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1

Kurkumina - od medycyny naturalnej do kliniki

100%
Wolanin K., Piwocka K.
Kosmos
|
2008
|
tom 57
|
nr 1-2
53-65
2

Rola i znaczenie surwiwiny w przebiegu mitozy

100%
Wolanin K., Piwocka K.
Postępy Biochemii
|
2007
|
tom 53
|
nr 1
10-18
3

Role of calcium-independent phospholipase A2 in the UV-induced apoptosis in Jurkat cells

71%
Zablocki K., Bielak A., Piwocka K., Wojtczak L., Duszynski J.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
4

Effect of aging on UVC-induced apoptosis of rat splenocytes

71%
Radziszewska E., Piwocka K., Bielak-Zmijewska A., Skierski J., Sikora E.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 2
UVC-induced apoptotic symptoms such as morphological changes, DNA fragmentation, Bcl-2 and Bax protein expression were examined in primary splenocyte cultures from young (3 months) and old (24 months) rats. The activities of AP-1 and CRE transcription factors in UVC-irradiated splenocytes were also assessed. At 24 h after UVC irradiation 40% of cells derived from young rats were found to be apoptotic, which was twice as much as in splenocytes from old rats. Apoptosis in cells from old rats did not give typical symptoms like a DNA ladder and Bcl-2 protein downregulation, in contrast to splenocytes from young rats. No AP-1 transcription factor activity was found in UVC-irradiated splenocytes from old animals and only a trace activity in splenocytes from young animals. This indicates that, UVC-induced apoptosis in rat splenocytes is practically AP-1 independent and that cells from old rats are less sensitive to UVC irradiation than splenocytes from young rats.
5

Aneuploidy and cancer; Bcr-Abl expression leads to compromised mitotic spindle checkpoint promoting chromosomal instability

61%
Piwocka K., Wolanin K., Magalska A., Vejda S., McKenna S.-L., Sikora E.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr Supplement 4
6
Content available remote

Ciprofloxacin inhibits proliferation and promotes generation of aneuploidy in Jurkat cells

61%
Koziel R., Szczepanowska J., Magalska A., Piwocka K., Duszynski J., Zablocki K.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 2
Ciprofloxacin is widely used in antimicrobial therapy. However it also inhibits mitochondrial topoisomerase II and therefore affects cellular energy metabolism. At a concentration exceeding 80 µg/ml ciprofloxacin induces apoptosis, while at 25 µg/ml it inhibits proliferation of Jurkat cells without any symptoms of cell death. The aim of this study was to explain the mechanisms of ciprofloxacin-evoked perturbations of the cell cycle. Human lymphoidal cells (Jurkat) were exposed to ciprofloxacin (25 µg/ml) for 4-11 days and effects of the drug on cell proliferation (light microscopy), cell cycle (flow cytometry), cell size and morphology (confocal microscopy) as well as number of chromosomes (chromosomal spread analysis) were investigated. Exposition of Jurkat cells to ciprofloxacin inhibited cell proliferation, increased proportion of cells in the G2/M-phase of the cell cycle, compromised formation of the mitotic spindle and induced aneuploidy. These observations indicate that ciprofloxacin applied at concentrations insufficient for induction of apoptosis may stop cell proliferation by inhibition of mitosis. Chromosomal instability of such cells may, at least potentially, increase a risk of cancer development.
7

Curcumin induces cell death without oligonucleosomal DNA fragmentation in quiescent and proliferating human CD8+ cells

61%
Magalska A., Brzezinska A., Bielak-Zmijewska A., Piwocka K., Mosieniak G., Sikora E.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr 3
8

Chemotherapeutics-treated cancer cells display stem-like and senescent cell features

42%
Was H., Czarnecka J., Barszcz K., Kowalczyk A., Bernas T., Uzarowska E., Koza P., Klejman A., Piwocka K., Sikora E., Kaminska B.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
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