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1

Interaction of adenosine and AT II agents on seizure threshold in mice

100%
Tchekalarova J., Georgiev V.
Acta Neurobiologiae Experimentalis
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1997
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tom 57
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nr 5
2

Effects of angiotensin II and its peptide 4nd nonpeptide receptor antagonists oh 4 writhing test

100%
Georgieva D., Georgiev V.
Acta Neurobiologiae Experimentalis
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1997
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tom 57
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nr 5
3

Effects of AT II and its receptor antagonists (peptide and non-peptide) on memory processes of rats

100%
Georgiev V., Kambourova T.
Acta Neurobiologiae Experimentalis
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1997
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tom 57
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nr 5
4

Alkaloids biosynthesis by Pancratium maritimum L. shoots in liquid culture

81%
Georgiev V., Ivanov I., Berkov S., Pavlov A.
Acta Physiologiae Plantarum
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2011
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tom 33
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nr 3
The process of alkaloid biosynthesis by Pancratium maritimum shoot culture, cultivated under submerged conditions, was investigated. Twenty-two compounds of different structural types of the Amaryllidaceae alkaloids (tyramine, narciclasine, galanthamine, haemanthamine, lycorine, pancracine, tazettine and homolycorine types) were detected in the studied samples from biomass and cultural liquid. Dominant compounds in the shoots were of tyramine, lycorine and haemanthamine types, whereas in the culture media were found mainly lycorine type compounds. Based on the multi-metabolic estimation of the alkaloid metabolism and physiological peculiarities, liquid cultures of P. maritimum shoots could be defined as prospective biological systems for producing bioactive molecules with acetylcholinesterase inhibitory and apoptotic activities.
5

Betalain production in plant in vitro systems

81%
Georgiev V., Ilieva M., Bley T., Pavlov A.
Acta Physiologiae Plantarum
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2008
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tom 30
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nr 5
Betalains have been widely used as natural colorants for many centuries, but their attractiveness for use as colorants of foods (or drugs and cosmetics) has increased recently due to their reportedly high anti-oxidative, free radical scavenging activities and concerns about the use of various synthetic alternatives. The main commercial sources of betalains are powders and concentrates of red beet (Beta vulgaris) or cactus pear (Opuntia ficusindica) extracts. However, in recent years the technical and commercial feasibility of various in vitro systems to produce them biotechnologically has been explored. These research activities have included assessments of novel approaches for cultivating plant cell or tissue cultures, and diverse bioreactor systems for increasing production levels of secondary metabolites. This paper reviews recent progress in plant in vitro systems for producing betalain pigments. In addition, the factors that could be manipulated, the bioreactor systems that could be used, and the strategies that could be applied to improve betalain production are discussed.
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