Wyniki wyszukiwania

1

The effect of phytoestrogen, genistein, on the hormonal and metabolic status of pregnant rats

100%

Nogowski L., Szkudelska K., Szkudelski T., Pruszynska-Oszmalek E.

Journal of Animal and Feed Sciences

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2006

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tom 15

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nr 2

275-286

Genistein, a plant-derived compound, is a phytoestrogen and has a quite well-documented effect on carbohydrate and lipid metabolism in animals. Data is lacking, however, about the influence of this compound when the level of endogenous oestrogens is high, for example in pregnancy. The aim of the performed experiment was to investigate the effect of dietary genistein (100 mg/kg of feed) on some blood hormone concentrations and metabolic parameters in pregnant rats. Two groups of pregnant Wistar rats were used: the animals in one group were fed a diet without genistein and in the other, a genistein-supplemented diet. Animals from both groups were sacrificed on day 13 or 18 of gestation or on the first day after delivery. Additionally, one group of control non-pregnant rats was fed a diet without genistein and used to compare with pregnant rats. The blood sera, livers and skeletal muscles of animals were collected and stored (-80 °C) until analysis. Genistein caused a substantial decrease of the serum leptin concentration on day 18 of gestation and of leptin and ACTH concentrations on the first day after delivery. The serum insulin, glucagon and corticosterone concentrations remained unaffected by genistein. The tested compound did not influence serum glucose, triglycerides, free fatty acids, cholesterol or liver and muscle glycogen, triglycerides and cholesterol. These results suggest that genistein, despite its well-described oestrogenic potency, can not manifest its action during pregnancy because of high levels of endogenous oestrogens.

2

The effect of genistein on some hormones and metabolic parameters in the immature, female rats

100%

Nogowski L., Nowicka E., Szkudelski T., Szkudelska K.

Journal of Animal and Feed Sciences

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2007

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tom 16

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nr 2

274-282

3

Resveratrol reduces excessive cholesterol accumulation in Goto-Kakizaki rat, a model with congenital type 2 diabetes

100%

Szkudelska K., Okulicz M., Szkudelski T.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 4

4

Genistein induced metabolic and hormonal changes in male rats

100%

Nowicka E., Szkudelska K., Szkudelski T., Nogowski L.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

5

The influence of genistein on insulin, leptin, thyroid hormones and metabolic parameters in mature rats

100%

Nowicka-Stanczyk E., Szkudelski T., Szkudelska K., Nogowski L.

Journal of Animal and Feed Sciences

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2012

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tom 21

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nr 1

Genistein is a phytoestrogen and is found in many plants consumed by humans and animals. This isoflavone was found to exert metabolic effects, especially on lipid and carbohydrate metabolism. The aim of this experiment was to determine whether genistein at a dose of 1 and 5 mg/kg body weight administered intragastrically to male and female adult rats changes insulin, leptin, thyroid hormone, and metabolic parameters. The results suggest that genistein has only a slight influence on metabolism. A substantial reduction of triglyceride stores was observed in the skeletal muscles. This effect was sex-dependent and occurred only in females. Moreover, it was demonstrated that genistein at the higher dose decreased blood insulin and leptin levels.

6

Inhibition of phosphodiesterase 3B in insulin-secreting cells of normal and streptozotocin-nicotinamide-induced diabetic rats: implications for insulin secretion

100%

Zywert A., Szkudelska K., Szkudelski T.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 3

7

Hormonal and metabolic effects of genistein and daidzein in male rat

76%

Szkudelska K., Nogowski L., Kaczmarek P., Pruszynska-Oszmalek E., Szkudelski R., Sieczka A., Szkudelski T.

Journal of Animal and Feed Sciences

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2003

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tom 12

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nr 4

839-847

8

Blood hormones, metabolic parameters and fatty acid proportion in dairy cows fed condensed tannins and oils blend

64%

Szczechowiak J., Szkudelska K., Szumacher-Strabel M., Sadkowski S., Gwozdz K., El-Sherbiny M., Kozlowska M., Rodriquez V., Cieslak A.

Annals of Animal Science

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2018

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tom 18

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nr 1

9

Mechanism of phytoestrogen action in reproductive processes of mammals and birds

51%

Dusza L., Ciereszko R., Skarzynski D. J., Nogowski L., Opalka M., Kaminska B., Nynca A., Kraszewska O., Slomczynska M., Woclawek-Potocka I., Korzekwa A., Pruszynska-Oszmalek E., Szkudelska K.

Reproductive Biology

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2006

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tom 06

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nr Suppl.1

Ograniczanie wyników

The effect of phytoestrogen, genistein, on the hormonal and metabolic status of pregnant rats

The effect of genistein on some hormones and metabolic parameters in the immature, female rats

Resveratrol reduces excessive cholesterol accumulation in Goto-Kakizaki rat, a model with congenital type 2 diabetes

Genistein induced metabolic and hormonal changes in male rats

The influence of genistein on insulin, leptin, thyroid hormones and metabolic parameters in mature rats

Inhibition of phosphodiesterase 3B in insulin-secreting cells of normal and streptozotocin-nicotinamide-induced diabetic rats: implications for insulin secretion

Hormonal and metabolic effects of genistein and daidzein in male rat

Blood hormones, metabolic parameters and fatty acid proportion in dairy cows fed condensed tannins and oils blend

Mechanism of phytoestrogen action in reproductive processes of mammals and birds