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The effects of prenatal exposure to methylxanthines

100%

Skopinski P., Woronkowicz M., Skopinska-Rozewska E., Siwicki A. K.

Polish Journal of Veterinary Sciences

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2011

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tom 14

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nr 4

This review discusses epidemiology and laboratory studies on the effects of prenatal methylxanthine administration on some systems developing organisms. They are mainly absorbed from coffee, tea and cocoa products such as cola beverages and chocolate bars. Prenatal methylxanthine exposure can induce several unfavourables changes in the developing organism, which are persistent even in later phases of life. Based on results obtained from animal studies, the effect on embryogenesis is not only poorly understood but also controversial. It is therefore important to study interspecies differences as results may differ depending on animals used and administration methods.

2

Biological effects of conjugated linoleic acids supplementation

100%

Oleszczuk J., Oleszczuk L., Siwicki A. K., Skopinska-Rozewska E.

Polish Journal of Veterinary Sciences

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2012

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tom 15

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nr 2

Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids (PUFA) with a single pair of conjugated double bonds. The major natural CLA isomer is 18:2 cis-9, trans-11 (c9, t11) linoleic acid, or rumenic acid (RA). Chemically synthesized CLA is also available, mostly as a mixture of RA and 18:2 trans-10, cis-12 (t10, c12) isomers in equal amounts (50:50). Consumption of ruminant meat (beef and lamb) and dairy products (milk and cheese) is the main source of dietary exposure to CLA. Despite numerous studies on animal and human models (tumorigenesis, obesity, immune response) it has not been established whether additional supplementation of CLA is of benefit. Moreover, some studies, conducted both in animals and in humans, reveal that CLA isomers may induce insulin resistance. Presently, balanced diet rich in CLA from natural sources is recommended. The purpose of this review was to sum up the results available in the literature.

3

Rhodiola rosea in vitro culture - phytochemical analysis and antioxidant action

100%

Furmanowa M., Skopinska-Rozewska E., Rogala E., Hartwich M.

Acta Societatis Botanicorum Poloniae

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1998

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tom 67

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nr 1

4

Teophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition

100%

Chorostowska-Wynimko J., Kus J., Skopinska-Rozewska E.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

5

Certain characteristics of human lymphocyte migration inhibitory of ampicillin on their apperance in unstimulated and PHA-stimulated cultures

100%

Skopinska-Rozewska E., Madalinski W., Lukasik R.

Acta Physiologica Polonica

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1983

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tom 34

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nr 3

6

The effect of herbal remedy on the development of Trichinella spiralis infection in mice

100%

Bany J., Zdanowska D., Zdanowski R., Skopinska-Rozewska E.

Polish Journal of Veterinary Sciences

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2003

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tom 06

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nr 3 Suppl.

7

Feeding pregnant and lactating mice Rhodiola kirilowii extracts helps to preserve thymus function of their adult progeny

88%

Bien K., Lewicki S., Zdanowski R., Skopinska-Rozewska E., Krzyzowska M.

Polish Journal of Veterinary Sciences

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2016

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tom 19

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nr 3

Plants belonging to Rhodiola kirilowii species, members of Rhodiola genus and Crassulaceae family, grow wildly in Tibet, Mongolia and China mountains and are traditionally used as adaptogens, antidepressants and anti-inflammatory remedies. Nowadays, R. kirilowii is cultivated in some countries, also in Poland. In our previous papers we reported immuno- and angio-modulatory effects of aqueous and hydro-alcoholic extracts of radix and rhizome of this plant in non-pregnant and pregnant mice. The aim of the present study was to evaluate the effect of feeding pregnant and further lactating mice these extracts on selected thymus function parameters in adult progeny. The counts of M-30+ apoptotic cells, in the thymuses obtained from progeny of mice fed during pregnancy and lactation water or 50% water-alcoholic extract of Rhodiola kirilowii, were significantly lower (p<0.05) than apoptotic cells counts observed in the control mice. No significant differences in the counts of IL-7-positive cells in the thymuses obtained from progeny of the control mice and mothers treated with water or hydro-alcohol extracts of Rhodiola kirilowii were observed.

8

Ampicillin effect on lymphatic tissue of mice and its reaction to sheep erythrocytes

88%

Moscicka-Wesolowska M., Skopinska-Rozewska E., Morzycka-Michalik M., Mioduszewska O., Nowicka E.

Acta Physiologica Polonica

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1983

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tom 34

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nr 3

9

The natural killer cells (NK) of human neonatal lymphocytes

88%

Gawrychowski K., Majewski S., Skopinska-Rozewska E., Kaminski P., Marianowski L.

Archivum Immunologiae et Therapiae Experimentalis

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1990

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tom 38

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nr 1-2

10

Lymphocyte mitogen-induced proliferation in patients with allergic rhinitis

88%

Chorostowska-Wynimko J., Kleniewska D., Sokolnicka I., Rogala E., Skopinska-Rozewska E.

Archivum Immunologiae et Therapiae Experimentalis

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1995

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tom 43

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nr 3-4

11

Przeciwciała przeciwjądrowe (ANA) i przeciwko cytoplazmie granulocytów obojętnochłonnych (ANCA) u chorych na mukowiscydozę

76%

Demkow U., Filewska M., Skorupa W., Kus J., Wiatr E., Skopinska-Rozewska E.

Diagnostyka Laboratoryjna

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2004

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tom 40

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nr 3

12

Aktywnosc immunotropowa wyciagow roslinnych. II. Wplyw wyciagow wodnych z lisci i paczkow topoli na migracje leukocytow in vitro

76%

Malkowska-Zwierz W., Glinkowska G., Rogala E., Strzelecka H., Sikorska E., Skopinska-Rozewska E.

Herba Polonica

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1995

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tom 41

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nr 2

80-83

The effect of water extracts from folium and bud poplar on migration of peripheral blood granulocytes and lymphocytes from healthy donors were examined. We observed strong suppresive effect of folium extract and no influence of bud extract on lymphocytes migration. We suppose that this difference depends on presence of gentisic acid in bud extract. Although we observed suppressive effect of both extracts (stronger for bud) on human granulocytes migration. This effect appeared only in highest concentrations.

13

Effects of homogenization of induced sputum by dithiothreitol on polymorphonuclear cells

76%

Van Overveld F. J., Demkow U., Gorecka D., Skopinska-Rozewska E., De Backer W. A., Zielinski J.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

143-154

Induced sputum represents a useful and non-invasive tool to isolate different cells from the airways. Complete homogenization of sputum is important for dispersion of cells and is usually achieved by use of dithiothreitol (DTT). However, it is not known if DTT will influence the viability and functionality of cells obtained by induced sputum. In the present study, induced sputum was processed by DTT or by PBS treatment. The obtained neutrophils were compared with neutrophils obtained from peripheral blood and from bronchoalveolar lavage fluid (BAL). These isolated neutrophils were treated in a similar way as the sputum neutrophils with DTT or PBS. All isolated cells were used for chemiluminescence tests and for the measurement of elastase and myeloperoxidase release after stimulation with fMLP. The results showed that the maximum chemiluminescence response was always significantly lower after DTT treatment: blood, 16.68 ±1.89 vs. 2.62 ±0.43 mV, P<0.0001; sputum, 2.96 ±0.30 vs. 1.09 ±0.01 mV, P<0.01; BAL, 25.47 ±0.88 vs. 8.22±0.20 mV, P<0.0001. Both spontaneous and fMLP-induced release of elastase and myeloperoxidase (MPO) was in most cases enhanced after DTT-treatment (P-values range from 0.24 to <0.01). We conclude that the use of DTT to homogenize sputum for dispersion of cells is harmful to cell functions and these cells are hampered for the evaluation of their normal functional characteristics.

14

In vivo stimulatory effect of multi-component herbal remedy PADMA 28 on mitogen-induced proliferation of mice splenic lymphocytes and their chemokinetic activity

76%

Skopinski P., Radomska-Lesniewska D. M., Sokolnicka I., Balan B. J., Siwicki A. K., Skopinska-Rozewska E.

Polish Journal of Veterinary Sciences

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2013

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tom 16

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nr 4

PADMA 28, a natural herbal multi-compound remedy originates from traditional Tibetan medicine and possesses a variety of beneficial effects on experimental and clinical models of inflammation and atherosclerosis, as well as angioprotecive, antioxidative and wound – healing properties. The aim of the present study was to evaluate the in vivo influence of this remedy on the in vitro mitogen-induced proliferation of murine splenic lymphocytes and their chemokinetic activity in cell culture.The study was performed on 6-8 weeks old inbred Balb/c mice. PADMA28 was administered to mice per os in daily doses 5.8 mg (calculated from the highest dose recommended for human) or 0.085 mg (dose from the range of active doses of other herbal extracts containing polyphenolic substances used previously by us in experiments with mice), for 7 days. Control groups received water. Results: No substantial differences were observed between groups of mice fed with low and high PADMA doses. In both of them, response of splenic lymphocztes to mitogen PHA (p < 0.001) and their in vitro chemokinetic activity (p < 0.001 for low dose and p < 0.01 for high dose) were highly significantly increased as compared to the controls. Conclusion: The results of our investigations suggest that PADMA 28 can stimulate cell-mediated immunity in mice and might be used for this purpose in the wide spectrum of doses.

15

Echinacea purpurea stimulates cellular immunity and anti-bacterial defence independently of the strain of mice

76%

Bany J., Siwicki A. K., Zdanowska D., Sokolnicka I., Skopinska-Rozewska E., Kowalczyk M.

Polish Journal of Veterinary Sciences

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2003

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tom 06

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nr 3 Suppl.

16

Influence of Echinacea purpurea intake during pregnancy on fetal growth and tissue angiogenic activity

76%

Barcz E., Sommer E., Nartowska J., Balan B. J., Chorostowska-Wynimko J., Skopinska-Rozewska E.

Folia Histochemica et Cytobiologica. Supplement

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2007

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tom 45

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nr 1

35-39

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In vivo immuno - and angiomodulatory effects of Aloe arborescens folii recentis extractum siccum (AAES) in mice

76%

Zdanowski R., Balan B. J., Schonknecht K., Skopinski P., Stelmasiak M., Skopinska-Rozewska E., Lewicki S.

Herba Polonica

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2020

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tom 66

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nr 3

18

Morphometric abnormalities in the spleen of the progeny of mice fed epigallocatechin during gestation and nursing

76%

Balan B. J., Skopinska-Rozewska E., Skopinski P., Zdanowski R., Lesniak M., Kiepura A., Lewicki S.

Polish Journal of Veterinary Sciences

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2017

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tom 20

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nr 1

It is very difficult to cure pregnant females suffering from infections, because of the risk which might occur during treatment by several, even herbal, medications. Many of these substances, among them extracts from plants, have antimicrobial, anti-inflammatory and immunostimulatory properties owing to their polyphenols content, but also may reveal unwanted effects on the fetal development because of their anti-angiogenic properties. The aim of the present study was to elucidate whether daily feeding pregnant and nursing mice 0.2 mg/kg epigallocatechin (EGC), previously recognized as angiogenesis inhibitor, may lead to abnormalities in morphology of spleen and in some parameters of immune function of their adult, 6-week old progeny. Morphometry of EGC offspring spleens revealed lower number of lymphatic nodules and their larger diameter than those found in the control offspring. Cellularity of spleens was lower in EGC offspring than in the controls. Cytometric analysis showed that this decline concerns lymphocytes with CD335 (p<0.001), CD19 (p<0.01) and CD4 (p<0.05) markers. No differences were observed in the humoral response to the immunization with SRBC, and in the proliferative response of splenocytes to mitogens PHA, ConA and LPS.

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In vivo inhibitory effect of Aloe vera gel on the ability of mouse parental splenic lymphocytes to induce cutaneous angiogenesis in recipient F1 mice

76%

Skopinski P., Lewicki S., Balan B. J., Kocik J., Zdanowski R., Skopinska-Rozewska E., Siwicki A. K.

Polish Journal of Veterinary Sciences

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2014

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tom 17

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nr 1

Lymphocyte-induced angiogenesis test (LIA) is a model of local graft-versus-host (GVH) reaction, marker of the earliest events resulting from activation of donor lymphocytes after contact with host semi-allogeneic histocompatibility antigens. The effect of in vivo oral administration of Aloe vera gel for 21 days to maternal strain (Balb/c) donor mice on the ability of their splenic lymphocytes to induce cutaneous angiogenesis (LIA test) in F1 Balb/c x C3H recipients, was studied. Results: Neovascular reaction evaluated 72 hours after cells grafting was significantly lower in F1 mice grafted with lymphocytes collected from Aloe- fed donors, than in recipients of lymphocytes collected from respective controls. Conclusions: This observation opens the promise of safe and ethically acceptable possibility of use of Aloe vera gel in human donors in prevention of GVHD in recipients of bone marrow grafts.

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Effect of extracts of St. John's wort (Hypericum perforatum L.) and lemon balm (Melissa officinalis L.) herbs on local GvH reaction and production of anti-SRBC antibodies

76%

Skopinska-Rozewska E., Rzadkowska-Bodalska H., Olechnowicz-Stepien W., Zukowska M., Malkowska-Zwierz W., Radomska D., Sobczynska A.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1991

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tom 39

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nr 3

Ograniczanie wyników

The effects of prenatal exposure to methylxanthines

Biological effects of conjugated linoleic acids supplementation

Rhodiola rosea in vitro culture - phytochemical analysis and antioxidant action

Teophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition

Certain characteristics of human lymphocyte migration inhibitory of ampicillin on their apperance in unstimulated and PHA-stimulated cultures

The effect of herbal remedy on the development of Trichinella spiralis infection in mice

Feeding pregnant and lactating mice Rhodiola kirilowii extracts helps to preserve thymus function of their adult progeny

Ampicillin effect on lymphatic tissue of mice and its reaction to sheep erythrocytes

The natural killer cells (NK) of human neonatal lymphocytes