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The influence of feed phosphates on the structural, mechanical and chemical properties of bone tissue in pigs

100%

Nikodem A., Dragan S., Kolacz S., Dobrzanski Z.

Polish Journal of Veterinary Sciences

2012

tom 15

nr 2

The aim of the study was to assess the influence of various feed phosphates on the structural and mechanical properties as well as on the chemical composition of femurs in adult pigs (weight approx. 110 kg). Three types of phosphates - monocalcium phosphate (MCP), dicalcium phosphate (n-DCP) and calcium-sodium phosphate (CSP) - were used alternatively in pigs fed with the standard feed mixture. The MCP and CSP phosphates were typical, imported products used traditionally in pig feeding. Dicalcium phosphate (n-DCP) was manufactured in Poland on the basis of phosphoric acid with the new pro-ecological method. The following parameters were determined: the mean physical density of the samples of the compact and spongy bone tissue, values of Young's modulus, strength and the energy of deformation, and Vickers microhardness (HV). Also the content of C, O, Na, Mg, Al, and Si, as well as Ca, P and Sr was determined. Significant differences in mean values of the mentioned parameters occurred between the studied groups. The best mechanical properties were shown by the bones from the n-DCP group, and the compact bone tissue (diaphysis) contained the most Ca, P, and Sr when compared to the MCP and CSP groups.

The experimental osteoporosis in sheep - clinical approach

64%

Kielbowicz Z., Piatek A., Biezynski J., Skrzypczak P., Kuropka P., Kuryszko J., Nikodem A., Kafarski P., Pezowicz C.

Polish Journal of Veterinary Sciences

2015

tom 18

nr 3

The implementation of new methods of oseoporotic therapy requires tests on an animal model. One of the best is the sheep, whose numerous advantages over other models are described in the literature. The aim of this study was induction of osteoporosis using steroids and ovariorectomy methods in sheep and description of the change in parameters with regard to healthy sheep. The study was performed on female „merino” breed sheep divided into three groups: Negative control (NC) healthy animals, positive control (PC) ovariorectomised animals and steroid group (SC) where methylprednisolone was implemented. Blood tests, diagnostic arthroscopy, quantitative computed tomography and X-Ray micro-tomography of bone were carried out. Blood tests revealed a decreased level of estrogens, progesterone and increased parathormone and cortisol levels in the SC group. A decrease in bone turnover markers and an increase in bone resorption markers in all groups were also noted. Diagnostic arthroscopy revealed osteoarthrosis in PC and SC groups. Radiological density tests showed a slight decrease in PC and NC groups whereas there was more than a triple decrease in SC. Results obtained from microCT showed quickly developing osteoporosis in the SC group, which is reflected in numerous parameters analysed in this study. The best effects for osteoporosis induction were obtained using ovariorectomised sheep with methylprednisolone injections.

Experimental osteoporosis in sheep - mechanical and histological approach

64%

Kielbowicz Z., Piatek A., Kuropka P., Mytnik E., Nikodem A., Biezynski J., Skrzypczak P., Pezowicz C., Kuryszko J., Reichert P.

Polish Journal of Veterinary Sciences

2016

tom 19

nr 1

The implementation of new methods of osteoporotic therapy requires tests on animal model. The use of sheep as model has numerous advantages over other animals. The aim of this study was to describe the change in parameters in sheep with osteoporosis induced using steroids and ovariorectomy methods as opposed to the parameters in healthy sheep. The study was performed on female „merinos” breed sheep divided into the three groups: negative control (NC) – healthy animals, positive control (PC) – ovariorectomized animals and steroid control group (SC) – in which methylprednisolone was administered. This paper presents histological and ultrastructural examination with mechanical comparative tests for force/strength values as well as indentation tests of joint cartilage. The obtained results confirm the loss of bone mass associated with mineral composition content in bones, which has an influence on bone strength.

Ograniczanie wyników

3 Polish Journal of Veterinary Sciences

3 Nikodem A.

2 Biezynski J.

2 Kielbowicz Z.

2 Kuropka P.

2 Kuryszko J.

2 Pezowicz C.

2 Piatek A.

2 Skrzypczak P.

1 Dobrzanski Z.

1 Dragan S.

1 Kafarski P.

1 Kolacz S.

1 Mytnik E.

1 Reichert P.

1 2016

1 2015

1 2012

Wyniki wyszukiwania

The influence of feed phosphates on the structural, mechanical and chemical properties of bone tissue in pigs

The experimental osteoporosis in sheep - clinical approach

Experimental osteoporosis in sheep - mechanical and histological approach