Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 12

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

XLIII Winter School of the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland: "Biomolecules: from structure to function"

100%
Kasza A.
Acta Biochimica Polonica
|
2016
|
tom 63
|
nr 3
2

The activity and function of MCPIP2 - the most enigmatic member of the ZC3H12 family of proteins

63%
Wawro M., Kasza A.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
3

Mozliwosci terapeutycznego zastosowania modyfikowanych, syntetycznych i otrzymanych w drodze rekombinacji inhibitorow proteinaz serynowych

63%
Kasza A., Laczka A.
Postępy Biologii Komórki. Suplement
|
1994
|
tom 3
143-156
4

Regulacja ekspresji genu PAI-1

63%
Wyrzykowska P., Kasza A.
Postępy Biochemii
|
2009
|
tom 55
|
nr 1
5
Content available remote

Cytokines regulate plasminogen activation system in astrocytoma cells

63%
Kasza A., Koj A.
Journal of Physiology and Pharmacology
|
2002
|
tom 53
|
nr 1
We report here that human astrocytoma cell line U373-MG is able to express genes of the following components of plasminogen activation system:PAI-1,PN-1,u-PA and t-PA. Treatment of these cells with IL-1 ß results in accumulation of PAI-1,PN-1 and u-PA mRNAs,whereas t-PA mRNA remains unaffected.IFN preferentially enhances PN-1 and PAI-1,EGF enhances PAI-1,u-PA and t-PA expression.Simultaneous addition of anti-inflammatory cytokines IL-4,IL-13 and IL-10 has little effect on the tested components,except induction of u-PA mRNA wich was further enhanced by IL-4.We have confirmed interesting time-dependent regulation of plasminogen activation system by EGF/IFN .Cells stimulated with EGF/IFN show at first increased proteolytic activity but after 24 h inhibition of proteolysis with PAI-1 would prevail.To understand the co- operative effect of EGF and IFN in PAI-1 induction the kinetics of activation of STAT1 was studied.It was found that although EGF alone does not activate STAT1,the STAT1 binding activity in the cells treated with the mixture of EGF/IFN was considerably prolonged.Our results indicate the importance of inflammatory cytokines and EGF in gene regulation of plasminogen activation system in astrocytoma cells.
6

Degradacja transkryptorów eukariotycznych. Funkcja i regulacja tristetraproliny

51%
Balwierz A. K., Tymoszuk P., Kasza A.
Postępy Biochemii
|
2009
|
tom 55
|
nr 3
7

CRISPR/Cas9 and Sleeping Beauty System - novel tools for genome editing

51%
Sowinska W., Wawro M., Solecka A., Kasza A.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
8

Potential limitations of the Sleeping Beauty transposon use in gene expression studies

51%
Sowinska W., Wawro M., Solecka A., Kasza A.
Acta Biochimica Polonica
|
2019
|
tom 66
|
nr 3
9

The perplexities of the ZC3H12A self - mRNA regulation

51%
Wawro M., Kochan J., Kasza A.
Acta Biochimica Polonica
|
2016
|
tom 63
|
nr 3
10

Biosythesis and distibution of leucocyte elastase inhibitor. Production of recombinant in inhibitor

51%
Kasza A., Korpula-Mastalerz R., Rose-John S., Dubin A.
Acta Biochimica Polonica
|
1996
|
tom 43
|
nr 3
The horse leucocyte elastase inhibitor (HLEI), present in neutrophils, monecytes and bone marrow cells, is apparently a cytoplasmic protein which is not released from cells even in response to stimulation with lipopolysaccharide, phorbol ester, tumour necrosis factor alpha, interleukin-1 or elastin degradation products. Although no expression of the inhibitor was detected in neutrophils, both monocytes and bone marrow cells were efficient in its synthesis. Using a new expression vector pREST5d, recombinant inhibitor was produced in a large quantity in a soluble form, with a yield of 88 mg per 10 litres of E. colt culture. A two-step purification procedure, consisting of ion-exchange chromatography and gel filtration, yielded 36 mg of the recombinant inhibitor of a purity higher than 95%, as judged by SDS/PAGE. The recombinant protein had physicochemical and kinetic properties indistinguishable from those of the natural one, including irreversible elastase inhibition with an association rate constant kass > 10 7 M -1 s -1. Both proteins were eliminated from rat circulation at the same ratio, and within the first 20 min 70% of the protein was removed. Such a short half-life in the circulation suggests that local delivery of HLEI directly to lungs in the form of aerosol could be a more efficient therapeutic approach than its intravenous injection.
11

The influence of metabolism on the phenotype of astrocytoma U-251 MG cell line

45%
Solecka A., Wielento A., Wawro M., Sowinska W., Kasza A.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
12

Influence of the reporter vector backbone on 2-deoxyglucose dependent promoter activation

39%
Solecka A., Wielento A., Jurczak J., Sowinska W., Wawro M., Kasza A.
Acta Biochimica Polonica
|
2020
|
tom 67
|
nr 3
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.