Wyniki wyszukiwania

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Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line

100%

Przygodzki T., Slominska E., Polakowska E., Mlynarski W., Watala C.

Acta Biochimica Polonica

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2011

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tom 58

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nr 1

1-methylnicotinamide (MNA) is a primary metabolite of nicotinamide. In recent years several activities of MNA have been described, such as anti-inflammatory activity in skin diseases, induction of prostacyclin synthesis via COX-2, aortal endothelium protection in diabetes and hypertriglyceridaemia and increased survival rate of diabetic rats. 1-methylnicotinamide was also suggested to protect pancreatic cells from streptozotocin in vivo. Streptozotocin toxicity is known to be mediated by poly-ADP-ribose polymerase. Nicotinamide and its derivatives have been shown to ameliorate poly-ADP-ribose polymerase-dependent nucleotide pool reduction. We aimed to verify if 1-methylnicotinamide and its metabolite, N-methyl-2-pyridone-5-carboxamide, can protect insulinoma cells from streptozotocin-induced toxicity. We found that N-methyl-2-pyridone-5-carboxamide, but not 1-methylnicotinamide, restores the pool of ATP and NAD+ in streptozotocin-treated cells, but neither compound improved the cell viability. We conclude that inhibition of poly-ADP-ribose polymerase-dependent nucleotide pool reduction may not be sufficient to protect cells from streptozotocin toxicity.

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Czy mutacja genu AMPD1, kodujacego izoenzym miesniowy deaminazy AMP u czlowieka, moze byc markerem prognostycznym pierwotnej kardiomiopatii rozstrzeniowej?

100%

Kaletha K., Chodorowski Z., Nagel-Starczynowska G., Gazda M., Slominska E.

Postępy Biochemii

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1999

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tom 45

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nr 3

182-184

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Decrease in daily urine excretion nad metabolites in patients with chronic renal failure

86%

Slominska E., Bury K., Adamski P., Smolenski R., Rutkowski P., Swierczynski J.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

4

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Thermophysical and chemical properties of perennial energy crops depending on harvest period

86%

Stolarski M. J., Krzyzaniak M., Snieg M., Slominska E., Piorkowski M., Filipkowski R.

International Agrophysics

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2014

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tom 28

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nr 2

This paper presents analyses of the thermophysical and chemical properties of eleven perennial crop species harvested in one-year rotation cycles. The crops included four species grown for biomass in the form of straw, five species producing semi-wood biomass, and two species yielding wood biomass. The research comprised three consecutive crop harvests. In each harvesting season, biomass samples for analyses were taken on six dates at one-month intervals. Thermophysical and chemical properties of the biomass were significantly differentiated within the main experimental factors and their interactions. The biomass produced by Virginia mallow had the best quality parameters as solid fuel. In fact, it achieved the lowest water content and the highest lower heating value during all of the analyzed seasons and harvest dates. The biomass of the species yielding straw or semi-wood products attained better quality as solid fuel on later harvest dates. In turn, the quality of willow biomass remained practically unchanged between the harvest dates.

5

Differences in adenine incorporation between human and rat heart endothelium

86%

Kalsi K. K., Zych M., Slominska E., Kochan Z., Yacoub M. H., Smolenski R. T.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Cellular and Molecular Biology Letters

1 International Agrophysics

1 Postępy Biochemii

5 Slominska E.

1 Adamski P.

1 Bury K.

1 Chodorowski Z.

1 Filipkowski R.

1 Gazda M.

1 Kaletha K.

1 Kalsi K. K.

1 Kochan Z.

1 Krzyzaniak M.

1 Mlynarski W.

1 Nagel-Starczynowska G.

1 Piorkowski M.

1 Polakowska E.

1 Przygodzki T.

1 Rutkowski P.

1 Smolenski R.

1 Smolenski R. T.

1 Snieg M.

1 Stolarski M. J.

1 Swierczynski J.

1 Watala C.

1 Yacoub M. H.

1 Zych M.

1 2014

1 2011

1 2003

2 1999

Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line

Czy mutacja genu AMPD1, kodujacego izoenzym miesniowy deaminazy AMP u czlowieka, moze byc markerem prognostycznym pierwotnej kardiomiopatii rozstrzeniowej?

Decrease in daily urine excretion nad metabolites in patients with chronic renal failure

Thermophysical and chemical properties of perennial energy crops depending on harvest period

Differences in adenine incorporation between human and rat heart endothelium