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1

Thyroliberin (TRH) and release of neurohypophysical hormones in the rat:in vitro studies

100%
Ciosek J.
Acta Neurobiologiae Experimentalis
|
1992
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tom 52
|
nr 3
2
Content available remote

Vasopressin and oxytoxin release as influenced by thyrotropin-releasing hormone in euhydrated and dehydrated rats

100%
Ciosek J.
Journal of Physiology and Pharmacology
|
2002
|
tom 53
|
nr 3
Since the thyrotropin-releasing hormone (TRH) can modulate the processes of vasopressin (AVP) and oxytocin (OT) biosynthesis and release mainly at the hypothalamo-neurohypophysial level, the present experiments were undertaken to estimate whether TRH, administered intravenously in different doses, modifies these mechanisms under conditions of osmotic stimulation, brought about by dehydration. AVP and OT contents in the hypothalamus and neurohypophysis as well as plasma levels of AVP, OT, free thyroxine (FT4) and free triiodothyronine (FT3) were studied after intravenously TRH treatment in euhydrated and dehydrated for two days male rats. Under conditions of equilibrated water metabolism TRH diminished significantly the hypothalamic and neurohypophysial AVP and OT content but was without the effect on plasma oxytocin level; however, TRH in a dose of 100 ng/100 g b.w. raised plasma AVP level. TRH, injected i.v. to dehydrated animals, resulted in a diminution of AVP content in the hypothalamus but did not affect the hypothalamic OT stores. After osmotic stimulation, neurohypophysial AVP and OT release was significantly restricted in TRH-treated rats. Under the same conditions, injections of TRH were followed by a significant decrease of plasma OT level. I.v. injected TRH enhanced somewhat FT3 concentration in blood plasma of euhydrated animals but diminished FT4 plasma level during dehydration. Data from the present study suggest that TRH displays different character of action on vasopressin and oxytocin secretion in relation to the actual state of water metabolism.
3

Thyroliberin (TRH) and release of vasopressin and oxytocin from the rat hypothalamo-neurohypophysial explants in vitro

63%
Ciosek J., Stempniak B.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
4

Porównanie zawartości wazopresyny (AVP) w części nerwowej przysadek u szczurów oznaczanej metodą radioimmunologiczną i metodą Dekańskiego

63%
Orlowska-Majdak M., Ciosek J.
Diagnostyka Laboratoryjna i Wiadomości PTDL
|
1992
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tom [29]
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nr 2
5

Galanin and vasopressin response to hyperosmotic stimulation: in vitro study

63%
Ciosek J., Galecka K.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr 4
Galanin (Gal) - a neuropeptide present in the nervous system and peripheral tissues - may be involved in the regulation of hypothalamo-neurohypophysial system function. It was shown that centrally injected galanin inhibits osmotically stimulated vasopressin (VP) secretion into the blood and reduces VP mRNA level in the supraoptic (SON) and paraventricular (PVN) hypothalamic nuclei. The aim of the present study in vitro was to investigate the influence of Gal on vasopressin release from isolated rat hypothalamus (Hth), neurohypophysis (NH) or hypothalamo-neurohypophysial explants (Hth-NH). The effect of Gal on VP secretion was studied under conditions of direct osmotic (i.e., Na+-evoked) (series 1) as well as non- osmotic (i.e., K+-evoked) (series 2) stimulation. In series 3, vasopressin response to Gal was studied using the neural tissues obtained from animals drinking 2% NaCl solution for eight days (indirect osmotic stimulation). Gal in a concentration of 10"10 M and 10-8 M inhibited basal VP release from Hth, NH and Hth-NH explants isolated from euhydrated rats as well as from Hth-NH complex of osmotically challenged animals. When the neural tissues obtained from previously salt-loaded rats were incubated in K+-enriched medium the inhibitory effect of Gal was completely blocked. It may be concluded that the effect of Gal is depending on the current functional status of the hypothalamo-neurohypophysial system.
6
Content available remote

Thyrotropin-releasing hormone modulates vasopressin and oxytocin synthesis and release from the hypothalamo-neurohypophysial system of different age male rats

63%
Ciosek J., Izdebska K.
Journal of Physiology and Pharmacology
|
2009
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tom 60
|
nr 2
63-70
Thyrotropin-releasing hormone (TRH) is engaged in the modulation of the hypothalamo-neurohypophysial system activity. Effects of repeated intravenously injections of TRH in a dose of 100 ng/100 g b.w. on vasopressin (VP) and oxytocin (OT) biosynthesis and release from the hypothalamo-neurohypophysial system was investigated in rats in different age (1-, 3- or 7-months of the life). To estimate the biosynthesis rate of both neurohormones the colchicine procedure was used (the dose of 5 µg/5 µl icv 20 hours before the decapitation). It has been observed that vasopressin synthesis in the hypothalamus increased gradually with maturation of rats, while OT biosynthesis decreased in the same animals. Hypothalamic biosynthesis rate of VP and OT is most effective in youngest rats and declines during the adolescence of animals. Thyrotropin-releasing hormone directly affects VP-ergic and OT-ergic hypothalamic neurons activity and both neurohormones biosynthesis process. This effect, however, is opposed: TRH acts as a stimulator of vasopressin biosynthesis most of all in young male rats and as an inhibitor for oxytocin biosynthesis especially in mature animals.
7
Content available remote

Galanin influences vasopressin and oxytocin release from the hypothalamo-neurohypophysial system of salt-loaded rats

63%
Cisowska-Maciejewska A., Ciosek J.
Journal of Physiology and Pharmacology
|
2005
|
tom 56
|
nr 4
Galanin is a peptide present in the nervous system and peripheral tissues which exerts a broad range of physiological functions. The influence of centrally administered galanin (Gal; 100 pM i.c.v.) on arginine vasopressin (AVP) and oxytocin (OT) content in the hypothalamus and neurohypophysis as well as on their blood plasma concentration was estimated in male Wistar rats drinking ad libitum 2% solution of natrium chloride per 48 hours. In euhydrated rats and subsequently applied i.c.v. with Gal a significant fall in the hypothalamic and neurohypophysial content of OT but not AVP was observed, however, without simultaneous changes in these neurohormones blood plasma concentration. On the contrary, i.c.v. injection of Gal to salt-loaded rats caused a marked raise in AVP and OT level in the hypothalamus and neurohypophysis with subsequent diminution of both neurohormones concentration in blood plasma. These results suggest that in euhydrated rats Gal has an inhibitory influence on the biosynthesis as well as axonal transport of OT, but not AVP. On the contrary, in salt-loaded rats galanin restricts secretion of both neurohormones into the systemic circulation.
8
Content available remote

Centrally administered galanin modifies vasopressin and oxytocin release from the hypothalamo-neurohypophysial system of euhydrated and dehydrated rats

63%
Ciosek J., Cisowska A.
Journal of Physiology and Pharmacology
|
2003
|
tom 54
|
nr 4
Galanin (Gal) as a neuropeptide with widespread distribution in the central nervous system may be involved in the mechanisms of vasopressin (AVP) and oxytocin (OT) release from the hypothalamo-neurohypophysial system. Vasopressin and oxytocin content in the hypothalamus and neurohypophysis as well as plasma level of both neurohormones were studied after galanin treatment in euhydrated and dehydrated rats. In not dehydrated rats intracerebroventricular (i.c.v.) injections of Gal did not affect the hypothalamic and neurohypophysial OT content, however, distinctly increased plasma OT concentration. In the same animals Gal diminished the hypothalamic AVP content but was without the effect on neurohypophysial AVP storage; plasma AVP level then raised. Galanin, administered i.c.v. to rats deprived of water, distinctly inhibited AVP and OT release from the hypothalamo-neurohypophysial system. Simultaneously, plasma AVP and OT level was significantly diminished after Gal treatment in dehydrated rats. These results suggest that modulatory effect of galanin on vasopressin and oxytocin release depends on the actual state of water metabolism. Gal acts as an inhibitory neuromodulator of AVP and OT secretion under conditions of the dehydration but stimulates this process in the state of equilibrated water metabolism.
9
Content available remote

Vasopressin and oxytocin release and the thyroid function

63%
Ciosek J., Drobnik J.
Journal of Physiology and Pharmacology
|
2004
|
tom 55
|
nr 2
The aim of the present investigations was to examine the effects of the states of hypothyroidism or hyperthyroidism on vasopressin (AVP) and oxytocin (OT) release under conditions of equilibrated water metabolism as well as of osmotic stimulation, brought about by the dehydration or hypertonic saline administration. The euhydrated and simultaneously hypothyroid rats showed decreased hypothalamic AVP and OT content and somewhat higher but not significant neurohypophysial AVP content. In these animals the raised OT (but not AVP) plasma level has been observed. In hyperthyroid rats drinking tap water ad libitum the neurohypophysial AVP and OT content significantly diminished; plasma OT concentration (but not AVP) was then elevated. The state of osmotic stimulation was the reason of different response of the hypothalamo-neurohypohysial system function in hypo- or hyperthyroid rats. Significant decreases of neurohypophysial AVP and OT content were found in both hypothyroid dehydrated as well as hypothyroid hypertonic saline-treatment rats as compared with hypothyroid euhydrated ones. On the contrary, in the state of hyperthyroidism AVP content in the neurohypophysis distinctly raised in dehydrated and salt-loaded rats; in these last neurohypophysial OT content increased as well. Plasma OT (but not AVP) distinctly diminished in hyperthyroid and simultaneously dehydrated or hypertonic saline injected rats in relation to hyperthyroid control subgroup. Data from the present study suggest that: 1) altered thyroid gland function affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in the state of equilibrated water metabolism; 2) the state of hypo- or hyperthyroidism modifies the response of AVP-ergic and OT-ergic neurons upon the osmoreceptors/osmodetectors stimulation. It may be sypposed that OT-ergic neurons display greater than AVP-ergic neurons sensitivity upon the thyroid hormone influence.
10
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Content available

Thyrotropin-releasing hormone affects the oxytocin, vasopressin and prolactin release in female rats during midlactation: relation to suckling

63%
Ciosek J., Guzek J. W.
Journal of Physiology and Pharmacology
|
1998
|
tom 49
|
nr 1
11
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Content available

The influence of vasopressin or oxytocin on thyroid-stimulating hormone and thyroid hormones' concentrations in blood plasma of euthyroid rats

63%
Ciosek J., Stempniak B.
Journal of Physiology and Pharmacology
|
1997
|
tom 48
|
nr 4
12
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Thyrotropin-releasing hormone [TRH] modifies oxytocin release from the hypothalamo-neurohypophysial system in salt-loaded rats

63%
Ciosek J., Stempniak B.
Journal of Physiology and Pharmacology
|
1995
|
tom 46
|
nr 2
13

Thyrotropin-releasing hormone [TRH] inhibits vasopressin and oxytocin release from rat hypothalamo-neurohypophysial explants in vitro

63%
Ciosek J., Stempniak B.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 1
14

The relase of neurohypophysial hormones as influenced by stimulation of alpha-adrenergic transmission in long- term dehydrated male white rats. Information 2: hypothalamic and neurohypophysial oxytocic activity

51%
Guzek J. W., Janus J., Ciosek J.
Acta Physiologica Polonica
|
1981
|
tom 32
|
nr 2
15

The vasopressour and oxytocic activites of the hypothalamus and neurohypophysis are influenced by ithibited alpha-adrenergic transmission during dehydration and subsequent rehydration in the white rat

51%
Guzek J. W., Janus J., Ciosek J.
Acta Physiologica Polonica
|
1981
|
tom 32
|
nr 6
16

The vasopressor and oxytocic activities of the hypothalamus and neurohypophysis influenced by stimulated alpha-adrenergic tranmission during dehydration and susequent rehydration in the white rat

51%
Ciosek J., Guzek J. W., Morawska J.
Acta Physiologica Polonica
|
1983
|
tom 34
|
nr 3
17

The relase of neurohypophysial hormones as influenced by stimulation of alpha-adrenergic transmission in long- term dehydrated male white rats. Information 1: hypothalamic and neurohypophysial vasopressor activity

51%
Guzek J. W., Ciosek J., Janus J.
Acta Physiologica Polonica
|
1981
|
tom 32
|
nr 2
18

Thyroliberin (TRH) affects the oxytocin and prolactin release in female rats during midlactation

51%
Ciosek J., Guzek J. W., Stempniak B., Dabrowski R.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
19
Content available remote

Galanin affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in haemorrhaged rats

51%
Ciosek J., Cisowska A., Dabrowski R.
Journal of Physiology and Pharmacology
|
2003
|
tom 54
|
nr 2
The effect of centrally administered galanin (Gal; 100 pM i.c.v.) on the hypothalamo-neurohypophysial storage as well as blood plasma level of vasopressin and oxytocin was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats. Gal i.c.v. treatment did not alter vasopressin and oxytocin content both in the hypothalamus and neurohypophysis as well as their concentration in blood plasma of not haemorrhaged rats. Haemorrhage decreased the hypothalamic and neurohypophysial vasopressin and oxytocin storage but increased the neurohormones plasma level in animals injected with vehicle solution. During the haemorrhage, the increase in plasma vasopressin and oxytocin was inhibited in rats previously treated i.c.v. with galanin. The hypothalamic and neurohypophysial vasopressin as well as oxytocin content significantly increased in animals treated with galanin and subsequently haemorrhaged. These results suggest that galanin may have a regulatory role in the hypothalamo-neurohypophysial function especially under condition of hypovolemia.
20
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Thyrotropin-releasing hormone [TRH] modulates vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in dehydrated rats

51%
Ciosek J., Guzek J. W., Orlowska-Majdak M.
Journal of Physiology and Pharmacology
|
1993
|
tom 44
|
nr 3
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