Exposure of an animal to stressful stimuli elicits a transient decrease in pain sensitivity, which often affects thermoregulatory mechanisms in the threatened organism. Briefly, we found that stress-induced analgesia (SIA) is inversely related to PMR (peak metabolic rate) and thermogenic capacity. This relationship was strong enough to permit the claim of an existence of a negative genetic correlation between SIA and PMR as well as thermogenesis. In the present study we performed a genome-wide quantitative trait locus (QTL) analysis in our mouse model established from outbred parental lines divergently selected for 60 generations for high- (HA line) or low- (LA line) swim stress-induced analgesia (SSIA) elicited by 3-min swim in 20°C water. The F2 population of 267 mice was used for the QTL analysis with 40 microsatellite markers distributed across the first five chromosomes. The analysis revealed significant QTLs SIA, for peak metabolism rate (PMR) and for hypothermia (Hyp). Some of these QTLs map to regions of known gene mutations influencing SIA, PMR and Hyp traits, moreover they map to regions of previously described QTLs and candidate genes. Apart from QTLs affecting single traits we identified QTLs common for examined traits (SIA-PMR-Hyp), (SIA-PMR), (SIA-Hyp) and (PMR-SIA) parameters, which explain phenotypic correlations between these traits.
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