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The Biolasol® liquid is an innovative solution used for perfusion, reperfusion and preservation of parenchymal organs of the abdominal cavity. Substances in the liquid prevent cellular oedema and help to maintain a proper water/mineral as well as acid/base balance in the intracellular environment. They also minimize free-radical injuries and ensure the integrity of the cellular membrane structure. The Biolasol® liquid has been shown to be much more efficient than the HTK liquid in the preservation of kidneys. The Biolasol® liquid containing 0.5 mM of vitamin C has been modified by adding ions of Se(IV), Zn(II), and their effect on the stability of the solution was examined. An accelerated aging test was applied to test the liquid stability. The test, based on the laws of chemical kinetics, was conducted at four temperatures at a 10°C step, that is: 50°C±0.05, 60°C±0.05, 70°C±0.05 and 80°C±0.05. The relative humidity equalled 75% of RH and the duartion of the test was 40 days. In order to determine the stability of the tested solutions, the Arrhenius Dependence equation was used, applied to the effect of temperature on the glucose decomposition reaction rate: lnk=lnA-(Ea/RT). The results indicate that the addition of zinc decreases the stability of the liquid by 30.5%, while the addition of selenium prolongs the stability by 8.21%. This is explained by the synergism of action of vitamin C and Se4+ antioxidant in the tested liquid. Zinc ions present in the solution increase the glucose decomposition reaction rate.
Spośród 203 policjantów, nadciśnienie tętnicze stwierdzono u 65 (32%). U 32 z nich, u których leczenie pojedynczym lekiem (perindopril 4 mg) by³o nieskuteczne, podano dodatkowo tlenek magnezu (MgO). Wydzielono z grupy chorych: ze stężeniem Mg w surowicy mniejszym od 1,0 mmol⋅dm-3 (NM) i większym lub równym 1,0 mmol⋅dm-3 (WM). Obie grupy nie różniły się między sobą wiekiem – 41,1±5,8 vs 39,3±6,2 lat, średnim ciśnieniem tętniczym (MAP) – 124,8±8 vs 123,6±7,4 mm Hg, wskaźnikiem masy ciała (BMI) – 28,20±8,2 vs 28,80±8,8 kg⋅m-2 i stężeniem sodu – 137,5±2,8 vs 136,6 ± 3 mmol⋅dm-3. Różniły się natomiast stężeniem: magnezu odpowiednio 0,790±0,1 vs 1,430±0,22 mmol⋅dm-3 (p<0,001), cholesterolu 7,5±0,4 vs 6,0±0,4 μmol⋅dm-3 (p<0,001), wapnia 2,340±0,12 vs 2,540±0,16 mmol⋅dm-3 (p<0,001) i potasu 4,380±0,32 vs 4,160±0,32 mmol⋅dm-3 (p=0,036). Po 30 dniach leczenia perindoprilem i MgO w obu grupach uzyskano znamienne obniżenie ciśnienia tętniczego o ok. 7%. Towarzyszyło mu obniżenie stężenia cholesterolu, znamienne statystycznie jedynie w grupie NM. W odróżnieniu od grupy NM, gdzie uzyskano wzrost stężenia magnezu o 21,5% (p<0,05), w grupie WM wystąpiło znamienne obniżenie stężenia tego pierwiastka w surowicy o 16,1% (p<0,05). Wniosek: Możliwe jest stosowanie u policjantów profilaktycznych dawek magnezu w połączeniu z lekami przeciw nadciśnieniowymi w celu wspomagania leczenia hipotensyjnego, obniżenia stężenia cholesterolu i wyrównywania zaburzeń gospodarki magnezowej, także u chorych z prawidłowymi stężeniami magnezu w surowicy.
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The purpose of this article is to research and retrieve patent information regarding the therapeutic use of truffles. Truffles have a unique value as a foodstuff and impact positively on human health and well-being. They are applied in such industries as the pharmaceutical industry and the cosmetic industry. Patent documentation available in the Espacenet network and the Patentscope service were analyzed by key word and patent specifications were examined to describe state of the art and to identify scientific research trends in therapeutic applications of truffles. Medicinal properties of truffles such as the anticancer or cardiovascular effect, a reduction in blood lipids, immunological resistance and increased energy were identified. Other therapeutic benefits include sedative action, prevention of hormonal imbalances in women, pre-menopause symptom relief, senile urethritis and prostate disorders, sleep disorders and increased absorption of calcium from milk. Truffles can also be used to alleviate symptoms of milk intolerance such as diarrhoea or bloating, to ease rheumatic pains and to treat and prevent further develop­ment or recurrence of senile cataract.
The effect of Biolactin-2 preparation, containing 5 mg of purified prolactin, on the occurrence of MMA syndrome and the number and weight of piglets in the litter was studied. The study was carried out on 212 gilts of which 150 were prophylactically administered Biolactin-2 preparation. Clinical examinations showed that MMA syndrome occured only in 7,33% of gilts in the group receiving Biolactin-2, while in the control group, it occured in 41,9%. Moreover, a higher body weight of the litter of 5.24 kg and larger litter size of 1.7 piglet, was ascertained at day 10 after birth amoung those given the preparation.
Iodine deficiency is a common phenomenon, threatening the whole global human population. Recommended daily intake of iodine is 150 μg for adults and 250 μg for pregnant and breastfeeding women. About 50% of human population can be at risk of moderate iodine deficiency. Due to this fact, increased iodine supplementation is recommended, through intake of iodized mineral water and salt iodization. The aim of this study was to investigate permeation and absorption of iodide from iodine bioplex (experimental group) in comparison with potassium iodide (controls). Permeation and absorption processes were investigated in vitro using a porcine intestine. The experimental model was based on a standard Franz diffusion cell (FD-Cell). The iodine bioplex was produced using Saccharomyces cerevisiae yeast and whey powder: iodine content - 388 μg/g, total protein - 28.5%, total fat - 0.9%., glutamic acid - 41.2%, asparaginic acid - 29.4%, lysine - 24.8%; purchased from: F.Z.N.P. Biochefa, Sosnowiec, Poland. Potassium iodide was used as controls, at 388 μg iodine concentration, which was the same as in iodine-enriched yeast bioplex. A statistically significant increase in iodide permeation was observed for iodine-enriched yeast bioplex in comparison with controls - potassium iodide. After 5h the total amount of permeated iodide from iodine-enriched yeast bioplex was 85%, which is ~ 2-fold higher than controls - 37%. Iodide absorption was by contrast statistically significantly higher in controls - 7.3%, in comparison with 4.5% in experimental group with iodine-enriched yeast bioplex. Presented results show that iodide permeation process dominates over absorption in case of iodine-enriched yeast bioplex.
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