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1

IRP1, bialko kontrolujace homeostaze zelaz w komorkach ssakow: regulacja jego aktywnosci przez jony zelaza i tlenek azotu.

100%
Starzynski R. R., Lipinski P.
Postępy Biologii Komórki
|
2003
|
tom 30
|
nr 3
497-514
2

A characterization of the activities of iron regulatory protein 1 in various farm animal species

81%
Starzynski R. R., Gralak M. A., Smuda E., Lipinski P.
Cellular and Molecular Biology Letters
|
2004
|
tom 09
|
nr 4A
651-664
Iron regulatory protein 1 (IRP1) post-transcriptionally regulates the expression of proteins involved in the iron metabolism of mammals. IRP1 is a bifunctional cytosolic protein which can exhibit aconitase activity or bind to iron responsive element (IREs) in the untranslated regions of specific mRNAs. The modulation of IRP1 activities and its consequence for intracellular iron homeostasis is best characterized in rodents and humans. Little is known about IRP1 in farm animals. In this study, we analyzed the two activities of IRP1 in the livers of four farm animal species (cattle, goat, pig and rabbit) and their relationship to hepatic iron content. We found an inverse correlation between spontaneous IRP1 IRE binding activity and non-haem iron content in the liver. Using the electrophoretic mobility shift assay, we showed differential mobility of IRE/IRP1 complexes formed with hepatic cytosolic extracts from various farm animal species. We discuss this observation in relation to a comparative analysis of mammalian IRP1 amino acid sequences.
3
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The role of iron regulatory proteins in the control of iron metabolism in mammals

81%
Stys A., Starzynski R. R., Lipinski P.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2011
|
tom 92
|
nr 1
4

Homeostaza żelaza – mechanizm obronny w stresie oksydacyjnym

81%
Lipinski P., Starzynski R. R., Stys A., Stracilo M.
Postępy Biochemii
|
2010
|
tom 56
|
nr 3
5

Alkohol a metabolizm żelaza

81%
Lipinski P., Stys A., Starzynski R. R.
Kosmos
|
2012
|
tom 61
|
nr 1
6

The modulation of iron regulatory protein 1 [IRP1] by nitric oxide [NO] in a pair of mouse lymphoma cell lines L5178Y displaying different control of iron metabolism

80%
Starzynski R. R., Drapier J. C., Kruszewski M., Lipinski P.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
7

A new SNP in the promoter region of the porcine MYF5 gene has no effect on its transcript level in m.longissimus dorsi

71%
Urbanski P., Flisikowski K., Starzynski R. R., Kuryl J., Kamyczek M.
Journal of Applied Genetics
|
2006
|
tom 47
|
nr 1
Myogenic factor 5 (myf-5) is the product of the MYF5 gene, belonging to the MyoD family. This transcription factor participates in the control of myogenesis. We identified 3 new mutations in the promoter region of the gene: A65C, C580T and C613T. The aim of this study was to evaluate the influence of the A65C transversion on gene expression. The analysis was conducted on 15 Polish Large White gilts. The relative content of MYF5 mRNA in m. longissimus dorsi did not differ significantly across MYF5 genotypes (AA, AC, CC). This result suggests that the A65C transversion may not play an important role in the expression of the MYF5 gene in analysed adult muscle but it abolishes a putative binding site for two transcription factors (CDP and HSF1) and creates such a site for Sp1.
8

Wplyw dekstranu zelaza na stezenie skladnikow mineralnych w watrobie nowo narodzonych prosiat

61%
Gralak M. A., Lipinski P., Starzynski R. R., Smuda E., Kuryl T., Debski B.
Medycyna Weterynaryjna
|
2007
|
tom 63
|
nr 11 Supl.
1500-1503
Piglets were euthanized on 1st, 4th, 7th, 14th, and 28th day of life. Iron dextran was injected intramuscularly (200 mg Fe/head) on the 4th day. The concentration of Fe, Ca, Mg, Mn, Zn, and Cu was estimated by flame atomic absorption spectrometry. The liver Fe concentration was 177 ± 49 mg Fe/kg on the 1st day, and this may be considered to be adequate. After injecting iron dextran, it increased nine-fold to 1594 ± 11 mg Fe/kg fresh liver, which was higher than the toxic level reviewed in literature for adult pigs (400 mg Fe/kg). The liver iron decreased to the first day level only on day 28. It was significantly correlated (r = 0.81) with the liver Mn concentration. Calcium in liver (25.0 ± 6.3 mg/kg) increased on day 7 (55.0 ± 2.7 mg/kg) and remained on the same level until the end of the experiment (55 mg/kg). No significant changes were observed in liver Mg content (about 200 mg/kg in average). Apart from the iron content, the most evident changes were stated in the liver Zn level which rapidly decreased from 99.0 ± 8.9 (1st day) to 19.2 -21.8 mg/kg (7-28 days). The liver Cu content remained unchanged for two weeks after birth (64.9-52.6 mg/kg), and only on day 28 had decreased three times as compared to the first day (21.2 ± 1.7 mg/kg). Generally, the liver Fe concentration increased to the toxic level after intramuscular injection of iron dextran (200 mg/head). Hence, it would be better for piglet health to apply iron dextran in two doses. It seems that there is a close correlation in the metabolism of iron and manganese in the liver. The liver concentration of other elements was not affected by iron injections. The Cu deposit in the liver is sufficient only for the first two weeks of life, which may be another risk factor of anaemia in piglets.
9

Niedokrwistosc u prosiat a tle niedoboru zelaza - nowe spojrzenie na stara patologie

51%
Lipinski P., Starzynski R. R., Gralak M. A., Smuda E., Olinski R., Tudek B., Dziaman T., Kowalczyk P., Usinska A., Zabielski R.
Przegląd Hodowlany
|
2007
|
tom 75
|
nr 11
23-26
10

Effect of iron supplementation on bone development in neonatal piglets

51%
Puzio I., Kapica M., Lipinski P., Valverde Piedra J. L., Starzynski R. R., Bienko M., Gralak M. A., Zabielski R.
Polish Journal of Natural Sciences. Supplement
|
2006
|
tom 03
353-359
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