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Tumor necrosis factor-alpha as a possible auto-/paracrine factor affecting estrous cycle in the cat uterus

100%

Siemieniuch M. J., Ogrodowska K., Ohgawara H., Skarzynski D. J., Okuda K.

Polish Journal of Veterinary Sciences

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2010

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tom 13

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nr 4

Tumor Necrosis Factor-alpha (TNFα) is a pleiotrophic cytokine, affects either normal or tumor cells, and influences cellular differentiation. TNFα role in female reproduction has been proven to be mediated through an influence on prostaglandin (PGs) synthesis and output. To evaluate the possible role of TNFα in an auto-/paracrine regulation in the cat uterus, mRNA expression coding for TNFα and its receptors (TNFR1 and TNFR2), and TNFα protein content at different stages of the estrous cycle were investigated. Additionally, TNFα involvement in PG secretion at different stages of the estrous cycle was investigated by in vitro tissue culture. Gene expressions coding for TNFα and TNFR1 were the highest at diestrus (P < 0.05). TNFα protein expression was the lowest at interestrus (P < 0.05). Nevertheless, TNFR2 was not affected by the estrous stage. TNFα at a dose of 1 ng/ml significantly increased PGF₂α secretion at estrus (P < 0.01) and PGE₂ secretion at diestrus (P < 0.001) after 12h incubation. Overall findings indicate that TNFα locally produced in the cat’s uterus, stimulates PG secretion in an estrous cycle-related manner.

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Are glucocorticoids auto– and/or paracrine factors in early bovine embryo development and implantation?

86%

Skarzynski D. J., Siemieniuch M. J., Majewska M., Takahashi M., Sakatani M., Lukasik K., Okuda K.

Reproductive Biology

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2010

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tom 10

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nr 3

3

The influence of tumor necrosis factor alfa (TNF) on the secretory function of bovine corpus luteum: TNF and its receptors expression during the estrous cycle

86%

Korzekwa A., Murakami S., Woclawek-Potocka I., Bah M. M., Okuda K., Skarzynski D. J.

Reproductive Biology

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2008

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tom 08

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nr 3

4

Fas-mediated apoptosis is suppressed by calf serum in cultured bovine luteal cells

72%

Skarzynski D. J., Shibaya M., Tasaki Y., Korzekwa A., Murakami S., Woclawek-Potocka I., Majewska M., Okuda K.

Reproductive Biology

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2007

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tom 07

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nr 1

Ograniczanie wyników

3 Reproductive Biology

1 Polish Journal of Veterinary Sciences

4 Okuda K.

4 Skarzynski D. J.

2 Korzekwa A.

2 Majewska M.

2 Murakami S.

2 Siemieniuch M. J.

2 Woclawek-Potocka I.

1 Bah M. M.

1 Lukasik K.

1 Ogrodowska K.

1 Ohgawara H.

1 Sakatani M.

1 Shibaya M.

1 Takahashi M.

1 Tasaki Y.

2 2010

1 2008

1 2007

Tumor necrosis factor-alpha as a possible auto-/paracrine factor affecting estrous cycle in the cat uterus

Are glucocorticoids auto– and/or paracrine factors in early bovine embryo development and implantation?

The influence of tumor necrosis factor alfa (TNF) on the secretory function of bovine corpus luteum: TNF and its receptors expression during the estrous cycle

Fas-mediated apoptosis is suppressed by calf serum in cultured bovine luteal cells