitis

Pancreatic remnant fate

The animal model of acute pancreatitis induced by synthetic prooxidant

Dynamics of estrogen-induced oxidative stress