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The author reviews the course of interests in the field of trichomonadosis in Poland presenting a number of suggestions to combat the disease.
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On the role of infections of Trichomonas vaginalis in man attention was turned in Poland already in 1928. Works published before 1939 and after the last war on trichomoniases in man included the problems of clinical, microscopical, cultivation and serological diagnosis of the diseaise and observations of the therapeutic effect of various methods of its treatment. As regards trichomoniasis of animals wider studies were undertaken not until after the last war. Presently particular atention is paid to infections of cows and bulls with Trichomonas foetus and to the methods of detection, treatnient and combating the disease. The problem of eventual mutual relation between the occurrence of the trichomonas in the alimentary tract of pigs and trichomonadiosis of cattle is studied (Stępkowski and cowork).
Nystersol was examined for its efficiency in the treatment of inflammatory conditions of the vagina induced by T. vaginalis. The examinations were made with 3 strains in vitro and the treatment with the drug was instituted in 38 patients (including 8 girls) in whom clinical and laboratory examinations showed trichomonal vaginitis. The in vitro examinations reveated that Nystersol when given in high concentr ations (12.5, 5.0%) exerts a destroying action on T. vaginalis as early as after 1 hour. With these concentrations, no motile protozoa were found after 8-9 and more hours. In 38 patients treated with this drug, a tendency to disappear or total regressian of clinical symptoms could be observed already during the treatment. Nystersol was found to have a deleterious effect on the vaginal bacterial flora which promotes the T. vaginalis infection. The follow-up examinations performed 38 and 72 days after the completion of the1 therapy showed the presence of the parasite in the vaginal discharge of 14 patients, but the vaginal cleanliness as evaluated according to Jirovec, Peter and Malek was shifted towards more positive groups and subgroups. In the authors' opinion the therapeutic failure in these patients is accounted for by repeated superinfection from various sources (sexual partners, family, penetration of the parasite from the urinary tract) which could not be brought under control. No side effects of the drug were seen. The authors advocate clinical studies on the combined treatment of trichomonadosis with Nystersol and a drug with generał action.
The authors examined 121 patients males with an effluvium from the urethra. They found in 66.1% of the cases a not-gonorrhoeal inflammation of the urethra. In 6.6% of all the cases of the inflammation of the urethra and 10% of the not-gonorrhoeal inflammations of the urethra were caused by Trichomonas vaginalis. In 1.7% of the cases of the total number of men with an effluvium from the urethra there coexisted the infection with diplococcus of Neisser and Trichomonas vaginalis.
The authors compared the reaction in 114 women caused by toxoplasmine produced by the Parasitological Department of the "Universita Karlova'' in Prague and that one produced by the Parasitological Department of the Institute of Labour Medicine and Rural Hygiene in Lublin. At an equal dilution of antigens (1 : 1000) the first toxoplasmine induces more frequent and violent skin reactions. Some differences, which could not be nearer explained, were also observed when applying various dilutions. An exact standardization of the antigens aind diagnostic methods for toxoplasmosis should be introduced in order to be able to compare different results.
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