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The role of the periventricular tissue of the anteroventral third ventricle in body fluid homeostasis

100%

Johnson A. K.

Acta Physiologica Polonica

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1988

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tom 39

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nr 1

2

A brain stem system and the inhibition of extracellular depletion-induced drinking

63%

Johnson A. K., Ohman L. E.

Acta Physiologica Polonica

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1988

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tom 39

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nr 1

3

The role of basal forebrain norepinephrine and the control of extracellular depletion-induced drinking

63%

Johnson A. K., Cunningham T.

Acta Physiologica Polonica

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1989

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tom 40

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nr 3

4

Sadness and broken hearts: neurohumoral mechanisms and co-morbidity of ischemic heart disease and psychological depression

63%

Johnson A. K., Grippo A. J.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 11

5-29

Heart disease and depression are highly co-morbid. Clinical and experimental research over the past 70 years has led to several neurohumoral hypotheses of causative factors present under the conditions of either heart failure or of psychological depression. Some of these hypothesized factors are common to both disorders and are therefore attractive candidates to account for the high incidence of co-occurrence of depression and heart disease. One experimental approach to study the co-morbidity of heart failure and depression has been to study the behavioral, biochemical and physiological changes in a chronic mild stress model of depression and in heart failure induced by experimental myocardial infarction. Our studies have led us to focus on the pro-inflammatory cytokines, in particular tumor necrosis factor (TNF)-alpha, and the renin-angiotensin-aldosterone system. Both of these families of humoral factors are elevated in human heart failure and in depression and the two experimental models we have studied. The demonstrated validity of each of these models will be of great value in elucidating the nature of the actions and interactions of these humoral agents as they contribute to the co-morbid conditions of heart failure and depression.

Ograniczanie wyników

3 Acta Physiologica Polonica

1 Journal of Physiology and Pharmacology. Supplement

4 Johnson A. K.

1 Cunningham T.

1 Grippo A. J.

1 Ohman L. E.

1 2006

1 1989

2 1988

The role of the periventricular tissue of the anteroventral third ventricle in body fluid homeostasis

A brain stem system and the inhibition of extracellular depletion-induced drinking

The role of basal forebrain norepinephrine and the control of extracellular depletion-induced drinking

Sadness and broken hearts: neurohumoral mechanisms and co-morbidity of ischemic heart disease and psychological depression